Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016576524> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2016576524 abstract "Chenodeoxycholic acid (CDCA) was fed to pregnant rats at the 0.25% level in the diet from Day 11 of gestation to delivery in order to evaluate the effects on (1) maternal tissue bile acid composition, (2) neonatal tissue bile acid composition and cholesterol-7 alpha-hydroxylase activity, and (3) maternal, neonatal, and postnatal liver morphology. Feeding CDCA increased maternal lithocholic acid while significantly decreasing deoxycholic acid, cholic acid, and total bile acids. Feeding CDCA resulted in a significantly higher chenodeoxycholic acid pool in the neonates while neonatal plasma cholesterol and the 7 alpha-hydroxylation of cholesterol was not significantly affected. Morphological examination of maternal, neonatal, and postnatal rat liver revealed no significant hepatotoxicity. This investigation has shown that (a) neonates of CDCA fed dams have a significantly greater pool of CDCA, suggesting maternal-to-fetal transfer of dihydroxy bile acids, (b) neonatal cholesterol-7 alpha-hydroxylase activity and total tissue bile acid pools are not significantly altered by increased pool of CDCA, and (c) no hepatotoxic effects on maternal, neonatal, and postnatal livers were evident with gestational feeding of CDCA at the 0.25% level in the rat." @default.
- W2016576524 created "2016-06-24" @default.
- W2016576524 creator A5000303389 @default.
- W2016576524 creator A5039077029 @default.
- W2016576524 creator A5053389189 @default.
- W2016576524 date "1984-03-01" @default.
- W2016576524 modified "2023-10-16" @default.
- W2016576524 title "Effect of Chenodeoxycholic Acid Feeding during Gestation in the Rat on Bile Acid Metabolism and Liver Morphology" @default.
- W2016576524 doi "https://doi.org/10.3181/00379727-175-41811" @default.
- W2016576524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6694986" @default.
- W2016576524 hasPublicationYear "1984" @default.
- W2016576524 type Work @default.
- W2016576524 sameAs 2016576524 @default.
- W2016576524 citedByCount "4" @default.
- W2016576524 countsByYear W20165765242015 @default.
- W2016576524 crossrefType "journal-article" @default.
- W2016576524 hasAuthorship W2016576524A5000303389 @default.
- W2016576524 hasAuthorship W2016576524A5039077029 @default.
- W2016576524 hasAuthorship W2016576524A5053389189 @default.
- W2016576524 hasConcept C126322002 @default.
- W2016576524 hasConcept C134018914 @default.
- W2016576524 hasConcept C172680121 @default.
- W2016576524 hasConcept C2775900799 @default.
- W2016576524 hasConcept C2778163477 @default.
- W2016576524 hasConcept C2779234561 @default.
- W2016576524 hasConcept C2779399885 @default.
- W2016576524 hasConcept C2780420665 @default.
- W2016576524 hasConcept C2780749602 @default.
- W2016576524 hasConcept C2781089062 @default.
- W2016576524 hasConcept C46973012 @default.
- W2016576524 hasConcept C54355233 @default.
- W2016576524 hasConcept C71924100 @default.
- W2016576524 hasConcept C86803240 @default.
- W2016576524 hasConceptScore W2016576524C126322002 @default.
- W2016576524 hasConceptScore W2016576524C134018914 @default.
- W2016576524 hasConceptScore W2016576524C172680121 @default.
- W2016576524 hasConceptScore W2016576524C2775900799 @default.
- W2016576524 hasConceptScore W2016576524C2778163477 @default.
- W2016576524 hasConceptScore W2016576524C2779234561 @default.
- W2016576524 hasConceptScore W2016576524C2779399885 @default.
- W2016576524 hasConceptScore W2016576524C2780420665 @default.
- W2016576524 hasConceptScore W2016576524C2780749602 @default.
- W2016576524 hasConceptScore W2016576524C2781089062 @default.
- W2016576524 hasConceptScore W2016576524C46973012 @default.
- W2016576524 hasConceptScore W2016576524C54355233 @default.
- W2016576524 hasConceptScore W2016576524C71924100 @default.
- W2016576524 hasConceptScore W2016576524C86803240 @default.
- W2016576524 hasLocation W20165765241 @default.
- W2016576524 hasLocation W20165765242 @default.
- W2016576524 hasOpenAccess W2016576524 @default.
- W2016576524 hasPrimaryLocation W20165765241 @default.
- W2016576524 hasRelatedWork W1480791899 @default.
- W2016576524 hasRelatedWork W1989300953 @default.
- W2016576524 hasRelatedWork W2006917491 @default.
- W2016576524 hasRelatedWork W2028000484 @default.
- W2016576524 hasRelatedWork W2036280740 @default.
- W2016576524 hasRelatedWork W2077430695 @default.
- W2016576524 hasRelatedWork W2079283145 @default.
- W2016576524 hasRelatedWork W2137961868 @default.
- W2016576524 hasRelatedWork W2171700348 @default.
- W2016576524 hasRelatedWork W2399225705 @default.
- W2016576524 isParatext "false" @default.
- W2016576524 isRetracted "false" @default.
- W2016576524 magId "2016576524" @default.
- W2016576524 workType "article" @default.