FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016598746> ?p ?o ?g. }

• W2016598746 endingPage "405" @default.
• W2016598746 startingPage "395" @default.
• W2016598746 abstract "The thermoregulatory responses to dopamine (DA), noradrenaline (NA) and 5-hydroxytryptamine (5-HT), injected into the third cerebral ventricle of goats at 20°C ambient temperature (Ta) or during cold exposure, were compared before and after pretreatment with the DA receptor blocker haloperidol or the 5-HT receptor blocker methysergide. At 20°C Ta, intracerebroventricular (i.c.v.) injection of DA (800 μg), NA (200 μg) or 5-HT (800 μg) induced a decrease in body temperature (Tb) and dilatation of the ear vessels. After DA and 5-HT, but not after NA, panting was observed. During cold exposure both DA and NA caused a suppression of shivering and a fall in Tb. Pretreatment with haloperidol (400 μg, i.c.v.) attenuated the thermoregulatory effects of i.c.v. DA other than the dilatation of the ear vessels at 20°C Ta. Haloperidol did not influence the responses after i.c.v. NA or 5-HT. Methysergide (1.0 mg, i.c.v.) blocked panting and attenuated the decrease in Tb caused by i.c.v. DA and 5-HT at 20°C Ta and blocked the peripheral vasodilatation caused by 5-HT but not the dilatation caused by DA. During cold exposure methysergide antagonized the thermoregulatory effects of DA, but not those of NA. I.c.v. injection of haloperidol (400 μg) or methysergide (1.0 mg) during heat exposure induced a decrease in panting and a rise in body temperature, which suggests that both DA and 5-HT have a physiological role in the mediation of heat loss in the goat. We conclude that in the central thermoregulatory system of the goat there are excitatory DA receptors in the pathway from heat sensors to heat loss effectors. Activation of these receptors by i.c.v. DA or by heat exposure results in a secondary release of 5-HT. Since the vasodilating effect of DA was not influenced by haloperidol or methysergide, this effect could be mediated by haloperidol-insensitive (possibly inhibitory) DA receptors on the pathway controlling peripheral vasomotor tone. The thermoregulatory effects of i.c.v. NA are probably mediated by inhibitory NA receptors on the pathway from cold sensors to heat production effectors." @default.
• W2016598746 created "2016-06-24" @default.
• W2016598746 creator A5056677670 @default.
• W2016598746 creator A5069459771 @default.
• W2016598746 creator A5080881224 @default.
• W2016598746 creator A5088100844 @default.
• W2016598746 date "1978-06-01" @default.
• W2016598746 modified "2023-09-27" @default.
• W2016598746 title "Comparison of the thermoregulatory responses to intracerebroventricularly injected dopamine, noradrenaline and 5-hydroxytryptamine in the goat" @default.
• W2016598746 cites W1968485866 @default.
• W2016598746 cites W1977347101 @default.
• W2016598746 cites W1979119611 @default.
• W2016598746 cites W1989702866 @default.
• W2016598746 cites W1993160794 @default.
• W2016598746 cites W2012187592 @default.
• W2016598746 cites W2013718093 @default.
• W2016598746 cites W2024381199 @default.
• W2016598746 cites W2057575309 @default.
• W2016598746 cites W2063608291 @default.
• W2016598746 cites W2077839327 @default.
• W2016598746 cites W2120123696 @default.
• W2016598746 cites W2141542195 @default.
• W2016598746 doi "https://doi.org/10.1016/0014-2999(78)90314-x" @default.
• W2016598746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/668811" @default.
• W2016598746 hasPublicationYear "1978" @default.
• W2016598746 type Work @default.
• W2016598746 sameAs 2016598746 @default.
• W2016598746 citedByCount "14" @default.
• W2016598746 crossrefType "journal-article" @default.
• W2016598746 hasAuthorship W2016598746A5056677670 @default.
• W2016598746 hasAuthorship W2016598746A5069459771 @default.
• W2016598746 hasAuthorship W2016598746A5080881224 @default.
• W2016598746 hasAuthorship W2016598746A5088100844 @default.
• W2016598746 hasConcept C100564792 @default.
• W2016598746 hasConcept C126322002 @default.
• W2016598746 hasConcept C134018914 @default.
• W2016598746 hasConcept C170493617 @default.
• W2016598746 hasConcept C185592680 @default.
• W2016598746 hasConcept C2775864247 @default.
• W2016598746 hasConcept C2780948584 @default.
• W2016598746 hasConcept C2781005078 @default.
• W2016598746 hasConcept C2781258859 @default.
• W2016598746 hasConcept C42219234 @default.
• W2016598746 hasConcept C513476851 @default.
• W2016598746 hasConcept C53910766 @default.
• W2016598746 hasConcept C71924100 @default.
• W2016598746 hasConceptScore W2016598746C100564792 @default.
• W2016598746 hasConceptScore W2016598746C126322002 @default.
• W2016598746 hasConceptScore W2016598746C134018914 @default.
• W2016598746 hasConceptScore W2016598746C170493617 @default.
• W2016598746 hasConceptScore W2016598746C185592680 @default.
• W2016598746 hasConceptScore W2016598746C2775864247 @default.
• W2016598746 hasConceptScore W2016598746C2780948584 @default.
• W2016598746 hasConceptScore W2016598746C2781005078 @default.
• W2016598746 hasConceptScore W2016598746C2781258859 @default.
• W2016598746 hasConceptScore W2016598746C42219234 @default.
• W2016598746 hasConceptScore W2016598746C513476851 @default.
• W2016598746 hasConceptScore W2016598746C53910766 @default.
• W2016598746 hasConceptScore W2016598746C71924100 @default.
• W2016598746 hasIssue "4" @default.
• W2016598746 hasLocation W20165987461 @default.
• W2016598746 hasLocation W20165987462 @default.
• W2016598746 hasOpenAccess W2016598746 @default.
• W2016598746 hasPrimaryLocation W20165987461 @default.
• W2016598746 hasRelatedWork W1992503111 @default.
• W2016598746 hasRelatedWork W2027411819 @default.
• W2016598746 hasRelatedWork W2036082219 @default.
• W2016598746 hasRelatedWork W2038221598 @default.
• W2016598746 hasRelatedWork W2054184534 @default.
• W2016598746 hasRelatedWork W2057003203 @default.
• W2016598746 hasRelatedWork W2060872667 @default.
• W2016598746 hasRelatedWork W2081245175 @default.
• W2016598746 hasRelatedWork W2107899720 @default.
• W2016598746 hasRelatedWork W2112684472 @default.
• W2016598746 hasVolume "49" @default.
• W2016598746 isParatext "false" @default.
• W2016598746 isRetracted "false" @default.
• W2016598746 magId "2016598746" @default.
• W2016598746 workType "article" @default.