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- W2016599765 abstract "Abstract In thyroidectomized rats, 3,5,3'-triiodo-thyroformic (TF3), 3,5,3'-triiodo-thyroacetic (TA3) and 3,5.3'-triiodo-thyropropionic (TP3) acids, which are structural analogs of 3,5,3'-triiodo-L-thyronine (LT3), counteract the decrease of mitochondrial glutamate dehydrogenase (GlDH) activity and the increase of mitochondrial isocitrate dehydrogenase (ICDH) and cytoplasmic alcohol dehydrogenase (ADH) activities in liver. The effect of TA3 is similar to that of LT3, those of TP3 and TF3 being, in this order, lower. TF3, TA, and TP3 have no effect on heart mitochondrial ICDH activity, an activity which does not appear to be influenced by thyroidectomy. In vitro, TF3, TA3 and TP3 inhibit GlDH, ICDH and ADH activities when tested either on liver subcellular fractions or on pure enzymes: the effects are more pronounced on GlDH than on ADH or on ICDH. The three iodinated derivatives present differences in the competitive character of the inhibition they exert against the substrate or cosubstrate involved in the differeet enzyme reactions investigated." @default.
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- W2016599765 modified "2023-09-27" @default.
- W2016599765 title "Influence d'analogues structuraux de la triiodo-3,5,3'-l-thyronine sur l'activite de la glutamate deshydrogenase et de l'isocitrate deshydrogenase mitochondriales hepatiques et cardiaques et de l'alcool deshydrogenase hepatique: in vivo et in vitro" @default.
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- W2016599765 doi "https://doi.org/10.1016/0006-2952(75)90006-4" @default.
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