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• W2016643195 abstract "1. The effects of various opioid receptor agonists given directly by means of a chronically implanted cannula into the locus coeruleus (LC) on behaviour and ECoG activity, continuously analysed, and quantified as total power spectrum (0-16 Hz) and in preselected frequency bands (0-3; 3-6; 6-9; 9-12 and 12-16 Hz), were studied in rats. 2. Dermorphin (0.05, 0.5, 1, 2 and 5 pmol) and Tyr-D-Ala-Gly-N-Me-Phe-Gly-ol (DAMGO; 1, 10, 30, 100 pmol and 1 nmol), two typical mu-receptor agonists, applied unilaterally or bilaterally directly into the LC, produced a typical dose-dependent ECoG synchronization with a significant increase in total power spectrum as well as in the lower frequency bands. Dermorphin was found to be approximately 30 times more powerful than DAMGO in producing similar quantitative ECoG changes. 3. D-Ala-D-Leu-Thr-Gly-Gly-Phe-Leu (DADLE; 1, 10, 50 and 100 pmol), a selective delta-receptor agonist, micro-infused into the LC produced dose-dependent behavioural soporific effects and ECoG increase in total power spectrum as well as in 3-6, 6-9, 9-12 Hz frequency bands. In comparison to dermorphin, the ECoG power spectrum effects of DADLE were 10 fold less potent, whereas in comparison to DAMGO it was approximately 3 times more potent. A lower dose (0.1 pmol) was ineffective in changing behaviour and ECoG power spectrum. 4. The microinfusion into the LC of U 50, 488H, a selective Kappa-opioid receptor agonist, (0.25, 1, 2.5, 5 and lOpmol) produced a typical pattern characterized by a first short-lasting (3-25 min) phase of behavioural arousal and ECoG desynchronization, followed by a longer lasting (20-130min according to the dose) phase of behavioural sleep and ECoG synchronization. A lower dose (0.1 pmol) was ineffective in changing behaviour and ECoG power spectrum. 5. Dextromethorphan and ketamine, two selective agonists at sigma-receptors given into the LC (1, 5 and 1Opmol) induce behavioural arousal, increase in locomotor activity and an intense pattern of stereotypedm movements. However, by increasing the dose of ketamine (50 and lOOpmol), marked sedation, postural changes and an increase in low frequency ECoG bands, sometimes associated with high amplitude fast frequency potentials, were observed. 6. Naloxone applied directly into the LC (1 and 2 pmol 15min before) was able to prevent the behavioural and ECoG effects induced by dermorphin, DAMGO and DADLE. Higher doses of naloxone (1Opmol into the LC) were however, required to antagonize the behavioural and ECoG soporific effects induced by the Kappa-receptor agonist U 50,488H. In contrast, naloxone (1Opmol into the LC) was unable to prevent or reduce the behavioural and ECoG effects induced by subsequent administration into the same site of dextromethorphan and ketamine. 7. In conclusion, the present experiments confirm that behavioural and ECoG effects elicited following stimulation of mu-, delta-, Kappa- and sigma-opioid receptors located in the LC are quite different. Activation of ,mu-, band Kappa-receptors induced sedative effects whereas dextromethorphan and ketamine, two sigma-receptor agonists, induced behavioural arousal and ECoG desynchronization. In addition, the present results strongly support the crucial role played by opioid mechanisms, in the locus coeruleus, in the mediation of the soporific effects of drugs acting as agonists at opioid receptors." @default.
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• W2016643195 date "1990-11-01" @default.
• W2016643195 modified "2023-10-15" @default.
• W2016643195 title "Different profile of electrocortical power spectrum changes after micro-infusion into the locus coeruleus of selective agonists at various opioid receptor subtypes in rats" @default.
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• W2016643195 cites W1900414416 @default.
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• W2016643195 cites W1971474470 @default.
• W2016643195 cites W1971730406 @default.
• W2016643195 cites W1974828706 @default.
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• W2016643195 cites W1976288735 @default.
• W2016643195 cites W1980604756 @default.
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• W2016643195 cites W1997067332 @default.
• W2016643195 cites W1997924036 @default.
• W2016643195 cites W1998256759 @default.
• W2016643195 cites W1998982078 @default.
• W2016643195 cites W2001823978 @default.
• W2016643195 cites W2007074158 @default.
• W2016643195 cites W2008786172 @default.
• W2016643195 cites W2011645297 @default.
• W2016643195 cites W2012750616 @default.
• W2016643195 cites W2016275452 @default.
• W2016643195 cites W2019912398 @default.
• W2016643195 cites W2024978043 @default.
• W2016643195 cites W2026502102 @default.
• W2016643195 cites W2032843936 @default.
• W2016643195 cites W2038291091 @default.
• W2016643195 cites W2045380850 @default.
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• W2016643195 cites W2063945993 @default.
• W2016643195 cites W2073775246 @default.
• W2016643195 cites W2084159785 @default.
• W2016643195 cites W2087939380 @default.
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• W2016643195 cites W2105541592 @default.
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• W2016643195 cites W2345222972 @default.
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• W2016643195 doi "https://doi.org/10.1111/j.1476-5381.1990.tb14136.x" @default.
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