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• W2016644524 abstract "The interactions between RNA-binding proteins (RBPs) with RNA play key roles in managing some of the cells basic functions. The identification and prediction of RNA binding sites is important for understanding the RNAbinding mechanism. Computational approaches are being developed to predict RNA-binding residues based on the sequence- or structure-derived features. To achieve higher prediction accuracy, improvements on current prediction methods are necessary. We identified that the structural neighbors of RNA-binding and non-RNA-binding residues have different amino acid compositions. Combining this structure-derived feature with evolutionary (PSSM) and other structural information (secondary structure and solvent accessibility) significantly improves the predictions over existing methods. Using a multiple linear regression approach and 6-fold cross validation, our best model can achieve an overall correct rate of 87.8% and MCC of 0.47, with a specificity of 93.4%, correctly predict 52.4% of the RNA-binding residues for a dataset containing 107 non-homologous RNA-binding proteins. Compared with existing methods, including the amino acid compositions of structure neighbors lead to clearly improvement. A web server was developed for predicting RNA binding residues in a protein sequence (or structure), which is available at http://jeele.go.3322.org/RNA/. Keywords: Protein-RNA interaction, protein-RNA binding prediction, structural neighbours, multiple linear regression" @default.
• W2016644524 created "2016-06-24" @default.
• W2016644524 creator A5036086539 @default.
• W2016644524 creator A5046217910 @default.
• W2016644524 creator A5080658884 @default.
• W2016644524 date "2010-03-01" @default.
• W2016644524 modified "2023-10-17" @default.
• W2016644524 title "Improve the Prediction of RNA-Binding Residues Using Structural Neighbours" @default.
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• W2016644524 cites W1578097198 @default.
• W2016644524 cites W1601201751 @default.
• W2016644524 cites W1924414119 @default.
• W2016644524 cites W1971894358 @default.
• W2016644524 cites W1980256262 @default.
• W2016644524 cites W1981482769 @default.
• W2016644524 cites W1981532526 @default.
• W2016644524 cites W1982276763 @default.
• W2016644524 cites W1985818354 @default.
• W2016644524 cites W1987231763 @default.
• W2016644524 cites W1988907693 @default.
• W2016644524 cites W1989932358 @default.
• W2016644524 cites W1992577925 @default.
• W2016644524 cites W1992991025 @default.
• W2016644524 cites W1998331276 @default.
• W2016644524 cites W1998518361 @default.
• W2016644524 cites W2004360551 @default.
• W2016644524 cites W2005423065 @default.
• W2016644524 cites W2007922755 @default.
• W2016644524 cites W2020969907 @default.
• W2016644524 cites W2026666393 @default.
• W2016644524 cites W2027119345 @default.
• W2016644524 cites W2029580264 @default.
• W2016644524 cites W2032975481 @default.
• W2016644524 cites W2036956828 @default.
• W2016644524 cites W2044775131 @default.
• W2016644524 cites W2046691535 @default.
• W2016644524 cites W2046788335 @default.
• W2016644524 cites W2053208573 @default.
• W2016644524 cites W2062606245 @default.
• W2016644524 cites W2063122849 @default.
• W2016644524 cites W2077538414 @default.
• W2016644524 cites W2079873244 @default.
• W2016644524 cites W2080915318 @default.
• W2016644524 cites W2084309968 @default.
• W2016644524 cites W2089621332 @default.
• W2016644524 cites W2091726717 @default.
• W2016644524 cites W2091833513 @default.
• W2016644524 cites W2092676806 @default.
• W2016644524 cites W2096986143 @default.
• W2016644524 cites W2098468932 @default.
• W2016644524 cites W2099886875 @default.
• W2016644524 cites W2100147914 @default.
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• W2016644524 cites W2110896564 @default.
• W2016644524 cites W2118210812 @default.
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• W2016644524 cites W2144316442 @default.
• W2016644524 cites W2146773802 @default.
• W2016644524 cites W2147209844 @default.
• W2016644524 cites W2147918087 @default.
• W2016644524 cites W2149997286 @default.
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• W2016644524 doi "https://doi.org/10.2174/092986610790780279" @default.
• W2016644524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19508202" @default.
• W2016644524 hasPublicationYear "2010" @default.
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