Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016581978> ?p ?o ?g. }
- W2016581978 endingPage "11" @default.
- W2016581978 startingPage "1" @default.
- W2016581978 abstract "Mitochondria are highly dynamic, complex organelles that continuously alter their shape, ranging between two opposite processes, fission and fusion, in response to several stimuli and the metabolic demands of the cell. Alterations in mitochondrial dynamics due to mutations in proteins involved in the fusion-fission machinery represent an important pathogenic mechanism of human diseases. The most relevant proteins involved in the mitochondrial fusion process are three GTPase dynamin-like proteins: mitofusin 1 (MFN1) and 2 (MFN2), located in the outer mitochondrial membrane, and optic atrophy protein 1 (OPA1), in the inner membrane. An expanding number of degenerative disorders are associated with mutations in the genes encoding MFN2 and OPA1, including Charcot-Marie-Tooth disease type 2A and autosomal dominant optic atrophy. While these disorders can still be considered rare, defective mitochondrial dynamics seem to play a significant role in the molecular and cellular pathogenesis of more common neurodegenerative diseases, for example, Alzheimer’s and Parkinson’s diseases. This review provides an overview of the basic molecular mechanisms involved in mitochondrial fusion and focuses on the alteration in mitochondrial DNA amount resulting from impairment of mitochondrial dynamics. We also review the literature describing the main disorders associated with the disruption of mitochondrial fusion." @default.
- W2016581978 created "2016-06-24" @default.
- W2016581978 creator A5025891628 @default.
- W2016581978 creator A5031953083 @default.
- W2016581978 creator A5037844377 @default.
- W2016581978 creator A5054718225 @default.
- W2016581978 creator A5060263136 @default.
- W2016581978 creator A5076321492 @default.
- W2016581978 creator A5080427278 @default.
- W2016581978 creator A5082719787 @default.
- W2016581978 date "2013-01-01" @default.
- W2016581978 modified "2023-10-11" @default.
- W2016581978 title "Mitochondrial Fusion Proteins and Human Diseases" @default.
- W2016581978 cites W1493752155 @default.
- W2016581978 cites W1519184577 @default.
- W2016581978 cites W1561484646 @default.
- W2016581978 cites W1608592225 @default.
- W2016581978 cites W1877873625 @default.
- W2016581978 cites W1963715201 @default.
- W2016581978 cites W1964307377 @default.
- W2016581978 cites W1967445833 @default.
- W2016581978 cites W1970565325 @default.
- W2016581978 cites W1972476228 @default.
- W2016581978 cites W1973047169 @default.
- W2016581978 cites W1973137057 @default.
- W2016581978 cites W1975562298 @default.
- W2016581978 cites W1979264179 @default.
- W2016581978 cites W1980617309 @default.
- W2016581978 cites W1985449116 @default.
- W2016581978 cites W1986325345 @default.
- W2016581978 cites W1986996580 @default.
- W2016581978 cites W1987845572 @default.
- W2016581978 cites W1989026904 @default.
- W2016581978 cites W1989111482 @default.
- W2016581978 cites W1989540421 @default.
- W2016581978 cites W2000130811 @default.
- W2016581978 cites W2005271645 @default.
- W2016581978 cites W2005607645 @default.
- W2016581978 cites W2007001213 @default.
- W2016581978 cites W2016671984 @default.
- W2016581978 cites W2018429076 @default.
- W2016581978 cites W2020352306 @default.
- W2016581978 cites W2022279971 @default.
- W2016581978 cites W2022524737 @default.
- W2016581978 cites W2022827866 @default.
- W2016581978 cites W2025405718 @default.
- W2016581978 cites W2026428819 @default.
- W2016581978 cites W2028762215 @default.
- W2016581978 cites W2031280902 @default.
- W2016581978 cites W2031603359 @default.
- W2016581978 cites W2037056102 @default.
- W2016581978 cites W2037089513 @default.
- W2016581978 cites W2038976751 @default.
- W2016581978 cites W2045726869 @default.
- W2016581978 cites W2047530983 @default.
- W2016581978 cites W2053244885 @default.
- W2016581978 cites W2059644202 @default.
- W2016581978 cites W2060811345 @default.
- W2016581978 cites W2065124025 @default.
- W2016581978 cites W2066913030 @default.
- W2016581978 cites W2071337010 @default.
- W2016581978 cites W2072173203 @default.
- W2016581978 cites W2078823038 @default.
- W2016581978 cites W2089141103 @default.
- W2016581978 cites W2090168827 @default.
- W2016581978 cites W2091540470 @default.
- W2016581978 cites W2091701724 @default.
- W2016581978 cites W2093662055 @default.
- W2016581978 cites W2097704104 @default.
- W2016581978 cites W2102445981 @default.
- W2016581978 cites W2102626915 @default.
- W2016581978 cites W2103309568 @default.
- W2016581978 cites W2104412320 @default.
- W2016581978 cites W2107030671 @default.
- W2016581978 cites W2109942343 @default.
- W2016581978 cites W2114042564 @default.
- W2016581978 cites W2114238634 @default.
- W2016581978 cites W2115995998 @default.
- W2016581978 cites W2116023338 @default.
- W2016581978 cites W2118606437 @default.
- W2016581978 cites W2120001424 @default.
- W2016581978 cites W2120695551 @default.
- W2016581978 cites W2123779991 @default.
- W2016581978 cites W2126624770 @default.
- W2016581978 cites W2126932378 @default.
- W2016581978 cites W2127271204 @default.
- W2016581978 cites W2127806759 @default.
- W2016581978 cites W2129740452 @default.
- W2016581978 cites W2130733383 @default.
- W2016581978 cites W2135683358 @default.
- W2016581978 cites W2137394274 @default.
- W2016581978 cites W2146861549 @default.
- W2016581978 cites W2147207574 @default.
- W2016581978 cites W2148471604 @default.
- W2016581978 cites W2149108521 @default.
- W2016581978 cites W2151698573 @default.
- W2016581978 cites W2152674951 @default.
- W2016581978 cites W2153275586 @default.