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• W2016642464 abstract "SummaryAn attempt was made to determine the means by which streptomycin inhibits erythrocyte antibodies. These studies indicate that the site of streptomycin action is the erythrocyte antibody, which is prevented from fixing to its surface-bound antigen. The streptomycin effect is not due to denaturation; the bond between antibody and antibiotic appears loose and can be separated by dialysis. The inhibitory action of streptomycin did not appear to be due to an analogue of the antigen inactivating the antibody by antibody-antigen interaction. Rather, a non-immunologic mechanism appears to be involved which possibly represents a generalized phenomenon. It is postulated that streptomycin reacts with serum globulins establishing a physical state which markedly reduces the fixation of such globulins to particulate surfaces.ResumeUne tentative a ete faite de determiner le mecanisme par lequel la streptomycine inhibe les anticorps anti-erythrocytaires. Ces recherches demontrent que le lieu d'action de la streptomycine est l'anticorps anti-erythrocytaire qui est detourne de sa fixation habituelle a la surface de l'antigene. L'effet de la streptomycine n'est pas du a une denaturation. La liaison entre l'anticorps et l'antibiotique apparait etre lâche et peut etre defaite par dialyse. L'action inhibitrice de la streptomycine ne semble pas etre due a un phenomene analogue a celui de l'interaction antigene-anticorps ou l'antigene inactive l'anticorps. Bien plutot, il doit s'agir d'un mecanisme non immunologique qui vraisemblablement represente un phenomene generalise. On pense que la streptomycine reagit avec les globulines seriques en etablissant un etat physique qui reduit d'une maniere significative la fixation de ces globulines a des surfaces bien determinees.ZusammenfassungEs wurde versucht abzuklaren, in welcher Weise Streptomycin Erythrozytenanti-kurper zu hemmen vermag. Es zeigte sich, das Streptomycin auf die Antikurper in der Weise einwirkt, das diese nicht mehr imstande sind, sich an Oberflachenantigene der Erythrozyten zu binden. Der Streptomycineffekt beruht aber nicht auf einer einfachen Denaturation. Die Bindung zwischen dem Antikurper und dem Anti-biotikum ist vielmehr so lose, das die beiden durch Dialyse voneinander getrennt werden kunnen. Die Hemmwirkung scheint nicht darauf zu beruhen, das Streptomycin wegen einer Strukturanalogie mit dem Antigen die Antigen-Antikurper-Reaktion kompetitiv hemmt. Es handelt sich wahrscheinlich um einen nicht-immunologischen Mechanismus, dem vielleicht allgemeine Bedeutung zukommt. Die Annahme scheint naheliegend, das Streptomycin die Serumglobuline in einen Zu-stand versetzt, der ihr Fixationsvermogen an korpuskularen Oberflachen erheblich beeintrachtigt." @default.
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• W2016642464 date "1964-11-12" @default.
• W2016642464 modified "2023-10-15" @default.
• W2016642464 title "The Mechanism of Streptomycin Inhibition of Erythrocyte Antibodies" @default.
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• W2016642464 doi "https://doi.org/10.1111/j.1423-0410.1964.tb04063.x" @default.
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