Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016640183> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2016640183 endingPage "2453" @default.
- W2016640183 startingPage "2452" @default.
- W2016640183 abstract "Disease recurrence after organ transplantation associated with graft failure is a major clinical challenge in autoimmune diseases. Primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) and autoimmune Hepatitis (AIH) are the three most common (autoimmune liver diseases) ALD for which liver transplantation (LT) is the most effective treatment option for patients with end-stage diseases. Although the 5- and 10-year survival rates of post-LT patients are remarkable (80–84% and 71–79% in PBC, 73–87% and 58–83% in PSC, 76–79% and 67–77% respectively in AIH patients), post-LT disease recurrence is not uncommon. Here, we summarize literature findings on disease recurrence of these ALD with emphasis on the incidence, risk factors and impact on long-term outcome. We noted that the incidence of disease recurrence varies between studies, which ranges from 53% to 10.9% in PBC, 8.2% to 44.7% in PSC and 7% to 42% in AIH. The variations are likely due to differences in study design, such as sample size, duration of studies and follow up time. This is further compounded by the lack of precise clinical diagnosis criteria and biomarkers of disease recurrence in these ALD, variation in post-LT treatment protocols to prevent disease recurrence and a multitude of risk factors associated with these ALD. While recurrence of PBC and AIH does not significantly impact long term outcome including overall survival, recurrent PSC patients often require another LT. Renal transplantation, like LT, is the treatment of choice in patients with end-stage lupus nephritis. While calcineurin inhibitor (CNI) and immunosuppressive drugs have improved the survival rate, post-transplant recurrence of lupus nephritis from surveillance-biopsy proven lupus nephritis range from 30% to 44%. On the other hand, recurrence of post-transplant lupus nephritis from registry survey analysis were only 1.1% to 2.4%. In general, risk factors associated with an increased frequency of post-transplant recurrence of autoimmune diseases are not clearly defined. Large scale multi-center studies are needed to further define guidelines for the diagnosis and clinical management to minimize disease recurrence and improve outcomes of post-transplant patients." @default.
- W2016640183 created "2016-06-24" @default.
- W2016640183 creator A5049766144 @default.
- W2016640183 creator A5064615611 @default.
- W2016640183 creator A5064981784 @default.
- W2016640183 creator A5071217435 @default.
- W2016640183 creator A5089682015 @default.
- W2016640183 date "2001-06-01" @default.
- W2016640183 modified "2023-10-16" @default.
- W2016640183 title "Outcome after liver transplantation for primary sclerosing cholangitis" @default.
- W2016640183 cites W2048338530 @default.
- W2016640183 cites W2060227921 @default.
- W2016640183 cites W2327697869 @default.
- W2016640183 doi "https://doi.org/10.1016/s0041-1345(01)02043-7" @default.
- W2016640183 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11406207" @default.
- W2016640183 hasPublicationYear "2001" @default.
- W2016640183 type Work @default.
- W2016640183 sameAs 2016640183 @default.
- W2016640183 citedByCount "13" @default.
- W2016640183 countsByYear W20166401832012 @default.
- W2016640183 countsByYear W20166401832017 @default.
- W2016640183 countsByYear W20166401832019 @default.
- W2016640183 countsByYear W20166401832020 @default.
- W2016640183 crossrefType "journal-article" @default.
- W2016640183 hasAuthorship W2016640183A5049766144 @default.
- W2016640183 hasAuthorship W2016640183A5064615611 @default.
- W2016640183 hasAuthorship W2016640183A5064981784 @default.
- W2016640183 hasAuthorship W2016640183A5071217435 @default.
- W2016640183 hasAuthorship W2016640183A5089682015 @default.
- W2016640183 hasConcept C120665830 @default.
- W2016640183 hasConcept C121332964 @default.
- W2016640183 hasConcept C126322002 @default.
- W2016640183 hasConcept C2777075537 @default.
- W2016640183 hasConcept C2777203481 @default.
- W2016640183 hasConcept C2779134260 @default.
- W2016640183 hasConcept C2779609443 @default.
- W2016640183 hasConcept C2779912601 @default.
- W2016640183 hasConcept C2780615123 @default.
- W2016640183 hasConcept C2911091166 @default.
- W2016640183 hasConcept C61511704 @default.
- W2016640183 hasConcept C71924100 @default.
- W2016640183 hasConcept C90924648 @default.
- W2016640183 hasConceptScore W2016640183C120665830 @default.
- W2016640183 hasConceptScore W2016640183C121332964 @default.
- W2016640183 hasConceptScore W2016640183C126322002 @default.
- W2016640183 hasConceptScore W2016640183C2777075537 @default.
- W2016640183 hasConceptScore W2016640183C2777203481 @default.
- W2016640183 hasConceptScore W2016640183C2779134260 @default.
- W2016640183 hasConceptScore W2016640183C2779609443 @default.
- W2016640183 hasConceptScore W2016640183C2779912601 @default.
- W2016640183 hasConceptScore W2016640183C2780615123 @default.
- W2016640183 hasConceptScore W2016640183C2911091166 @default.
- W2016640183 hasConceptScore W2016640183C61511704 @default.
- W2016640183 hasConceptScore W2016640183C71924100 @default.
- W2016640183 hasConceptScore W2016640183C90924648 @default.
- W2016640183 hasIssue "4" @default.
- W2016640183 hasLocation W20166401831 @default.
- W2016640183 hasLocation W20166401832 @default.
- W2016640183 hasOpenAccess W2016640183 @default.
- W2016640183 hasPrimaryLocation W20166401831 @default.
- W2016640183 hasRelatedWork W155831985 @default.
- W2016640183 hasRelatedWork W1967931951 @default.
- W2016640183 hasRelatedWork W1984016671 @default.
- W2016640183 hasRelatedWork W1998464796 @default.
- W2016640183 hasRelatedWork W2088069429 @default.
- W2016640183 hasRelatedWork W2092392577 @default.
- W2016640183 hasRelatedWork W2257083003 @default.
- W2016640183 hasRelatedWork W2411001834 @default.
- W2016640183 hasRelatedWork W4304692084 @default.
- W2016640183 hasRelatedWork W2411382025 @default.
- W2016640183 hasVolume "33" @default.
- W2016640183 isParatext "false" @default.
- W2016640183 isRetracted "false" @default.
- W2016640183 magId "2016640183" @default.
- W2016640183 workType "article" @default.