Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016647963> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2016647963 endingPage "19" @default.
- W2016647963 startingPage "15" @default.
- W2016647963 abstract "A new model employing latex of papaya as an inflammagen has been developed for testing anti-inflammatory activity. The latex (exudate) was harvested from the unripe papaya fruit, which had been dried under vacuum. The latex was then suspended in 0.05 M sodium acetate buffer. This suspension when injected in rat hind paw produced concentration-dependent inflammation. Of the 0.25% of this suspension, 0.1 ml was found ideal for evaluating anti-inflammatory activity of test drugs. This concentration produced 70%–100% inflammation lasting for about 5 hr with a maximum effect at h 3. The test drugs employed were prednisolone, aspirin, indomethacin, phenylbutazone, ibuprofen, piroxicam, chloroquine, levamisole, and a mixture of boswellic acids. For comparison, these drugs were also tested against carrageenan-induced inflammation. All the test drugs—steroidal, aspirin, and non-aspirin-like—showed anti-inflammatory activity against latex-induced inflammation. The activity of chloroquine, levamisole, and boswellic acids was significantly more against latex as compared with that of the carrageenan model. The inflammation caused by latex may be attributed to both its hydrolytic enzymes—papain and chymopapain—and glutathione, the activator of these enzymes. These enzymes seem to act like lysosomal enzymes that are released in inflammatory disease processes which mediate inflammation by stimulating the synthesis of prostaglandins. The papaya latex-induced inflammation model appears to be a sensitive, broad-based, and relevant one likely to prove useful for discovering new and effective drugs against inflammation and rheumatoid arthritis." @default.
- W2016647963 created "2016-06-24" @default.
- W2016647963 creator A5039757889 @default.
- W2016647963 creator A5078976781 @default.
- W2016647963 creator A5080150466 @default.
- W2016647963 date "1992-08-01" @default.
- W2016647963 modified "2023-09-27" @default.
- W2016647963 title "A sensitive and relevant model for evaluating anti-inflammatory activity—papaya latex-induced rat paw inflammation" @default.
- W2016647963 cites W1783769135 @default.
- W2016647963 cites W1973284828 @default.
- W2016647963 cites W1980563273 @default.
- W2016647963 cites W1996462445 @default.
- W2016647963 cites W2008574207 @default.
- W2016647963 cites W2017622844 @default.
- W2016647963 cites W2040917958 @default.
- W2016647963 cites W2054421276 @default.
- W2016647963 cites W2067105161 @default.
- W2016647963 cites W2074618658 @default.
- W2016647963 cites W4300060781 @default.
- W2016647963 doi "https://doi.org/10.1016/1056-8719(92)90060-e" @default.
- W2016647963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1392054" @default.
- W2016647963 hasPublicationYear "1992" @default.
- W2016647963 type Work @default.
- W2016647963 sameAs 2016647963 @default.
- W2016647963 citedByCount "38" @default.
- W2016647963 countsByYear W20166479632013 @default.
- W2016647963 countsByYear W20166479632014 @default.
- W2016647963 countsByYear W20166479632015 @default.
- W2016647963 countsByYear W20166479632016 @default.
- W2016647963 countsByYear W20166479632017 @default.
- W2016647963 countsByYear W20166479632018 @default.
- W2016647963 countsByYear W20166479632019 @default.
- W2016647963 countsByYear W20166479632021 @default.
- W2016647963 countsByYear W20166479632022 @default.
- W2016647963 crossrefType "journal-article" @default.
- W2016647963 hasAuthorship W2016647963A5039757889 @default.
- W2016647963 hasAuthorship W2016647963A5078976781 @default.
- W2016647963 hasAuthorship W2016647963A5080150466 @default.
- W2016647963 hasConcept C185592680 @default.
- W2016647963 hasConcept C203014093 @default.
- W2016647963 hasConcept C2776914184 @default.
- W2016647963 hasConcept C2777628954 @default.
- W2016647963 hasConcept C2779703632 @default.
- W2016647963 hasConcept C2779944601 @default.
- W2016647963 hasConcept C2781227287 @default.
- W2016647963 hasConcept C55493867 @default.
- W2016647963 hasConcept C71924100 @default.
- W2016647963 hasConcept C98274493 @default.
- W2016647963 hasConceptScore W2016647963C185592680 @default.
- W2016647963 hasConceptScore W2016647963C203014093 @default.
- W2016647963 hasConceptScore W2016647963C2776914184 @default.
- W2016647963 hasConceptScore W2016647963C2777628954 @default.
- W2016647963 hasConceptScore W2016647963C2779703632 @default.
- W2016647963 hasConceptScore W2016647963C2779944601 @default.
- W2016647963 hasConceptScore W2016647963C2781227287 @default.
- W2016647963 hasConceptScore W2016647963C55493867 @default.
- W2016647963 hasConceptScore W2016647963C71924100 @default.
- W2016647963 hasConceptScore W2016647963C98274493 @default.
- W2016647963 hasIssue "1" @default.
- W2016647963 hasLocation W20166479631 @default.
- W2016647963 hasLocation W20166479632 @default.
- W2016647963 hasOpenAccess W2016647963 @default.
- W2016647963 hasPrimaryLocation W20166479631 @default.
- W2016647963 hasRelatedWork W1537280553 @default.
- W2016647963 hasRelatedWork W1974905307 @default.
- W2016647963 hasRelatedWork W2411118996 @default.
- W2016647963 hasRelatedWork W2417813817 @default.
- W2016647963 hasRelatedWork W2424481853 @default.
- W2016647963 hasRelatedWork W2522940298 @default.
- W2016647963 hasRelatedWork W2622609834 @default.
- W2016647963 hasRelatedWork W3148386011 @default.
- W2016647963 hasRelatedWork W32237424 @default.
- W2016647963 hasRelatedWork W91249371 @default.
- W2016647963 hasVolume "28" @default.
- W2016647963 isParatext "false" @default.
- W2016647963 isRetracted "false" @default.
- W2016647963 magId "2016647963" @default.
- W2016647963 workType "article" @default.