FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016578593> ?p ?o ?g. }

• W2016578593 endingPage "42" @default.
• W2016578593 startingPage "38" @default.
• W2016578593 abstract "Although collagen pentapeptide (Lys-Thr-Thr-Lys-Ser, KTTKS) has received a great deal of attention owing to its collagen biosynthesis-stimulating effects, its enzymatic instability in the skin is an obstacle to effective topical application. PEGylation is a useful approach for improving the chemical and biological stability of peptides. However, the polydispersity of poly(ethylene glycol) (PEG) produces conjugates with different molecular sizes, which may create difficulties in chemical characterization and purity control, and in variability of biological properties. To overcome these difficulties, monodisperse PEG was site-specifically conjugated to the N-terminal amine of KTTKS to produce a single molecular conjugate, enabling more complete chemical characterization and more exact product specifications. PEG–KTTKS conjugates prepared using monodisperse PEG with two different molecular weights, monodisperse PEG220 and PEG572, were characterized by mass spectrometry. These monodisperse PEG–KTTKS conjugates showed no cytotoxicity (1–100 μM) and stimulated collagen biosynthesis in human skin fibroblasts. They also had high stability against proteolytic enzymes in rat skin. This study demonstrates the usefulness of monodisperse PEG for preparing chemically defined conjugates and suggests that monodisperse PEG-KTTKS would be a good candidate for use as a collagen biosynthesis-stimulating agent." @default.
• W2016578593 created "2016-06-24" @default.
• W2016578593 creator A5018293527 @default.
• W2016578593 creator A5062790247 @default.
• W2016578593 creator A5075284065 @default.
• W2016578593 date "2015-01-01" @default.
• W2016578593 modified "2023-09-24" @default.
• W2016578593 title "Synthesis and characterization of monodisperse poly(ethylene glycol)-conjugated collagen pentapeptides with collagen biosynthesis-stimulating activity" @default.
• W2016578593 cites W1484955349 @default.
• W2016578593 cites W1972761853 @default.
• W2016578593 cites W1988645530 @default.
• W2016578593 cites W1993603756 @default.
• W2016578593 cites W2006754098 @default.
• W2016578593 cites W2017203846 @default.
• W2016578593 cites W2019565591 @default.
• W2016578593 cites W2021725794 @default.
• W2016578593 cites W2029700985 @default.
• W2016578593 cites W2057927105 @default.
• W2016578593 cites W2065120981 @default.
• W2016578593 cites W2065876461 @default.
• W2016578593 cites W2069791068 @default.
• W2016578593 cites W2076113544 @default.
• W2016578593 cites W2077700497 @default.
• W2016578593 cites W2084587462 @default.
• W2016578593 cites W2095930245 @default.
• W2016578593 cites W2132295898 @default.
• W2016578593 cites W2137639632 @default.
• W2016578593 cites W2140156181 @default.
• W2016578593 cites W2329630442 @default.
• W2016578593 cites W2024860791 @default.
• W2016578593 doi "https://doi.org/10.1016/j.bmcl.2014.11.021" @default.
• W2016578593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25433999" @default.
• W2016578593 hasPublicationYear "2015" @default.
• W2016578593 type Work @default.
• W2016578593 sameAs 2016578593 @default.
• W2016578593 citedByCount "12" @default.
• W2016578593 countsByYear W20165785932016 @default.
• W2016578593 countsByYear W20165785932017 @default.
• W2016578593 countsByYear W20165785932018 @default.
• W2016578593 countsByYear W20165785932019 @default.
• W2016578593 countsByYear W20165785932021 @default.
• W2016578593 countsByYear W20165785932023 @default.
• W2016578593 crossrefType "journal-article" @default.
• W2016578593 hasAuthorship W2016578593A5018293527 @default.
• W2016578593 hasAuthorship W2016578593A5062790247 @default.
• W2016578593 hasAuthorship W2016578593A5075284065 @default.
• W2016578593 hasConcept C10138342 @default.
• W2016578593 hasConcept C112613896 @default.
• W2016578593 hasConcept C11432220 @default.
• W2016578593 hasConcept C134306372 @default.
• W2016578593 hasConcept C162324750 @default.
• W2016578593 hasConcept C178790620 @default.
• W2016578593 hasConcept C181199279 @default.
• W2016578593 hasConcept C185592680 @default.
• W2016578593 hasConcept C197336794 @default.
• W2016578593 hasConcept C21951064 @default.
• W2016578593 hasConcept C2776964284 @default.
• W2016578593 hasConcept C2777516009 @default.
• W2016578593 hasConcept C2779149719 @default.
• W2016578593 hasConcept C33923547 @default.
• W2016578593 hasConcept C521977710 @default.
• W2016578593 hasConcept C54400483 @default.
• W2016578593 hasConcept C553450214 @default.
• W2016578593 hasConcept C55493867 @default.
• W2016578593 hasConceptScore W2016578593C10138342 @default.
• W2016578593 hasConceptScore W2016578593C112613896 @default.
• W2016578593 hasConceptScore W2016578593C11432220 @default.
• W2016578593 hasConceptScore W2016578593C134306372 @default.
• W2016578593 hasConceptScore W2016578593C162324750 @default.
• W2016578593 hasConceptScore W2016578593C178790620 @default.
• W2016578593 hasConceptScore W2016578593C181199279 @default.
• W2016578593 hasConceptScore W2016578593C185592680 @default.
• W2016578593 hasConceptScore W2016578593C197336794 @default.
• W2016578593 hasConceptScore W2016578593C21951064 @default.
• W2016578593 hasConceptScore W2016578593C2776964284 @default.
• W2016578593 hasConceptScore W2016578593C2777516009 @default.
• W2016578593 hasConceptScore W2016578593C2779149719 @default.
• W2016578593 hasConceptScore W2016578593C33923547 @default.
• W2016578593 hasConceptScore W2016578593C521977710 @default.
• W2016578593 hasConceptScore W2016578593C54400483 @default.
• W2016578593 hasConceptScore W2016578593C553450214 @default.
• W2016578593 hasConceptScore W2016578593C55493867 @default.
• W2016578593 hasFunder F4320322120 @default.
• W2016578593 hasIssue "1" @default.
• W2016578593 hasLocation W20165785931 @default.
• W2016578593 hasLocation W20165785932 @default.
• W2016578593 hasOpenAccess W2016578593 @default.
• W2016578593 hasPrimaryLocation W20165785931 @default.
• W2016578593 hasRelatedWork W1595946216 @default.
• W2016578593 hasRelatedWork W1994112378 @default.
• W2016578593 hasRelatedWork W1996860722 @default.
• W2016578593 hasRelatedWork W2016578593 @default.
• W2016578593 hasRelatedWork W2033354509 @default.
• W2016578593 hasRelatedWork W2318646981 @default.
• W2016578593 hasRelatedWork W2791571775 @default.
• W2016578593 hasRelatedWork W2793674301 @default.
• W2016578593 hasRelatedWork W3092464250 @default.
• W2016578593 hasRelatedWork W4386208867 @default.

• next