Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016674577> ?p ?o ?g. }
- W2016674577 endingPage "43" @default.
- W2016674577 startingPage "43" @default.
- W2016674577 abstract "Iodine-125, in the form of 5-[125I]iododeoxyuridine (I-UdR), was incorporated into the DNA of SV40 transformed Chinese hamster embryo cells. Disintegration of the 125I led to increased cell killing with increasing dose as measured by the colony-forming ability of single cells. The D37 (the dose at which 37% of the cells survive) amounts to 95 decays per cell, corresponding to 0.66 Gy. Variations in the copy number of specific DNA sequences was measured by using dispersed cell blotting with sensitive DNA hybridizations. A 13-fold amplification of the viral DNA sequences (SV40) and a twofold amplification of two cellular oncogenes of the ras-family (Ki-ras and Ha-ras) were found. Other cellular genes, like the alpha-actin gene, were not amplified, and no variation in gene copy number was detected after incubation of cells with cold I-UdR. We suggest the observed gene amplifications are induced by the densely ionizing radiation emitted by the decay of the incorporated 125I atoms." @default.
- W2016674577 created "2016-06-24" @default.
- W2016674577 creator A5016469043 @default.
- W2016674577 creator A5025881859 @default.
- W2016674577 creator A5058065559 @default.
- W2016674577 date "1986-10-01" @default.
- W2016674577 modified "2023-10-16" @default.
- W2016674577 title "Amplification of Oncogenes and Integrated SV40 Sequences in Mammalian Cells by the Decay of Incorporated Iodine-125" @default.
- W2016674577 cites W1011552192 @default.
- W2016674577 cites W1943628059 @default.
- W2016674577 cites W1966483184 @default.
- W2016674577 cites W1966607268 @default.
- W2016674577 cites W1972920532 @default.
- W2016674577 cites W1988797187 @default.
- W2016674577 cites W1993425480 @default.
- W2016674577 cites W2009181687 @default.
- W2016674577 cites W2013646631 @default.
- W2016674577 cites W2017036245 @default.
- W2016674577 cites W2017692699 @default.
- W2016674577 cites W2028519621 @default.
- W2016674577 cites W2029987769 @default.
- W2016674577 cites W2030057634 @default.
- W2016674577 cites W2035180174 @default.
- W2016674577 cites W2040720975 @default.
- W2016674577 cites W2042371773 @default.
- W2016674577 cites W2045066046 @default.
- W2016674577 cites W2048324748 @default.
- W2016674577 cites W2051144700 @default.
- W2016674577 cites W2056120923 @default.
- W2016674577 cites W2059231637 @default.
- W2016674577 cites W2059334666 @default.
- W2016674577 cites W2059903952 @default.
- W2016674577 cites W2067582588 @default.
- W2016674577 cites W2073101093 @default.
- W2016674577 cites W2080484121 @default.
- W2016674577 cites W2082749146 @default.
- W2016674577 cites W2093852705 @default.
- W2016674577 cites W2119832952 @default.
- W2016674577 cites W2137678333 @default.
- W2016674577 cites W2138135584 @default.
- W2016674577 cites W2158703239 @default.
- W2016674577 cites W2313078094 @default.
- W2016674577 cites W2410391569 @default.
- W2016674577 cites W2411584150 @default.
- W2016674577 cites W2413642407 @default.
- W2016674577 cites W2415770661 @default.
- W2016674577 cites W2417788411 @default.
- W2016674577 cites W2586156634 @default.
- W2016674577 cites W259995252 @default.
- W2016674577 doi "https://doi.org/10.2307/3576968" @default.
- W2016674577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3022326" @default.
- W2016674577 hasPublicationYear "1986" @default.
- W2016674577 type Work @default.
- W2016674577 sameAs 2016674577 @default.
- W2016674577 citedByCount "16" @default.
- W2016674577 crossrefType "journal-article" @default.
- W2016674577 hasAuthorship W2016674577A5016469043 @default.
- W2016674577 hasAuthorship W2016674577A5025881859 @default.
- W2016674577 hasAuthorship W2016674577A5058065559 @default.
- W2016674577 hasConcept C104317684 @default.
- W2016674577 hasConcept C111337013 @default.
- W2016674577 hasConcept C121332964 @default.
- W2016674577 hasConcept C133307689 @default.
- W2016674577 hasConcept C1491633281 @default.
- W2016674577 hasConcept C153911025 @default.
- W2016674577 hasConcept C18231593 @default.
- W2016674577 hasConcept C185544564 @default.
- W2016674577 hasConcept C2777755551 @default.
- W2016674577 hasConcept C54355233 @default.
- W2016674577 hasConcept C552990157 @default.
- W2016674577 hasConcept C7602840 @default.
- W2016674577 hasConcept C81885089 @default.
- W2016674577 hasConcept C86803240 @default.
- W2016674577 hasConceptScore W2016674577C104317684 @default.
- W2016674577 hasConceptScore W2016674577C111337013 @default.
- W2016674577 hasConceptScore W2016674577C121332964 @default.
- W2016674577 hasConceptScore W2016674577C133307689 @default.
- W2016674577 hasConceptScore W2016674577C1491633281 @default.
- W2016674577 hasConceptScore W2016674577C153911025 @default.
- W2016674577 hasConceptScore W2016674577C18231593 @default.
- W2016674577 hasConceptScore W2016674577C185544564 @default.
- W2016674577 hasConceptScore W2016674577C2777755551 @default.
- W2016674577 hasConceptScore W2016674577C54355233 @default.
- W2016674577 hasConceptScore W2016674577C552990157 @default.
- W2016674577 hasConceptScore W2016674577C7602840 @default.
- W2016674577 hasConceptScore W2016674577C81885089 @default.
- W2016674577 hasConceptScore W2016674577C86803240 @default.
- W2016674577 hasIssue "1" @default.
- W2016674577 hasLocation W20166745771 @default.
- W2016674577 hasLocation W20166745772 @default.
- W2016674577 hasOpenAccess W2016674577 @default.
- W2016674577 hasPrimaryLocation W20166745771 @default.
- W2016674577 hasRelatedWork W2016674577 @default.
- W2016674577 hasRelatedWork W2043199743 @default.
- W2016674577 hasRelatedWork W2070698862 @default.
- W2016674577 hasRelatedWork W2072109393 @default.
- W2016674577 hasRelatedWork W2082080217 @default.
- W2016674577 hasRelatedWork W2116925118 @default.