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• W2016635618 abstract "We measured the density and affinity of muscarinic cholinergic receptors (MR) in 29 chronic progressive and ten stable multiple sclerosis (MS) patients and 27 control subjects using [3H]N-methyl-scopolamine. The density of MR on CD4+ lymphocytes was significantly higher in chronic progressive MS (CPMS) than in controls (7.9 ± 0.7 vs. 4.5 ± 0.4 fmol/106 cells, p < 0.001). Stable patients did not differ significantly from control subjects. Receptors of the M1 subtype were measured on CD4+ lymphocytes of nine patients and seven controls with the selective antagonist [3H]methylpirenzepine: M1/total receptor ratio was 64.1% in CPMS and 81.2% in controls, suggesting a selective increase of M2-type MR in CPMS. The findings may relate to parasympathetic denervation hypersensitivity of lymphocytes or to lymphocyte activation which is known to be associated with increased MR number." @default.
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• W2016635618 date "1992-02-01" @default.
• W2016635618 modified "2023-09-27" @default.
• W2016635618 title "Increased muscarinic cholinergic receptor density on CD4+ lymphocytes in progressive multiple sclerosis" @default.
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• W2016635618 doi "https://doi.org/10.1016/0165-5728(92)90048-p" @default.
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