FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016594669> ?p ?o ?g. }

• W2016594669 abstract "Intestinal transport is disturbed in cystic fibrosis (CF), with both defective Cl- secretion and changes in absorption being reported. We have examined the effects of the disease on Na(+)-dependent glucose absorption by the small intestine. Active glucose absorption was monitored as changes in short-circuit current (SCC) in intact and stripped intestinal sheets from normal (Swiss) and transgenic CF (Cftr(tm1Eur) and Cftr(tm2Cam)) mice with the DeltaF508 mutation, and in jejunal biopsies from children with CF and normal controls. Na(+)-dependent glucose uptake at the luminal membrane was measured in brush-border membrane vesicles (BBMVs). Intact and stripped sheets of jejunum and midintestine from Swiss mice exhibited a concentration-dependent increase in SCC with glucose. Apparent Km values were similar in the two preparations, but the apparent Vmax was greater in stripped sheets. This difference was not due to a loss of neural activity in stripped sheets as tetrodotoxin did not influence the glucose-induced SCC in intact sheets. Similar results were observed in stripped sheets of jejunum and mid-intestine from wild-type Cftr(tm1Eur) mice, but in tissues from CF mice the apparent Vmax value was reduced significantly. A lower Vmax was also obtained in intact sheets of mid-intestine from CF (Cftr(tm2Cam)) mice. Jejunal biopsies from CF patients however, exhibited an enhanced glucose-dependent rise in SCC. Na(+)-dependent uptake by BBMVs from CF (Cftr(tm1Eur)) mice was not reduced compared with wild-type and Swiss BBMVs. It was concluded that, in contrast to human intestine, intestinal glucose absorption was reduced in transgenic mouse models of CF with the DeltaF508 mutation, but that this could not be detected in an isolated preparation of brush-border membranes. Transgenic mouse models of CF may not accurately reflect all aspects of intestinal dysfunction in the human disease." @default.
• W2016594669 created "2016-06-24" @default.
• W2016594669 creator A5005916985 @default.
• W2016594669 creator A5060052713 @default.
• W2016594669 creator A5075140869 @default.
• W2016594669 date "2004-03-01" @default.
• W2016594669 modified "2023-10-17" @default.
• W2016594669 title "Small intestinal glucose absorption in cystic fibrosis: a study in human and transgenic ΔF508 cystic fibrosis mouse tissues" @default.
• W2016594669 cites W1482359363 @default.
• W2016594669 cites W1503660683 @default.
• W2016594669 cites W1573745866 @default.
• W2016594669 cites W1756665877 @default.
• W2016594669 cites W1956777900 @default.
• W2016594669 cites W1965180344 @default.
• W2016594669 cites W1965503486 @default.
• W2016594669 cites W1968004283 @default.
• W2016594669 cites W1977174915 @default.
• W2016594669 cites W1977188111 @default.
• W2016594669 cites W1988101098 @default.
• W2016594669 cites W1991467921 @default.
• W2016594669 cites W1993023653 @default.
• W2016594669 cites W2005247519 @default.
• W2016594669 cites W2008780101 @default.
• W2016594669 cites W2009028304 @default.
• W2016594669 cites W2009695810 @default.
• W2016594669 cites W2045844574 @default.
• W2016594669 cites W2049593516 @default.
• W2016594669 cites W2053910830 @default.
• W2016594669 cites W2064555996 @default.
• W2016594669 cites W2067923439 @default.
• W2016594669 cites W2069547775 @default.
• W2016594669 cites W2137012287 @default.
• W2016594669 cites W2151904980 @default.
• W2016594669 cites W2170265384 @default.
• W2016594669 cites W2170372540 @default.
• W2016594669 cites W2173634416 @default.
• W2016594669 cites W264597262 @default.
• W2016594669 doi "https://doi.org/10.1211/0022357022863" @default.
• W2016594669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15025858" @default.
• W2016594669 hasPublicationYear "2004" @default.
• W2016594669 type Work @default.
• W2016594669 sameAs 2016594669 @default.
• W2016594669 citedByCount "7" @default.
• W2016594669 countsByYear W20165946692013 @default.
• W2016594669 countsByYear W20165946692015 @default.
• W2016594669 countsByYear W20165946692016 @default.
• W2016594669 crossrefType "journal-article" @default.
• W2016594669 hasAuthorship W2016594669A5005916985 @default.
• W2016594669 hasAuthorship W2016594669A5060052713 @default.
• W2016594669 hasAuthorship W2016594669A5075140869 @default.
• W2016594669 hasBestOaLocation W20165946691 @default.
• W2016594669 hasConcept C102230213 @default.
• W2016594669 hasConcept C104317684 @default.
• W2016594669 hasConcept C121332964 @default.
• W2016594669 hasConcept C125287762 @default.
• W2016594669 hasConcept C126322002 @default.
• W2016594669 hasConcept C130316041 @default.
• W2016594669 hasConcept C134018914 @default.
• W2016594669 hasConcept C141035611 @default.
• W2016594669 hasConcept C185592680 @default.
• W2016594669 hasConcept C24890656 @default.
• W2016594669 hasConcept C2776366702 @default.
• W2016594669 hasConcept C2776938444 @default.
• W2016594669 hasConcept C2777226302 @default.
• W2016594669 hasConcept C2777882243 @default.
• W2016594669 hasConcept C2777893369 @default.
• W2016594669 hasConcept C2778428886 @default.
• W2016594669 hasConcept C41625074 @default.
• W2016594669 hasConcept C49039625 @default.
• W2016594669 hasConcept C5426402 @default.
• W2016594669 hasConcept C55493867 @default.
• W2016594669 hasConcept C71924100 @default.
• W2016594669 hasConcept C86803240 @default.
• W2016594669 hasConceptScore W2016594669C102230213 @default.
• W2016594669 hasConceptScore W2016594669C104317684 @default.
• W2016594669 hasConceptScore W2016594669C121332964 @default.
• W2016594669 hasConceptScore W2016594669C125287762 @default.
• W2016594669 hasConceptScore W2016594669C126322002 @default.
• W2016594669 hasConceptScore W2016594669C130316041 @default.
• W2016594669 hasConceptScore W2016594669C134018914 @default.
• W2016594669 hasConceptScore W2016594669C141035611 @default.
• W2016594669 hasConceptScore W2016594669C185592680 @default.
• W2016594669 hasConceptScore W2016594669C24890656 @default.
• W2016594669 hasConceptScore W2016594669C2776366702 @default.
• W2016594669 hasConceptScore W2016594669C2776938444 @default.
• W2016594669 hasConceptScore W2016594669C2777226302 @default.
• W2016594669 hasConceptScore W2016594669C2777882243 @default.
• W2016594669 hasConceptScore W2016594669C2777893369 @default.
• W2016594669 hasConceptScore W2016594669C2778428886 @default.
• W2016594669 hasConceptScore W2016594669C41625074 @default.
• W2016594669 hasConceptScore W2016594669C49039625 @default.
• W2016594669 hasConceptScore W2016594669C5426402 @default.
• W2016594669 hasConceptScore W2016594669C55493867 @default.
• W2016594669 hasConceptScore W2016594669C71924100 @default.
• W2016594669 hasConceptScore W2016594669C86803240 @default.
• W2016594669 hasLocation W20165946691 @default.
• W2016594669 hasLocation W20165946692 @default.
• W2016594669 hasOpenAccess W2016594669 @default.
• W2016594669 hasPrimaryLocation W20165946691 @default.
• W2016594669 hasRelatedWork W143166540 @default.

• next