FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016596327> ?p ?o ?g. }

• W2016596327 endingPage "214" @default.
• W2016596327 startingPage "214" @default.
• W2016596327 abstract "Toxin complex (Tc) proteins termed TcaABC, TcdAB, and TccABC with insecticidal activity are present in a variety of bacteria including the yersiniae.The tc gene sequences of thirteen Yersinia strains were compared, revealing a high degree of gene order conservation, but also remarkable differences with respect to pseudogenes, sequence variability and gene duplications. Outside the tc pathogenicity island (tc-PAIYe) of Y. enterocolitica strain W22703, a pseudogene (tccC2'/3') encoding proteins with homology to TccC and similarity to tyrosine phosphatases at its C-terminus was identified. PCR analysis revealed the presence of the tc-PAIYe and of tccC2'/3'-homologues in all biotype 2-5 strains tested, and their absence in most representatives of biotypes 1A and 1B. Phylogenetic analysis of 39 TccC sequences indicates the presence of the tc-PAIYe in an ancestor of Yersinia. Oral uptake experiments with Manduca sexta revealed a higher larvae lethality of Yersinia strains harbouring the tc-PAIYe in comparison to strains lacking this island. Following subcutaneous infection of Galleria mellonella larvae with five non-human pathogenic Yersinia spp. and four Y. enterocolitica strains, we observed a remarkable variability of their insecticidal activity ranging from 20% (Y. kristensenii) to 90% (Y. enterocolitica strain 2594) dead larvae after five days. Strain W22703 and its tcaA deletion mutant did not exhibit a significantly different toxicity towards G. mellonella. These data confirm a role of TcaA upon oral uptake only, and suggest the presence of further insecticidal determinants in Yersinia strains formerly unknown to kill insects.This study investigated the tc gene distribution among yersiniae and the phylogenetic relationship between TccC proteins, thus contributing novel aspects to the current discussion about the evolution of insecticidal toxins in the genus Yersinia. The toxic potential of several Yersinia spp. towards M. sexta and G. mellonella demonstrated here for the first time points to insects as a natural reservoir for yersiniae." @default.
• W2016596327 created "2016-06-24" @default.
• W2016596327 creator A5046665812 @default.
• W2016596327 creator A5050827885 @default.
• W2016596327 creator A5052844897 @default.
• W2016596327 creator A5063596187 @default.
• W2016596327 creator A5088597040 @default.
• W2016596327 date "2008-01-01" @default.
• W2016596327 modified "2023-09-25" @default.
• W2016596327 title "Insecticidal genes of Yersinia spp.: taxonomical distribution, contribution to toxicity towards Manduca sexta and Galleria mellonella, and evolution" @default.
• W2016596327 cites W1495911638 @default.
• W2016596327 cites W1572691776 @default.
• W2016596327 cites W1720086237 @default.
• W2016596327 cites W1863849442 @default.
• W2016596327 cites W1891373483 @default.
• W2016596327 cites W1965102600 @default.
• W2016596327 cites W1966493554 @default.
• W2016596327 cites W1973482210 @default.
• W2016596327 cites W1993385448 @default.
• W2016596327 cites W1998712064 @default.
• W2016596327 cites W2013120122 @default.
• W2016596327 cites W2023091213 @default.
• W2016596327 cites W2038105373 @default.
• W2016596327 cites W2053808754 @default.
• W2016596327 cites W2056274611 @default.
• W2016596327 cites W2065461553 @default.
• W2016596327 cites W2068823727 @default.
• W2016596327 cites W2080380824 @default.
• W2016596327 cites W2086905640 @default.
• W2016596327 cites W2106882534 @default.
• W2016596327 cites W2112952835 @default.
• W2016596327 cites W2128625079 @default.
• W2016596327 cites W2143760169 @default.
• W2016596327 cites W2155329697 @default.
• W2016596327 cites W2158334329 @default.
• W2016596327 cites W2162932360 @default.
• W2016596327 cites W2164687473 @default.
• W2016596327 cites W2169879234 @default.
• W2016596327 cites W2170720827 @default.
• W2016596327 cites W2407317643 @default.
• W2016596327 cites W2804007336 @default.
• W2016596327 doi "https://doi.org/10.1186/1471-2180-8-214" @default.
• W2016596327 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2613401" @default.
• W2016596327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19063735" @default.
• W2016596327 hasPublicationYear "2008" @default.
• W2016596327 type Work @default.
• W2016596327 sameAs 2016596327 @default.
• W2016596327 citedByCount "55" @default.
• W2016596327 countsByYear W20165963272012 @default.
• W2016596327 countsByYear W20165963272013 @default.
• W2016596327 countsByYear W20165963272014 @default.
• W2016596327 countsByYear W20165963272015 @default.
• W2016596327 countsByYear W20165963272016 @default.
• W2016596327 countsByYear W20165963272017 @default.
• W2016596327 countsByYear W20165963272018 @default.
• W2016596327 countsByYear W20165963272019 @default.
• W2016596327 countsByYear W20165963272020 @default.
• W2016596327 countsByYear W20165963272021 @default.
• W2016596327 countsByYear W20165963272022 @default.
• W2016596327 countsByYear W20165963272023 @default.
• W2016596327 crossrefType "journal-article" @default.
• W2016596327 hasAuthorship W2016596327A5046665812 @default.
• W2016596327 hasAuthorship W2016596327A5050827885 @default.
• W2016596327 hasAuthorship W2016596327A5052844897 @default.
• W2016596327 hasAuthorship W2016596327A5063596187 @default.
• W2016596327 hasAuthorship W2016596327A5088597040 @default.
• W2016596327 hasBestOaLocation W20165963271 @default.
• W2016596327 hasConcept C104317684 @default.
• W2016596327 hasConcept C141231307 @default.
• W2016596327 hasConcept C165525559 @default.
• W2016596327 hasConcept C173758957 @default.
• W2016596327 hasConcept C2776234502 @default.
• W2016596327 hasConcept C2776255393 @default.
• W2016596327 hasConcept C2779032433 @default.
• W2016596327 hasConcept C2780312687 @default.
• W2016596327 hasConcept C34957205 @default.
• W2016596327 hasConcept C523546767 @default.
• W2016596327 hasConcept C54355233 @default.
• W2016596327 hasConcept C59822182 @default.
• W2016596327 hasConcept C60987743 @default.
• W2016596327 hasConcept C86803240 @default.
• W2016596327 hasConcept C89423630 @default.
• W2016596327 hasConceptScore W2016596327C104317684 @default.
• W2016596327 hasConceptScore W2016596327C141231307 @default.
• W2016596327 hasConceptScore W2016596327C165525559 @default.
• W2016596327 hasConceptScore W2016596327C173758957 @default.
• W2016596327 hasConceptScore W2016596327C2776234502 @default.
• W2016596327 hasConceptScore W2016596327C2776255393 @default.
• W2016596327 hasConceptScore W2016596327C2779032433 @default.
• W2016596327 hasConceptScore W2016596327C2780312687 @default.
• W2016596327 hasConceptScore W2016596327C34957205 @default.
• W2016596327 hasConceptScore W2016596327C523546767 @default.
• W2016596327 hasConceptScore W2016596327C54355233 @default.
• W2016596327 hasConceptScore W2016596327C59822182 @default.
• W2016596327 hasConceptScore W2016596327C60987743 @default.
• W2016596327 hasConceptScore W2016596327C86803240 @default.
• W2016596327 hasConceptScore W2016596327C89423630 @default.
• W2016596327 hasIssue "1" @default.

• next