FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016618130> ?p ?o ?g. }

• W2016618130 endingPage "19" @default.
• W2016618130 startingPage "12" @default.
• W2016618130 abstract "Methylene blue (MB), a water-soluble cationic dye widely used in the clinic, is known to photosensitize the generation of cytotoxic singlet oxygen efficiently, and thus, has attracted interest as a potential drug for photodynamic therapy (PDT). However, its use for the in vivo PDT of cancer has been limited due to the inherently poor cell/tissue accumulation and low biological stability in the free molecular form. Here, we report a simple and biocompatible nanocomplex formulation of MB (NanoMB) that is useful for in vivo locoregional cancer treatment by PDT. NanoMB particles were constructed through the self-assembly of clinically usable molecules (MB, fatty acid and a clinically approved polymer surfactant) directed by the dual (electrostatic and hydrophobic) interactions between the ternary constituents. The nanocomplexed MB showed greatly enhanced cell internalization while keeping the photosensitization efficiency as high as free MB, leading to distinctive phototoxicity toward cancer cells. When administered to human breast cancer xenograft mice by peritumoral injection, NanoMB was capable of facile penetration into the tumor followed by cancer cell accumulation, as examined in vivo and histologically with the near-infrared fluorescence signal of MB. The quintuple PDT treatment by a combination of peritumorally injected NanoMB and selective laser irradiation suppressed the tumor volume efficaciously, demonstrating potential of NanoMB-based PDT as a biocompatible and safe method for adjuvant locoregional cancer treatment." @default.
• W2016618130 created "2016-06-24" @default.
• W2016618130 creator A5008905015 @default.
• W2016618130 creator A5026999592 @default.
• W2016618130 creator A5055388143 @default.
• W2016618130 creator A5065772535 @default.
• W2016618130 creator A5072797132 @default.
• W2016618130 creator A5073866582 @default.
• W2016618130 creator A5080903094 @default.
• W2016618130 creator A5090175489 @default.
• W2016618130 date "2015-07-01" @default.
• W2016618130 modified "2023-10-03" @default.
• W2016618130 title "Directed molecular assembly into a biocompatible photosensitizing nanocomplex for locoregional photodynamic therapy" @default.
• W2016618130 cites W1596848781 @default.
• W2016618130 cites W1941128194 @default.
• W2016618130 cites W1964603841 @default.
• W2016618130 cites W1968277012 @default.
• W2016618130 cites W1971292240 @default.
• W2016618130 cites W1972407019 @default.
• W2016618130 cites W1977979628 @default.
• W2016618130 cites W1979027053 @default.
• W2016618130 cites W1979828007 @default.
• W2016618130 cites W1988497535 @default.
• W2016618130 cites W1992177385 @default.
• W2016618130 cites W1993093621 @default.
• W2016618130 cites W1999102128 @default.
• W2016618130 cites W1999248402 @default.
• W2016618130 cites W2003539095 @default.
• W2016618130 cites W2004197996 @default.
• W2016618130 cites W2004381954 @default.
• W2016618130 cites W2005956598 @default.
• W2016618130 cites W2008536525 @default.
• W2016618130 cites W2013993312 @default.
• W2016618130 cites W2015118757 @default.
• W2016618130 cites W2027303551 @default.
• W2016618130 cites W2030935286 @default.
• W2016618130 cites W2038974631 @default.
• W2016618130 cites W2041458287 @default.
• W2016618130 cites W2050105091 @default.
• W2016618130 cites W2054496327 @default.
• W2016618130 cites W2061450291 @default.
• W2016618130 cites W2070263056 @default.
• W2016618130 cites W2093231351 @default.
• W2016618130 cites W2100903105 @default.
• W2016618130 cites W2114012485 @default.
• W2016618130 cites W2117570650 @default.
• W2016618130 cites W2124531971 @default.
• W2016618130 cites W2125094267 @default.
• W2016618130 cites W2133203116 @default.
• W2016618130 cites W2134539328 @default.
• W2016618130 cites W2143856400 @default.
• W2016618130 cites W2153680912 @default.
• W2016618130 cites W2155248907 @default.
• W2016618130 cites W2161900304 @default.
• W2016618130 cites W2324729990 @default.
• W2016618130 cites W2327253214 @default.
• W2016618130 cites W4211024586 @default.
• W2016618130 cites W4254269439 @default.
• W2016618130 doi "https://doi.org/10.1016/j.jconrel.2015.04.011" @default.
• W2016618130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25872152" @default.
• W2016618130 hasPublicationYear "2015" @default.
• W2016618130 type Work @default.
• W2016618130 sameAs 2016618130 @default.
• W2016618130 citedByCount "24" @default.
• W2016618130 countsByYear W20166181302015 @default.
• W2016618130 countsByYear W20166181302016 @default.
• W2016618130 countsByYear W20166181302017 @default.
• W2016618130 countsByYear W20166181302018 @default.
• W2016618130 countsByYear W20166181302019 @default.
• W2016618130 countsByYear W20166181302020 @default.
• W2016618130 countsByYear W20166181302021 @default.
• W2016618130 countsByYear W20166181302022 @default.
• W2016618130 crossrefType "journal-article" @default.
• W2016618130 hasAuthorship W2016618130A5008905015 @default.
• W2016618130 hasAuthorship W2016618130A5026999592 @default.
• W2016618130 hasAuthorship W2016618130A5055388143 @default.
• W2016618130 hasAuthorship W2016618130A5065772535 @default.
• W2016618130 hasAuthorship W2016618130A5072797132 @default.
• W2016618130 hasAuthorship W2016618130A5073866582 @default.
• W2016618130 hasAuthorship W2016618130A5080903094 @default.
• W2016618130 hasAuthorship W2016618130A5090175489 @default.
• W2016618130 hasConcept C121608353 @default.
• W2016618130 hasConcept C12554922 @default.
• W2016618130 hasConcept C126322002 @default.
• W2016618130 hasConcept C1318750 @default.
• W2016618130 hasConcept C136229726 @default.
• W2016618130 hasConcept C150903083 @default.
• W2016618130 hasConcept C171250308 @default.
• W2016618130 hasConcept C178790620 @default.
• W2016618130 hasConcept C182606246 @default.
• W2016618130 hasConcept C185592680 @default.
• W2016618130 hasConcept C192562407 @default.
• W2016618130 hasConcept C202751555 @default.
• W2016618130 hasConcept C20639190 @default.
• W2016618130 hasConcept C207001950 @default.
• W2016618130 hasConcept C2777292972 @default.
• W2016618130 hasConcept C2777516457 @default.
• W2016618130 hasConcept C2781323092 @default.

• next