Matches in SemOpenAlex for { <https://semopenalex.org/work/W201660610> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W201660610 abstract "Kaempferia angustifolia, K rotunda (Zingiberaceae), Spennacoce articularis and S.exilis (Rubiaceae) were chosen since they have long been used traditionally inmedicinal treatment. In this research, isolation and separation work had been carried outusing various solvents and chromatographic methods. The structure of these compoundswere determined by using spectroscopic methods such as ineared (IR), nuclearmagnetic resonance ('H, 13C and 2D- NMR), mass spectrometry (MS) and bycomparison with the data reported previously. The crude extracts and some of theisolated compounds were subjected to the biological activity test: antioxidant, antimicrobialtests, cytotoxic screening and larvicidal activity.Extracts fiom Kaempferia angush~oliah ave yielded a new compound angustifolienol(58), together with seven other compounds; crotepoxide (33), p-sitosterol (a),boesenboxide (M), 2'-hydroxy-4, 4', 6'-trimethoxychalcone (Xi), 6-methylzeylenol(59), and sucrose (60), and zeylenol(35). Frationation of extracts fiom K. rotunda hasyielded five pure compounds; crotepoxide (33), tetracosanoic acid (61), benzoic acid(62), stigmasterol (45) and p-sitosterol (44). Both tetracosanoic acid (61) and benzoicacid (62) are new to species. Extracts fiom S. art'iculm's gave two pure compounds,identified as ursolic acid (63) and stigmasterol (45). While the extracts from S. exilisgave four compounds, benzo[g]isoquinoline-5,IOdione (64), stigmasterol (49,hexadecanoic acid (65) and ursolic acid (63). Phytochemical studies on later species hadnever been reported before.Acetylations of new compound, angustifolienol (58) gave two derivatives,triacetoxyangustifolienol (66) and diacetoxyangustifolienol (67). Both are newcompounds, and have never been reported previously either as natural product orsynthesized compounds.The major constituents of the essential oil of K. angustifolia was DL- camphor (20.57%), while the major constituent of K. rotunda was benzyl benzoate (49.84 %). Themajor constituent of the essential oil of S. articularis was phytol(10.31 %), whilethe major constituent of S. exilis was oleic acid (20.9 %).Cytotoxic screening showed that all the crude extracts of K angustiijolia and K. rotunabwere not cytotoxic against HL-60 cell line. However, pure compounds of K.angu~hyolia showed strong activity. All crude extracts of S. articularis and S. exilis(except hexane extract of S. exilis) and ursolic acid (63) were strongly cytotoxic towardsHL-60 and MCF-7 cell lines. All extracts and most of the pure compounds weresubjected to four strains of microbes (MRSA, Pseudomonas aeruginosa, Salmonellatyphimurium and Bacillus subtilis) in the antimicrobial test. Pet. ether extracts fiomKaempferia species, all extracts fiom S. exilis and boesenboxide (34) were activetowards some microbes. In antioxidant assay, K rotunda was more active thanKaempferia angustiyolia while both Spennacoce species were moderately active.Besides that, some of the compounds from Kaempferia angustzyolia were subjected tothe antioxidant assay and showed stronger antioxidant activity than a- tocopherol. Inaddition, all plants also showed moderate to low larvicidal activity." @default.
- W201660610 created "2016-06-24" @default.
- W201660610 creator A5071544952 @default.
- W201660610 date "2006-01-01" @default.
- W201660610 modified "2023-09-23" @default.
- W201660610 title "Chemical Constituents and Biological Activity of Kaempferia Angustifolia, K. Rotunda,Spermacoce Articularis and S. Exilis" @default.
- W201660610 hasPublicationYear "2006" @default.
- W201660610 type Work @default.
- W201660610 sameAs 201660610 @default.
- W201660610 citedByCount "0" @default.
- W201660610 crossrefType "dissertation" @default.
- W201660610 hasAuthorship W201660610A5071544952 @default.
- W201660610 hasConcept C134550120 @default.
- W201660610 hasConcept C178790620 @default.
- W201660610 hasConcept C185592680 @default.
- W201660610 hasConcept C195475562 @default.
- W201660610 hasConcept C2776789170 @default.
- W201660610 hasConcept C2777442669 @default.
- W201660610 hasConcept C2778016309 @default.
- W201660610 hasConcept C2778844314 @default.
- W201660610 hasConcept C2779513101 @default.
- W201660610 hasConcept C43617362 @default.
- W201660610 hasConcept C55493867 @default.
- W201660610 hasConcept C556039675 @default.
- W201660610 hasConcept C71240020 @default.
- W201660610 hasConcept C71924100 @default.
- W201660610 hasConceptScore W201660610C134550120 @default.
- W201660610 hasConceptScore W201660610C178790620 @default.
- W201660610 hasConceptScore W201660610C185592680 @default.
- W201660610 hasConceptScore W201660610C195475562 @default.
- W201660610 hasConceptScore W201660610C2776789170 @default.
- W201660610 hasConceptScore W201660610C2777442669 @default.
- W201660610 hasConceptScore W201660610C2778016309 @default.
- W201660610 hasConceptScore W201660610C2778844314 @default.
- W201660610 hasConceptScore W201660610C2779513101 @default.
- W201660610 hasConceptScore W201660610C43617362 @default.
- W201660610 hasConceptScore W201660610C55493867 @default.
- W201660610 hasConceptScore W201660610C556039675 @default.
- W201660610 hasConceptScore W201660610C71240020 @default.
- W201660610 hasConceptScore W201660610C71924100 @default.
- W201660610 hasLocation W2016606101 @default.
- W201660610 hasOpenAccess W201660610 @default.
- W201660610 hasPrimaryLocation W2016606101 @default.
- W201660610 hasRelatedWork W101879120 @default.
- W201660610 hasRelatedWork W144601588 @default.
- W201660610 hasRelatedWork W174481208 @default.
- W201660610 hasRelatedWork W180741768 @default.
- W201660610 hasRelatedWork W207508338 @default.
- W201660610 hasRelatedWork W2188850141 @default.
- W201660610 hasRelatedWork W2289321197 @default.
- W201660610 hasRelatedWork W2578901664 @default.
- W201660610 hasRelatedWork W2728876176 @default.
- W201660610 hasRelatedWork W2953644178 @default.
- W201660610 hasRelatedWork W2995834097 @default.
- W201660610 hasRelatedWork W3011387591 @default.
- W201660610 hasRelatedWork W3119746696 @default.
- W201660610 hasRelatedWork W3121992727 @default.
- W201660610 hasRelatedWork W44487869 @default.
- W201660610 hasRelatedWork W55479647 @default.
- W201660610 hasRelatedWork W592876397 @default.
- W201660610 hasRelatedWork W11871773 @default.
- W201660610 hasRelatedWork W2510902976 @default.
- W201660610 hasRelatedWork W2741205084 @default.
- W201660610 isParatext "false" @default.
- W201660610 isRetracted "false" @default.
- W201660610 magId "201660610" @default.
- W201660610 workType "dissertation" @default.