FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016597337> ?p ?o ?g. }

• W2016597337 endingPage "1129" @default.
• W2016597337 startingPage "1124" @default.
• W2016597337 abstract "Background and Purpose Oxygen free radicals or oxidants have been proposed to be involved in acute central nervous system injury that is produced by cerebral ischemia and reperfusion. Because of the transient nature of oxygen radicals and the technical difficulties inherent in accurately measuring their levels in the brain, experimental strategies have been focused on the use of pharmacological agents and antioxidants to seek a correlation between the exogenously supplied specific radical scavengers (ie, superoxide dismutase and catalase) and the subsequent protection of cerebral tissues from ischemic injury. However, this strategy entails problems (hemodynamic, pharmacokinetic, toxicity, blood-brain barrier permeability, etc) that may cloud the data interpretation. This mini-review will focus on the oxidant mechanisms in cerebral ischemic brain injury by using transgenic and knockout mice as an alternative approach. Methods Transgenic and knockout mutants that either overexpress or are deficient in antioxidant enzyme/protein levels have been successfully produced. The availability of these genetically modified animals has made it possible to investigate the role of certain oxidants in ischemic brain cell damage in molecular fashion. Results It has been shown that an increased level of CuZn–superoxide dismutase and antiapoptotic protein Bcl-2 in the brains of transgenic mice protects neurons from ischemic/reperfusion injury, whereas a deficiency in CuZn–superoxide dismutase or mitochondrial Mn–superoxide dismutase exacerbates ischemic brain damage. Target disruption of neuronal nitric oxide synthase in mice also provides neuronal protection against permanent and transient focal cerebral ischemia. Conclusions I conclude that molecular genetic approaches in modifying antioxidant levels in the brain offer a unique tool for understanding the role of oxidants in ischemic brain damage." @default.
• W2016597337 created "2016-06-24" @default.
• W2016597337 creator A5073936292 @default.
• W2016597337 date "1996-06-01" @default.
• W2016597337 modified "2023-10-14" @default.
• W2016597337 title "Role of Oxidants in Ischemic Brain Damage" @default.
• W2016597337 cites W1549546756 @default.
• W2016597337 cites W1606988289 @default.
• W2016597337 cites W1920883260 @default.
• W2016597337 cites W1925799544 @default.
• W2016597337 cites W1968283357 @default.
• W2016597337 cites W1970928392 @default.
• W2016597337 cites W1976541392 @default.
• W2016597337 cites W1978348298 @default.
• W2016597337 cites W1985683891 @default.
• W2016597337 cites W1988951836 @default.
• W2016597337 cites W1989391366 @default.
• W2016597337 cites W1993834457 @default.
• W2016597337 cites W2002526073 @default.
• W2016597337 cites W2017074139 @default.
• W2016597337 cites W2017199287 @default.
• W2016597337 cites W2020569812 @default.
• W2016597337 cites W2020914812 @default.
• W2016597337 cites W2029947381 @default.
• W2016597337 cites W2033828028 @default.
• W2016597337 cites W2037473273 @default.
• W2016597337 cites W2038978204 @default.
• W2016597337 cites W2040053768 @default.
• W2016597337 cites W2043561221 @default.
• W2016597337 cites W2047254990 @default.
• W2016597337 cites W2053640261 @default.
• W2016597337 cites W2058137293 @default.
• W2016597337 cites W2061562492 @default.
• W2016597337 cites W2062384458 @default.
• W2016597337 cites W2065264404 @default.
• W2016597337 cites W2067072091 @default.
• W2016597337 cites W2074187719 @default.
• W2016597337 cites W2083560313 @default.
• W2016597337 cites W2085935168 @default.
• W2016597337 cites W2091193879 @default.
• W2016597337 cites W2094655287 @default.
• W2016597337 cites W2109893157 @default.
• W2016597337 cites W2114282533 @default.
• W2016597337 cites W2122515902 @default.
• W2016597337 cites W2133739669 @default.
• W2016597337 cites W2139323441 @default.
• W2016597337 cites W2155747798 @default.
• W2016597337 cites W2169122437 @default.
• W2016597337 cites W944209541 @default.
• W2016597337 doi "https://doi.org/10.1161/01.str.27.6.1124" @default.
• W2016597337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8650725" @default.
• W2016597337 hasPublicationYear "1996" @default.
• W2016597337 type Work @default.
• W2016597337 sameAs 2016597337 @default.
• W2016597337 citedByCount "942" @default.
• W2016597337 countsByYear W20165973372012 @default.
• W2016597337 countsByYear W20165973372013 @default.
• W2016597337 countsByYear W20165973372014 @default.
• W2016597337 countsByYear W20165973372015 @default.
• W2016597337 countsByYear W20165973372016 @default.
• W2016597337 countsByYear W20165973372017 @default.
• W2016597337 countsByYear W20165973372018 @default.
• W2016597337 countsByYear W20165973372019 @default.
• W2016597337 countsByYear W20165973372020 @default.
• W2016597337 countsByYear W20165973372021 @default.
• W2016597337 countsByYear W20165973372022 @default.
• W2016597337 countsByYear W20165973372023 @default.
• W2016597337 crossrefType "journal-article" @default.
• W2016597337 hasAuthorship W2016597337A5073936292 @default.
• W2016597337 hasConcept C102230213 @default.
• W2016597337 hasConcept C104317684 @default.
• W2016597337 hasConcept C126322002 @default.
• W2016597337 hasConcept C141035611 @default.
• W2016597337 hasConcept C181199279 @default.
• W2016597337 hasConcept C2775838275 @default.
• W2016597337 hasConcept C2776151105 @default.
• W2016597337 hasConcept C2777622882 @default.
• W2016597337 hasConcept C2778004101 @default.
• W2016597337 hasConcept C2778402981 @default.
• W2016597337 hasConcept C2778820722 @default.
• W2016597337 hasConcept C2778979269 @default.
• W2016597337 hasConcept C2780114680 @default.
• W2016597337 hasConcept C2780795997 @default.
• W2016597337 hasConcept C2781458332 @default.
• W2016597337 hasConcept C48349386 @default.
• W2016597337 hasConcept C519581460 @default.
• W2016597337 hasConcept C529278444 @default.
• W2016597337 hasConcept C541997718 @default.
• W2016597337 hasConcept C55493867 @default.
• W2016597337 hasConcept C71924100 @default.
• W2016597337 hasConcept C86803240 @default.
• W2016597337 hasConcept C98274493 @default.
• W2016597337 hasConceptScore W2016597337C102230213 @default.
• W2016597337 hasConceptScore W2016597337C104317684 @default.
• W2016597337 hasConceptScore W2016597337C126322002 @default.
• W2016597337 hasConceptScore W2016597337C141035611 @default.
• W2016597337 hasConceptScore W2016597337C181199279 @default.
• W2016597337 hasConceptScore W2016597337C2775838275 @default.

• next