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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016670036> ?p ?o ?g. }

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• W2016670036 abstract "Pyruvate kinase is a rate-limiting glycolytic enzyme. The PKM1 and PKM2 isoforms result from mutually exclusive alternative splicing of the PKM pre-mRNA. PKM2 rather than PKM1 regulates the Warburg effect and tumorigenesis by poorly understood mechanisms. Emerging evidence has revealed that ERK1/2 phosphorylates PKM2, but not PKM1, leading to PIN1-dependent cis–trans isomerization and conversion of PKM2 from a tetramer to a monomer. Monomeric PKM2 translocates into the nucleus, where it functions as a histone kinase and upregulates the expression of c-Myc and cyclin D1, thereby promoting the Warburg effect and cell cycle progression, respectively. Thus, nuclear PKM2 is essential for tumorigenesis and may serve as a target for treating human cancer." @default.
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• W2016670036 date "2013-10-01" @default.
• W2016670036 modified "2023-10-15" @default.
• W2016670036 title "Nuclear PKM2 regulates the Warburg effect" @default.
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• W2016670036 doi "https://doi.org/10.4161/cc.26182" @default.
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