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• W2016603101 abstract "The beta-lactamase inhibitor, sulbactam, was tested for beta-lactamase inhibitory activity in Pseudomonas aeruginosa cells producing various levels of both the MexAB-OprM efflux pump and beta-lactamase. We found that sulbactam lowered the MICs of cefoperazone and piperacillin by inhibiting the beta-lactamase 8-fold in the cell producing a constitutively high level of AmpC-type beta-lactamase and a wild-type level of MexAB-OprM pump compared with that without sulbactam. The MICs of cefoperazone and piperacillin in the cell producing a constitutively high level of both the efflux pump and beta-lactamase under the presence of sulbactam were 8 and 4 times, respectively, lower than that without sulbactam. The MICs of sulbactam in the cell producing a constitutively high and a wild-type level of the efflux pump were 16- and 8-fold higher, respectively, than that in the mutant lacking the efflux pump. We concluded that sulbactam exerts potent beta-lactamase inhibitory activity in the cell producing a high level of efflux pump, in spite of the fact that sulbactam serves as a substrate of the MexAB-OprM pump. Increasing amounts of sulbactam over the weight of beta-lactams further strengthen the effect of beta-lactam antibiotics." @default.
• W2016603101 created "2016-06-24" @default.
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• W2016603101 date "2000-12-01" @default.
• W2016603101 modified "2023-09-25" @default.
• W2016603101 title "Effect of Sulbactam on Anti-Pseudomonal Activity of β-Lactam Antibiotics in Cells Producing Various Levels of the MexAB-OprM Efflux Pump and β-Lactamase" @default.
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• W2016603101 doi "https://doi.org/10.1111/j.1348-0421.2000.tb02595.x" @default.
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