Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016609963> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2016609963 endingPage "1343" @default.
- W2016609963 startingPage "1336" @default.
- W2016609963 abstract "OBJECTIVES The goal of this study was to assess the short- and long-term efficacy of different thrombolytic therapy regimens in patients with leg or pelvic deep venous thrombosis (DVT). BACKGROUND It is unclear whether locoregional or systemic thrombolysis is superior in treating acute leg DVT or even whether lysis is more effective than anticoagulation therapy in preventing postthrombotic syndrome. METHODS A total of 250 patients averaging 40 years of age with acute DVT were randomized into five groups to receive full heparinization (1,000 IU/h) and compression treatment, with four groups also administered locoregional tissue plasminogen activator (20 mg/day) or urokinase (100,000 IU/day) or systemic streptokinase (3,000,000 IU daily) or urokinase (5,000,000 IU daily). All groups then received anticoagulation and compression treatment for one year. Primary efficacy criteria included the change after one year in the number of closed vein segments and the occurrence of postthrombotic syndrome. RESULTS Systemic thrombolytic therapy significantly reduced the number of closed vein segments after 12 months in patients with acute DVT compared with conventional treatment (p < 0.05). Postthrombotic syndrome also occurred with less frequency in systemically treated patients versus controls (p < 0.001). High-dose thrombolysis led to better rates of complete recanalization after seven days (p < 0.01) than locoregional lysis. However, 12 patients receiving thrombolysis (9 systemic, 3 local) suffered major bleeding complications; 9 patients on systemic treatment developed pulmonary emboli. CONCLUSIONS Systemic thrombolytic treatment for acute DVT achieved a significantly better short- and long-term clinical outcome than conventional heparin/anticoagulation therapy but at the expense of a serious increase in major bleeding and pulmonary emboli. Given the inherent risks for such serious complications, systemic thrombolysis, although effective, should be used selectively in limb-threatening thrombotic situations." @default.
- W2016609963 created "2016-06-24" @default.
- W2016609963 creator A5004062994 @default.
- W2016609963 creator A5011304517 @default.
- W2016609963 creator A5011389445 @default.
- W2016609963 creator A5017946455 @default.
- W2016609963 creator A5045822517 @default.
- W2016609963 creator A5053155088 @default.
- W2016609963 creator A5056375693 @default.
- W2016609963 date "2000-10-01" @default.
- W2016609963 modified "2023-10-12" @default.
- W2016609963 title "Short- and long-term results after thrombolytic treatment of deep venous thrombosis" @default.
- W2016609963 cites W1980367966 @default.
- W2016609963 cites W1996085317 @default.
- W2016609963 cites W1997438601 @default.
- W2016609963 cites W2001563266 @default.
- W2016609963 cites W2007943712 @default.
- W2016609963 cites W2012042329 @default.
- W2016609963 cites W2055536234 @default.
- W2016609963 cites W2125816252 @default.
- W2016609963 cites W2141615647 @default.
- W2016609963 cites W2464710386 @default.
- W2016609963 cites W4234933336 @default.
- W2016609963 cites W4247399647 @default.
- W2016609963 cites W4294109446 @default.
- W2016609963 doi "https://doi.org/10.1016/s0735-1097(00)00863-9" @default.
- W2016609963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11028492" @default.
- W2016609963 hasPublicationYear "2000" @default.
- W2016609963 type Work @default.
- W2016609963 sameAs 2016609963 @default.
- W2016609963 citedByCount "146" @default.
- W2016609963 countsByYear W20166099632012 @default.
- W2016609963 countsByYear W20166099632013 @default.
- W2016609963 countsByYear W20166099632014 @default.
- W2016609963 countsByYear W20166099632015 @default.
- W2016609963 countsByYear W20166099632016 @default.
- W2016609963 countsByYear W20166099632017 @default.
- W2016609963 countsByYear W20166099632018 @default.
- W2016609963 countsByYear W20166099632019 @default.
- W2016609963 countsByYear W20166099632020 @default.
- W2016609963 countsByYear W20166099632021 @default.
- W2016609963 countsByYear W20166099632022 @default.
- W2016609963 countsByYear W20166099632023 @default.
- W2016609963 crossrefType "journal-article" @default.
- W2016609963 hasAuthorship W2016609963A5004062994 @default.
- W2016609963 hasAuthorship W2016609963A5011304517 @default.
- W2016609963 hasAuthorship W2016609963A5011389445 @default.
- W2016609963 hasAuthorship W2016609963A5017946455 @default.
- W2016609963 hasAuthorship W2016609963A5045822517 @default.
- W2016609963 hasAuthorship W2016609963A5053155088 @default.
- W2016609963 hasAuthorship W2016609963A5056375693 @default.
- W2016609963 hasBestOaLocation W20166099631 @default.
- W2016609963 hasConcept C126322002 @default.
- W2016609963 hasConcept C141071460 @default.
- W2016609963 hasConcept C2776265017 @default.
- W2016609963 hasConcept C2776336681 @default.
- W2016609963 hasConcept C2776892390 @default.
- W2016609963 hasConcept C2777202286 @default.
- W2016609963 hasConcept C2778555097 @default.
- W2016609963 hasConcept C2778959117 @default.
- W2016609963 hasConcept C2779581417 @default.
- W2016609963 hasConcept C2780011451 @default.
- W2016609963 hasConcept C2780868729 @default.
- W2016609963 hasConcept C500558357 @default.
- W2016609963 hasConcept C71924100 @default.
- W2016609963 hasConceptScore W2016609963C126322002 @default.
- W2016609963 hasConceptScore W2016609963C141071460 @default.
- W2016609963 hasConceptScore W2016609963C2776265017 @default.
- W2016609963 hasConceptScore W2016609963C2776336681 @default.
- W2016609963 hasConceptScore W2016609963C2776892390 @default.
- W2016609963 hasConceptScore W2016609963C2777202286 @default.
- W2016609963 hasConceptScore W2016609963C2778555097 @default.
- W2016609963 hasConceptScore W2016609963C2778959117 @default.
- W2016609963 hasConceptScore W2016609963C2779581417 @default.
- W2016609963 hasConceptScore W2016609963C2780011451 @default.
- W2016609963 hasConceptScore W2016609963C2780868729 @default.
- W2016609963 hasConceptScore W2016609963C500558357 @default.
- W2016609963 hasConceptScore W2016609963C71924100 @default.
- W2016609963 hasIssue "4" @default.
- W2016609963 hasLocation W20166099631 @default.
- W2016609963 hasLocation W20166099632 @default.
- W2016609963 hasOpenAccess W2016609963 @default.
- W2016609963 hasPrimaryLocation W20166099631 @default.
- W2016609963 hasRelatedWork W1726035242 @default.
- W2016609963 hasRelatedWork W1811749912 @default.
- W2016609963 hasRelatedWork W2359139099 @default.
- W2016609963 hasRelatedWork W2368737360 @default.
- W2016609963 hasRelatedWork W2397197335 @default.
- W2016609963 hasRelatedWork W2399672512 @default.
- W2016609963 hasRelatedWork W2411536827 @default.
- W2016609963 hasRelatedWork W2421632477 @default.
- W2016609963 hasRelatedWork W2443057861 @default.
- W2016609963 hasRelatedWork W4255966750 @default.
- W2016609963 hasVolume "36" @default.
- W2016609963 isParatext "false" @default.
- W2016609963 isRetracted "false" @default.
- W2016609963 magId "2016609963" @default.
- W2016609963 workType "article" @default.