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- W2016609872 abstract "Brain asymmetry, ascertained by anatomical, neurochemical, and functional data, is involved in the regulation of physiological systems including the immune system. Two different approaches have been used to demonstrate the influence of brain asymmetry on immune functional activity and cytokine production. The first one, formerly studied in laboratory animals, consists of measuring the immune effects of left or right ablations of the brain cortex. T-cell functions are depressed after left-side lesions but enhanced after symmetrical right-side lesions. These results have been recently confirmed in patients after stroke or surgical ablations for epilepsy. These data lead to the conclusion that in normal conditions the right hemisphere has a depressive effect on T-cell functions whereas the left hemisphere has a stimulating effect.The second approach to the study of brain asymmetry results from clinical observations where left-handedness has been associated with a high incidence of immune disorders. An association between functional lateralization and immune reactivity has been clearly demonstrated in animals, mainly using paw preference as an index of lateralization. This experimental approach, which avoids the phenomenon of neural plasticity observed after brain lesions, enables the study of mechanisms whereby the brain can asymmetrically modulate the activity of the immune system. Preliminary experiments suggest that the roles of different brain hemispheres on immune responses result from an asymmetrical brain control of the sympathetic nervous system.Cytokines produced in the periphery by the immune system function as mediators of an afferent pathway to the brain and are considered part of a neuroendocrine–immune signaling system. It is well known that cytokines can modulate the neuroendocrine systems and brain metabolism and can induce behavioral alterations. Interestingly, all these effects of cytokines depend on lateralization." @default.
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- W2016609872 date "1987-03-01" @default.
- W2016609872 modified "2023-09-26" @default.
- W2016609872 title "Lymphocyte subsets of left-handers" @default.
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- W2016609872 doi "https://doi.org/10.1016/0889-1591(87)90004-3" @default.
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