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• W2016675737 endingPage "414" @default.
• W2016675737 startingPage "395" @default.
• W2016675737 abstract "Astrocytes are involved in multiple brain functions in physiological conditions, participating in neuronal development, synaptic activity and homeostatic control of the extracellular environment. They also actively participate in the processes triggered by brain injuries, aimed at limiting and repairing brain damages. Purines may play a significant role in the pathophysiology of numerous acute and chronic disorders of the central nervous system (CNS). Astrocytes are the main source of cerebral purines. They release either adenine-based purines, e.g. adenosine and adenosine triphosphate, or guanine-based purines, e.g. guanosine and guanosine triphosphate, in physiological conditions and release even more of these purines in pathological conditions. Astrocytes express several receptor subtypes of P1 and P2 types for adenine-based purines. Receptors for guanine-based purines are being characterised. Specific ecto-enzymes such as nucleotidases, adenosine deaminase and, likely, purine nucleoside phosphorylase, metabolise both adenine- and guanine-based purines after release from astrocytes. This regulates the effects of nucleotides and nucleosides by reducing their interaction with specific membrane binding sites. Adenine-based nucleotides stimulate astrocyte proliferation by a P2-mediated increase in intracellular [Ca2+] and isoprenylated proteins. Adenosine also, via A2 receptors, may stimulate astrocyte proliferation, but mostly, via A1 and/or A3 receptors, inhibits astrocyte proliferation, thus controlling the excessive reactive astrogliosis triggered by P2 receptors. The activation of A1 receptors also stimulates astrocytes to produce trophic factors, such as nerve growth factor, S100beta protein and transforming growth factor beta, which contribute to protect neurons against injuries. Guanosine stimulates the output of adenine-based purines from astrocytes and in addition it directly triggers these cells to proliferate and to produce large amount of neuroprotective factors. These data indicate that adenine- and guanine-based purines released in large amounts from injured or dying cells of CNS may act as signals to initiate brain repair mechanisms widely involving astrocytes." @default.
• W2016675737 created "2016-06-24" @default.
• W2016675737 creator A5001608561 @default.
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• W2016675737 creator A5044837831 @default.
• W2016675737 creator A5091374060 @default.
• W2016675737 date "2001-05-22" @default.
• W2016675737 modified "2023-10-18" @default.
• W2016675737 title "Involvement of astrocytes in purine‐mediated reparative processes in the brain" @default.
• W2016675737 cites W11163000 @default.
• W2016675737 cites W119965119 @default.
• W2016675737 cites W131659620 @default.
• W2016675737 cites W143493625 @default.
• W2016675737 cites W1481768635 @default.
• W2016675737 cites W1506990787 @default.
• W2016675737 cites W1511707795 @default.
• W2016675737 cites W1544063520 @default.
• W2016675737 cites W1550925534 @default.
• W2016675737 cites W1556420131 @default.
• W2016675737 cites W1563309746 @default.
• W2016675737 cites W1573821584 @default.
• W2016675737 cites W1579992296 @default.
• W2016675737 cites W1590988749 @default.
• W2016675737 cites W1593177105 @default.
• W2016675737 cites W1964365720 @default.
• W2016675737 cites W1965976689 @default.
• W2016675737 cites W1967287457 @default.
• W2016675737 cites W1967471508 @default.
• W2016675737 cites W1967636582 @default.
• W2016675737 cites W1968143827 @default.
• W2016675737 cites W1969761928 @default.
• W2016675737 cites W1970424958 @default.
• W2016675737 cites W1975171053 @default.
• W2016675737 cites W1975200779 @default.
• W2016675737 cites W1977188134 @default.
• W2016675737 cites W1978074716 @default.
• W2016675737 cites W1981637709 @default.
• W2016675737 cites W1982473707 @default.
• W2016675737 cites W1984132292 @default.
• W2016675737 cites W1984454036 @default.
• W2016675737 cites W1985505219 @default.
• W2016675737 cites W1985642192 @default.
• W2016675737 cites W1986102768 @default.
• W2016675737 cites W1986918122 @default.
• W2016675737 cites W1987461945 @default.
• W2016675737 cites W1988461354 @default.
• W2016675737 cites W1989197835 @default.
• W2016675737 cites W1989813909 @default.
• W2016675737 cites W1990386835 @default.
• W2016675737 cites W1991607763 @default.
• W2016675737 cites W1992559673 @default.
• W2016675737 cites W1994245556 @default.
• W2016675737 cites W1995473185 @default.
• W2016675737 cites W1995968643 @default.
• W2016675737 cites W1996467129 @default.
• W2016675737 cites W1996845076 @default.
• W2016675737 cites W1997118739 @default.
• W2016675737 cites W1997786854 @default.
• W2016675737 cites W1998013279 @default.
• W2016675737 cites W1999175807 @default.
• W2016675737 cites W1999320859 @default.
• W2016675737 cites W2001430858 @default.
• W2016675737 cites W2002613500 @default.
• W2016675737 cites W2003293902 @default.
• W2016675737 cites W2004700698 @default.
• W2016675737 cites W2005105901 @default.
• W2016675737 cites W2006289803 @default.
• W2016675737 cites W2007582128 @default.
• W2016675737 cites W2007957507 @default.
• W2016675737 cites W2011676677 @default.
• W2016675737 cites W2012733235 @default.
• W2016675737 cites W2013679393 @default.
• W2016675737 cites W2015284998 @default.
• W2016675737 cites W2016177690 @default.
• W2016675737 cites W2017065079 @default.
• W2016675737 cites W2017243051 @default.
• W2016675737 cites W2017567167 @default.
• W2016675737 cites W2017983575 @default.
• W2016675737 cites W2018888668 @default.
• W2016675737 cites W2019519108 @default.
• W2016675737 cites W2019762265 @default.
• W2016675737 cites W2019891697 @default.
• W2016675737 cites W2020220530 @default.
• W2016675737 cites W2024003911 @default.
• W2016675737 cites W2026184579 @default.
• W2016675737 cites W2026637328 @default.
• W2016675737 cites W2026881257 @default.
• W2016675737 cites W2027126767 @default.
• W2016675737 cites W2027339399 @default.
• W2016675737 cites W2028404746 @default.
• W2016675737 cites W2029429254 @default.
• W2016675737 cites W2030031412 @default.
• W2016675737 cites W2032162782 @default.
• W2016675737 cites W2032706712 @default.
• W2016675737 cites W2034549395 @default.

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