Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016604995> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2016604995 endingPage "238" @default.
- W2016604995 startingPage "237" @default.
- W2016604995 abstract "The Gorham-Stout Syndrome is a rare condition in which spontaneous, progressive resorption of bone occurs. Even though the prognosis of the condition is generally considered to be good, Gorham-Stout syndrome can cause severe debilitation. In approximately 13% of recorded cases, death ensues. The treatment modalities for Gorham-Stout Syndrome include surgery, radiation therapy, anti-osteoclastic medications, however there is no known successful treatment. To date, the etiology of Gorham-Stout Syndrome is still controversial. However, general consensus on the importance of the derangement of osteoclastic activity and angiomatosis of blood vessels. Thus, local deliver of anti-osteoclastic and anti-angiogenic agents may be of great interest for the treatment of Gorham-Stout Syndrome. Bisphosphonates are potent in inhibiting osteoclast activity and promoting apoptosis, which has been widely used for the treatment of osteoporosis and osteolysis diseases and proved to be able to decrease the speed of bone destruction in Gorham-Stout Syndrome through systemic administration. In addition to its anti-osteolytic effect, bisphosphonates are currently shown to be capable of anti-angiogenesis and induction of apoptosis in tumor cells. Furthermore biocompatible calcium phosphate which is widely used for bone reconstruction in clinical has also been reported to be a suitable carrier for loading and releasing of bioactive bisphosphonates. Therefore, we hypothesis that local deliver of bisphosphonates by calcium phosphate may be a potential treatment of Gorham-Stout Syndrome." @default.
- W2016604995 created "2016-06-24" @default.
- W2016604995 creator A5045069173 @default.
- W2016604995 creator A5061711797 @default.
- W2016604995 creator A5076828350 @default.
- W2016604995 creator A5083247969 @default.
- W2016604995 creator A5085701664 @default.
- W2016604995 date "2011-02-01" @default.
- W2016604995 modified "2023-09-26" @default.
- W2016604995 title "Could local deliver of bisphosphonates be a new therapeutic choice for Gorham–Stout syndrome?" @default.
- W2016604995 cites W192636272 @default.
- W2016604995 cites W1964513315 @default.
- W2016604995 cites W1965745056 @default.
- W2016604995 cites W1967434452 @default.
- W2016604995 cites W1986696138 @default.
- W2016604995 cites W1989621786 @default.
- W2016604995 cites W1991446561 @default.
- W2016604995 cites W2024086761 @default.
- W2016604995 cites W2029215095 @default.
- W2016604995 cites W2029982108 @default.
- W2016604995 cites W2030146536 @default.
- W2016604995 cites W2040296040 @default.
- W2016604995 cites W2052788750 @default.
- W2016604995 cites W2059695146 @default.
- W2016604995 cites W2068718091 @default.
- W2016604995 cites W2070110061 @default.
- W2016604995 cites W2122732781 @default.
- W2016604995 cites W2144089549 @default.
- W2016604995 cites W2144860907 @default.
- W2016604995 cites W2151303412 @default.
- W2016604995 cites W2160066899 @default.
- W2016604995 cites W2160145148 @default.
- W2016604995 cites W4294837395 @default.
- W2016604995 doi "https://doi.org/10.1016/j.mehy.2010.10.006" @default.
- W2016604995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21044823" @default.
- W2016604995 hasPublicationYear "2011" @default.
- W2016604995 type Work @default.
- W2016604995 sameAs 2016604995 @default.
- W2016604995 citedByCount "12" @default.
- W2016604995 countsByYear W20166049952012 @default.
- W2016604995 countsByYear W20166049952013 @default.
- W2016604995 countsByYear W20166049952014 @default.
- W2016604995 countsByYear W20166049952017 @default.
- W2016604995 countsByYear W20166049952018 @default.
- W2016604995 countsByYear W20166049952020 @default.
- W2016604995 countsByYear W20166049952022 @default.
- W2016604995 crossrefType "journal-article" @default.
- W2016604995 hasAuthorship W2016604995A5045069173 @default.
- W2016604995 hasAuthorship W2016604995A5061711797 @default.
- W2016604995 hasAuthorship W2016604995A5076828350 @default.
- W2016604995 hasAuthorship W2016604995A5083247969 @default.
- W2016604995 hasAuthorship W2016604995A5085701664 @default.
- W2016604995 hasConcept C126322002 @default.
- W2016604995 hasConcept C137627325 @default.
- W2016604995 hasConcept C141071460 @default.
- W2016604995 hasConcept C142724271 @default.
- W2016604995 hasConcept C170493617 @default.
- W2016604995 hasConcept C2776033226 @default.
- W2016604995 hasConcept C2776333679 @default.
- W2016604995 hasConcept C2776541429 @default.
- W2016604995 hasConcept C2781282405 @default.
- W2016604995 hasConcept C2908539429 @default.
- W2016604995 hasConcept C502942594 @default.
- W2016604995 hasConcept C673006 @default.
- W2016604995 hasConcept C71924100 @default.
- W2016604995 hasConceptScore W2016604995C126322002 @default.
- W2016604995 hasConceptScore W2016604995C137627325 @default.
- W2016604995 hasConceptScore W2016604995C141071460 @default.
- W2016604995 hasConceptScore W2016604995C142724271 @default.
- W2016604995 hasConceptScore W2016604995C170493617 @default.
- W2016604995 hasConceptScore W2016604995C2776033226 @default.
- W2016604995 hasConceptScore W2016604995C2776333679 @default.
- W2016604995 hasConceptScore W2016604995C2776541429 @default.
- W2016604995 hasConceptScore W2016604995C2781282405 @default.
- W2016604995 hasConceptScore W2016604995C2908539429 @default.
- W2016604995 hasConceptScore W2016604995C502942594 @default.
- W2016604995 hasConceptScore W2016604995C673006 @default.
- W2016604995 hasConceptScore W2016604995C71924100 @default.
- W2016604995 hasIssue "2" @default.
- W2016604995 hasLocation W20166049951 @default.
- W2016604995 hasLocation W20166049952 @default.
- W2016604995 hasOpenAccess W2016604995 @default.
- W2016604995 hasPrimaryLocation W20166049951 @default.
- W2016604995 hasRelatedWork W1948868238 @default.
- W2016604995 hasRelatedWork W1986968138 @default.
- W2016604995 hasRelatedWork W1996006050 @default.
- W2016604995 hasRelatedWork W2006625472 @default.
- W2016604995 hasRelatedWork W2028064456 @default.
- W2016604995 hasRelatedWork W2092339321 @default.
- W2016604995 hasRelatedWork W2117150911 @default.
- W2016604995 hasRelatedWork W2161005316 @default.
- W2016604995 hasRelatedWork W2412458747 @default.
- W2016604995 hasRelatedWork W2907221685 @default.
- W2016604995 hasVolume "76" @default.
- W2016604995 isParatext "false" @default.
- W2016604995 isRetracted "false" @default.
- W2016604995 magId "2016604995" @default.
- W2016604995 workType "article" @default.