Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016605000> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2016605000 abstract "Abstract The buccal absorption of ketobemidone, a strong narcotic analgesic, and various carboxylate and carbonate ester prodrugs was studied in rats. The compounds were administered in the form of aqueous solutions of pH 7.4. The absolute bioavailability of ketobemidone following buccal dosing was 26% whereas the bioavailability of ketobemidone following buccal administration of the prodrugs ranged from 37 to 98%. The highest bioavailability was obtained with the ethyl carbonate ester. An apparent parabolic correlation between bioavailability and lipophilicity of the compounds was seen. All esters were rapidly hydrolyzed to ketobemidone after both buccal and intravenous administration. The acute toxicity of the esters after i.v. administration to mice and rats was similar to that of the parent drug. It is concluded that esterification of the phenolic hydroxyl group in ketobemidone to give a more lipophilic prodrug may be a useful approach to improve the buccal delivery of this analgesic." @default.
- W2016605000 created "2016-06-24" @default.
- W2016605000 creator A5015329870 @default.
- W2016605000 creator A5020853632 @default.
- W2016605000 creator A5029118094 @default.
- W2016605000 creator A5070555109 @default.
- W2016605000 creator A5080010636 @default.
- W2016605000 date "1992-12-01" @default.
- W2016605000 modified "2023-09-24" @default.
- W2016605000 title "Buccal absorption of ketobemidone and various ester prodrugs in the rat" @default.
- W2016605000 cites W1637109054 @default.
- W2016605000 cites W1970411405 @default.
- W2016605000 cites W1976881102 @default.
- W2016605000 cites W1992005415 @default.
- W2016605000 cites W2010062473 @default.
- W2016605000 cites W2049295401 @default.
- W2016605000 cites W2067380828 @default.
- W2016605000 cites W2077752533 @default.
- W2016605000 cites W2087526401 @default.
- W2016605000 cites W2087893871 @default.
- W2016605000 cites W2092169396 @default.
- W2016605000 cites W2167359143 @default.
- W2016605000 cites W2171074980 @default.
- W2016605000 cites W2419336297 @default.
- W2016605000 cites W884616459 @default.
- W2016605000 doi "https://doi.org/10.1016/0378-5173(92)90322-s" @default.
- W2016605000 hasPublicationYear "1992" @default.
- W2016605000 type Work @default.
- W2016605000 sameAs 2016605000 @default.
- W2016605000 citedByCount "7" @default.
- W2016605000 countsByYear W20166050002016 @default.
- W2016605000 crossrefType "journal-article" @default.
- W2016605000 hasAuthorship W2016605000A5015329870 @default.
- W2016605000 hasAuthorship W2016605000A5020853632 @default.
- W2016605000 hasAuthorship W2016605000A5029118094 @default.
- W2016605000 hasAuthorship W2016605000A5070555109 @default.
- W2016605000 hasAuthorship W2016605000A5080010636 @default.
- W2016605000 hasConcept C108215921 @default.
- W2016605000 hasConcept C112705442 @default.
- W2016605000 hasConcept C121332964 @default.
- W2016605000 hasConcept C125287762 @default.
- W2016605000 hasConcept C181389837 @default.
- W2016605000 hasConcept C185592680 @default.
- W2016605000 hasConcept C195735259 @default.
- W2016605000 hasConcept C201399114 @default.
- W2016605000 hasConcept C24890656 @default.
- W2016605000 hasConcept C2777056448 @default.
- W2016605000 hasConcept C2780820201 @default.
- W2016605000 hasConcept C55493867 @default.
- W2016605000 hasConcept C71240020 @default.
- W2016605000 hasConcept C71924100 @default.
- W2016605000 hasConcept C94412978 @default.
- W2016605000 hasConcept C98274493 @default.
- W2016605000 hasConceptScore W2016605000C108215921 @default.
- W2016605000 hasConceptScore W2016605000C112705442 @default.
- W2016605000 hasConceptScore W2016605000C121332964 @default.
- W2016605000 hasConceptScore W2016605000C125287762 @default.
- W2016605000 hasConceptScore W2016605000C181389837 @default.
- W2016605000 hasConceptScore W2016605000C185592680 @default.
- W2016605000 hasConceptScore W2016605000C195735259 @default.
- W2016605000 hasConceptScore W2016605000C201399114 @default.
- W2016605000 hasConceptScore W2016605000C24890656 @default.
- W2016605000 hasConceptScore W2016605000C2777056448 @default.
- W2016605000 hasConceptScore W2016605000C2780820201 @default.
- W2016605000 hasConceptScore W2016605000C55493867 @default.
- W2016605000 hasConceptScore W2016605000C71240020 @default.
- W2016605000 hasConceptScore W2016605000C71924100 @default.
- W2016605000 hasConceptScore W2016605000C94412978 @default.
- W2016605000 hasConceptScore W2016605000C98274493 @default.
- W2016605000 hasLocation W20166050001 @default.
- W2016605000 hasOpenAccess W2016605000 @default.
- W2016605000 hasPrimaryLocation W20166050001 @default.
- W2016605000 hasRelatedWork W1582088281 @default.
- W2016605000 hasRelatedWork W181652318 @default.
- W2016605000 hasRelatedWork W1976881102 @default.
- W2016605000 hasRelatedWork W1987285363 @default.
- W2016605000 hasRelatedWork W1992005415 @default.
- W2016605000 hasRelatedWork W1994605182 @default.
- W2016605000 hasRelatedWork W2028532915 @default.
- W2016605000 hasRelatedWork W2035484214 @default.
- W2016605000 hasRelatedWork W2051858567 @default.
- W2016605000 hasRelatedWork W2054449983 @default.
- W2016605000 hasRelatedWork W2067380828 @default.
- W2016605000 hasRelatedWork W2081329359 @default.
- W2016605000 hasRelatedWork W2089077297 @default.
- W2016605000 hasRelatedWork W2093487867 @default.
- W2016605000 hasRelatedWork W2128193407 @default.
- W2016605000 hasRelatedWork W2410722511 @default.
- W2016605000 hasRelatedWork W386498275 @default.
- W2016605000 hasRelatedWork W43478572 @default.
- W2016605000 hasRelatedWork W75416832 @default.
- W2016605000 hasRelatedWork W2471399209 @default.
- W2016605000 isParatext "false" @default.
- W2016605000 isRetracted "false" @default.
- W2016605000 magId "2016605000" @default.
- W2016605000 workType "article" @default.