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• W2016603709 abstract "There is no doubt that scaling relations exist between myocardial mass and morphometry of coronary vasculature. The purpose of this study is to quantify several morphological (diameter, length, and volume) and functional (flow) parameters of the coronary arterial tree in relation to myocardial mass. Eight normal porcine hearts of 117–244 g (mean of 177.5 ± 32.7) were used in this study. Various coronary subtrees of the left anterior descending, right coronary, and left circumflex arteries were perfused at pressure of 100 mmHg with different colors of a polymer (Microfil) to obtain rubber casts of arterial trees corresponding to different regions of myocardial mass. Volume, diameter, and cumulative length of coronary arteries were reconstructed from casts to analyze their relationship to the perfused myocardial mass. Volumetric flow was measured in relationship with perfused myocardial mass. Our results show that arterial volume is linearly related to regional myocardial mass, whereas the sum of coronary arterial branch lengths, vessel diameters, and volumetric flow show an ∼3/4, 3/8, and 3/4 power-law relationship, respectively, in relation to myocardial mass. These scaling laws suggest fundamental design principles underlying the structure-function relationship of the coronary arterial tree that may facilitate diagnosis and management of diffuse coronary artery disease." @default.
• W2016603709 created "2016-06-24" @default.
• W2016603709 creator A5062194902 @default.
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• W2016603709 date "2008-05-01" @default.
• W2016603709 modified "2023-10-16" @default.
• W2016603709 title "Scaling of myocardial mass to flow and morphometry of coronary arteries" @default.
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• W2016603709 doi "https://doi.org/10.1152/japplphysiol.01261.2007" @default.
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