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- W2016645809 abstract "Research has demonstrated that hepatitis C (HCV) genotype distribution varies geographically and demographically. This exploratory study examines HCV viremia, viral concentration, and genotype distribution among anti-HCV positive, rural Appalachian nonmedical prescription drug users. The study population was randomly selected from a pool of 200 anti-HCV positive participants in a longitudinal study. Those randomly chosen were representative of the overall pool in terms of demographics, drug use, and other risk behaviors. Participants were tested serologically for HCV RNA, viral concentration, and genotype, and interview-administered questionnaires examined behavioral and demographic characteristics. Of the 81 participants, 69% tested RNA positive, 59% of which had viral loads exceeding 800,000 IU/ml. Approximately 66% of the RNA positive sample had genotype 1a; types 2b (16%) and 3a (13%) were less common. RNA positive participants were not significantly different than RNA negative participants demographically or behaviorally. Likewise, with the exception of education, genotype 1 participants were not significantly different than those with genotype 2 or 3. The prevalence of active HCV infection highlights a need for prevention and treatment in this population. However, the predominance of genotype 1 may present challenges due to its association with decreased responsiveness to drug treatment, although the novel class of direct-acting antivirals such as telaprevir and boceprevir offer new hope in this regard. The prevalence of genotype 1 may also foreshadow heightened burden of hepatocellular carcinoma and elevated healthcare expenditures. More research is needed to characterize HCV infection and genotype in this population. J. Med. Virol. 84:1376–1387, 2012. © 2012 Wiley Periodicals, Inc." @default.
- W2016645809 created "2016-06-24" @default.
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- W2016645809 date "2012-07-18" @default.
- W2016645809 modified "2023-10-16" @default.
- W2016645809 title "Hepatitis C viremia and genotype distribution among a sample of nonmedical prescription drug users exposed to HCV in rural Appalachia" @default.
- W2016645809 cites W1509052172 @default.
- W2016645809 cites W1527786018 @default.
- W2016645809 cites W1590300762 @default.
- W2016645809 cites W1876304480 @default.
- W2016645809 cites W1964824201 @default.
- W2016645809 cites W1967376496 @default.
- W2016645809 cites W1968954289 @default.
- W2016645809 cites W1969744358 @default.
- W2016645809 cites W1970582248 @default.
- W2016645809 cites W1971610182 @default.
- W2016645809 cites W1972591384 @default.
- W2016645809 cites W1974464383 @default.
- W2016645809 cites W1974940736 @default.
- W2016645809 cites W1976687487 @default.
- W2016645809 cites W1978783755 @default.
- W2016645809 cites W1979603612 @default.
- W2016645809 cites W1981564509 @default.
- W2016645809 cites W1981812015 @default.
- W2016645809 cites W1985686008 @default.
- W2016645809 cites W1988083746 @default.
- W2016645809 cites W1989784589 @default.
- W2016645809 cites W2004506270 @default.
- W2016645809 cites W2004823945 @default.
- W2016645809 cites W2005362460 @default.
- W2016645809 cites W2010325661 @default.
- W2016645809 cites W2011235168 @default.
- W2016645809 cites W2011437704 @default.
- W2016645809 cites W2013143961 @default.
- W2016645809 cites W2013735801 @default.
- W2016645809 cites W2019611809 @default.
- W2016645809 cites W2021312918 @default.
- W2016645809 cites W2024027009 @default.
- W2016645809 cites W2024984539 @default.
- W2016645809 cites W2027442554 @default.
- W2016645809 cites W2027766932 @default.
- W2016645809 cites W2027853774 @default.
- W2016645809 cites W2030525503 @default.
- W2016645809 cites W2033259791 @default.
- W2016645809 cites W2034793309 @default.
- W2016645809 cites W2035462028 @default.
- W2016645809 cites W2036281098 @default.
- W2016645809 cites W2042191290 @default.
- W2016645809 cites W2044287878 @default.
- W2016645809 cites W2046658390 @default.
- W2016645809 cites W2048959014 @default.
- W2016645809 cites W2053763835 @default.
- W2016645809 cites W2055007705 @default.
- W2016645809 cites W2055263150 @default.
- W2016645809 cites W2058541760 @default.
- W2016645809 cites W2059194965 @default.
- W2016645809 cites W2059950149 @default.
- W2016645809 cites W2059987150 @default.
- W2016645809 cites W2060377338 @default.
- W2016645809 cites W2060940307 @default.
- W2016645809 cites W2061038424 @default.
- W2016645809 cites W2061365719 @default.
- W2016645809 cites W2064428351 @default.
- W2016645809 cites W2065686470 @default.
- W2016645809 cites W2065825827 @default.
- W2016645809 cites W2065917093 @default.
- W2016645809 cites W2066839493 @default.
- W2016645809 cites W2068790832 @default.
- W2016645809 cites W2068996625 @default.
- W2016645809 cites W2069338867 @default.
- W2016645809 cites W2071959345 @default.
- W2016645809 cites W2076873353 @default.
- W2016645809 cites W2084417858 @default.
- W2016645809 cites W2092151915 @default.
- W2016645809 cites W2093083557 @default.
- W2016645809 cites W2098887521 @default.
- W2016645809 cites W2099865291 @default.
- W2016645809 cites W2101197201 @default.
- W2016645809 cites W2101368910 @default.
- W2016645809 cites W2103207355 @default.
- W2016645809 cites W2108851656 @default.
- W2016645809 cites W2109035408 @default.
- W2016645809 cites W2111044696 @default.
- W2016645809 cites W2113450786 @default.
- W2016645809 cites W2114553504 @default.
- W2016645809 cites W2117258319 @default.
- W2016645809 cites W2118935439 @default.
- W2016645809 cites W2119168386 @default.
- W2016645809 cites W2119764771 @default.
- W2016645809 cites W2127272751 @default.
- W2016645809 cites W2127685726 @default.
- W2016645809 cites W2129581375 @default.
- W2016645809 cites W2132492420 @default.