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• W2016631105 endingPage "15962" @default.
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• W2016631105 abstract "Drosophila responds to infection by producing a broad range of antimicrobial agents in the fat body and more restricted responses in tissues such as the gut, trachea, and malpighian tubules. The regulation of antimicrobial genes in larval fat depends on linked Rel/NF-κB and GATA binding sites. Serpent functions as the major GATA transcription factor in the larval fat body. However, the transcriptional regulation of other tissue-specific responses is less well understood. Here, we present evidence that dGATAe regulates antimicrobial gene expression in the midgut. Regulatory regions for antimicrobial genes Diptericin and Metchnikowin require GATA sites for activation in the midgut, where Grain (dGATAc), dGATAd, and dGATAe are expressed in overlapping domains. Ectopic expression of dGATAe in the larval fat body, where it is normally absent, causes dramatic up-regulation of numerous innate immunity and gut genes, as judged by microarray analysis and in situ hybridization. Ectopic dGATAe also causes a host of symptoms reminiscent of hyperactive Toll (Toll 10b ) mutants, but without apparent activation of Toll signaling. Based on this evidence we propose that dGATAe mediates a Toll-independent immune response in the midgut, providing a window into the first and perhaps most ancient line of animal defense." @default.
• W2016631105 created "2016-06-24" @default.
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• W2016631105 date "2006-10-24" @default.
• W2016631105 modified "2023-10-01" @default.
• W2016631105 title "GATA factors participate in tissue-specific immune responses in <i>Drosophila</i> larvae" @default.
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• W2016631105 doi "https://doi.org/10.1073/pnas.0607608103" @default.
• W2016631105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1635109" @default.
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