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• W2016589481 startingPage "1290" @default.
• W2016589481 abstract "Reactive oxygen species, such as hydrogen peroxide (H 2 O 2 ), exert a critical regulatory role on skeletal muscle function. Whether acute increases in H 2 O 2 modulate muscle microvascular O 2 delivery-utilization (Q̇o 2 /V̇o 2 ) matching [i.e., microvascular partial pressure of O 2 (Pmv O 2 )] at rest and following the onset of contractions is unknown. The hypothesis was tested that H 2 O 2 treatment (exogenous H 2 O 2 ) would enhance Pmv O 2 and slow Pmv O 2 kinetics during contractions compared with control. Anesthetized, healthy young Sprague-Dawley rats had their spinotrapezius muscles either exposed for measurement of blood flow (and therefore Q̇o 2 ), V̇o 2 , and Pmv O 2 , or exteriorized for measurement of force production. Electrically stimulated twitch contractions (1 Hz, ∼7 V, 2-ms pulse duration, 3 min) were evoked following acute superfusion with Krebs-Henseleit (control) and H 2 O 2 (100 μM). Relative to control, H 2 O 2 treatment elicited disproportionate increases in Q̇o 2 and V̇o 2 that elevated Pmv O 2 at rest and throughout contractions and slowed overall Pmv O 2 kinetics (i.e., ∼85% slower mean response time; P < 0.05). Accordingly, H 2 O 2 resulted in ∼33% greater overall Pmv O 2 , as assessed by the area under the Pmv O 2 curve ( P < 0.05). Muscle force production was not altered with H 2 O 2 treatment ( P > 0.05), evidencing reduced economy during contractions (∼40% decrease in the force/V̇o 2 relationship; P < 0.05). These findings indicate that, although increasing the driving force for blood-myocyte O 2 flux (i.e., Pmv O 2 ), transient elevations in H 2 O 2 impair skeletal muscle function (i.e., reduced economy during contractions), which mechanistically may underlie, in part, the reduced exercise tolerance in conditions associated with oxidative stress." @default.
• W2016589481 created "2016-06-24" @default.
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• W2016589481 date "2011-05-01" @default.
• W2016589481 modified "2023-09-28" @default.
• W2016589481 title "Acute effects of hydrogen peroxide on skeletal muscle microvascular oxygenation from rest to contractions" @default.
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• W2016589481 doi "https://doi.org/10.1152/japplphysiol.01489.2010" @default.
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• W2016589481 hasPublicationYear "2011" @default.
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