Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016676763> ?p ?o ?g. }
- W2016676763 abstract "To assess the feasibility of manipulating human cerebrovascular resistance with adenosine, we measured cerebral blood flow (CBF) by determining the initial slope (IS) of tracer washout 20-80 s after intracarotid 133Xe injection (standard IS) during sequential 3-min intracarotid infusions of (a) saline; (b) adenosine 1.2-mg bolus followed by an infusion of 1 mg/min (bolus + infusion); (c) saline; and (d) nicardipine (0.1 mg/min). During 133Xe washout, adenosine caused a rapidly clearing compartment. Therefore, tracer washout was also analyzed 5-25 s after injection (early IS). Nicardipine (n = 8) increased both standard IS (from 39+/-12 to 53+/-16 mL 100g.min(-1); P < 0.005) and early IS (from 40+/-9 to 55+/-20 arbitrary units; P < 0.02) to a similar degree. Adenosine bolus + infusion increased early IS (from 33+/-6 to 82+/-43 arbitrary units; P < 0.02) but did not increase standard IS (from 41+/-12 to 43 +/-16 mL 100g(-1) min(-1)). Standard and early IS values were then determined before and after adenosine delivered either by infusion alone (2 mg/min for 3 min, n = 5) or bolus alone (2 mg in 1 s, n = 3). Neither standard nor early IS changed after adenosine infusion alone. Early IS increased after adenosine bolus alone. Increase in early IS, but not standard IS, suggests a transient (<30 s) increase in CBF.Intracarotid adenosine, in the 1- to 2-mg dose range, may cause a transient, but not a sustained, increase in cerebral blood flow. Intracarotid adenosine in such a dose range does not seem to be an appropriate drug for sustained manipulation of cerebrovascular resistance." @default.
- W2016676763 created "2016-06-24" @default.
- W2016676763 creator A5007302818 @default.
- W2016676763 creator A5007369226 @default.
- W2016676763 creator A5015782919 @default.
- W2016676763 creator A5019115326 @default.
- W2016676763 creator A5022345372 @default.
- W2016676763 creator A5026699335 @default.
- W2016676763 creator A5027851201 @default.
- W2016676763 creator A5032606776 @default.
- W2016676763 date "1998-12-01" @default.
- W2016676763 modified "2023-10-12" @default.
- W2016676763 title "The Feasibility of Intracarotid Adenosine for the Manipulation of Human Cerebrovascular Resistance" @default.
- W2016676763 cites W1617537169 @default.
- W2016676763 cites W1983986442 @default.
- W2016676763 cites W1990228641 @default.
- W2016676763 cites W1999022425 @default.
- W2016676763 cites W1999086038 @default.
- W2016676763 cites W2009106604 @default.
- W2016676763 cites W2011376102 @default.
- W2016676763 cites W2013439044 @default.
- W2016676763 cites W2016413171 @default.
- W2016676763 cites W2017194519 @default.
- W2016676763 cites W2025664264 @default.
- W2016676763 cites W2027478923 @default.
- W2016676763 cites W2044217422 @default.
- W2016676763 cites W2046816668 @default.
- W2016676763 cites W2047986136 @default.
- W2016676763 cites W2051173927 @default.
- W2016676763 cites W2051963291 @default.
- W2016676763 cites W2053235358 @default.
- W2016676763 cites W2060299738 @default.
- W2016676763 cites W2062529983 @default.
- W2016676763 cites W2069003116 @default.
- W2016676763 cites W2074719184 @default.
- W2016676763 cites W2074860345 @default.
- W2016676763 cites W2083619724 @default.
- W2016676763 cites W2099695922 @default.
- W2016676763 cites W2130694858 @default.
- W2016676763 cites W2150250392 @default.
- W2016676763 cites W2154154778 @default.
- W2016676763 cites W2163564594 @default.
- W2016676763 cites W2378326107 @default.
- W2016676763 cites W4229548167 @default.
- W2016676763 doi "https://doi.org/10.1097/00000539-199812000-00015" @default.
- W2016676763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9842815" @default.
- W2016676763 hasPublicationYear "1998" @default.
- W2016676763 type Work @default.
- W2016676763 sameAs 2016676763 @default.
- W2016676763 citedByCount "11" @default.
- W2016676763 countsByYear W20166767632014 @default.
- W2016676763 countsByYear W20166767632016 @default.
- W2016676763 crossrefType "journal-article" @default.
- W2016676763 hasAuthorship W2016676763A5007302818 @default.
- W2016676763 hasAuthorship W2016676763A5007369226 @default.
- W2016676763 hasAuthorship W2016676763A5015782919 @default.
- W2016676763 hasAuthorship W2016676763A5019115326 @default.
- W2016676763 hasAuthorship W2016676763A5022345372 @default.
- W2016676763 hasAuthorship W2016676763A5026699335 @default.
- W2016676763 hasAuthorship W2016676763A5027851201 @default.
- W2016676763 hasAuthorship W2016676763A5032606776 @default.
- W2016676763 hasConcept C126322002 @default.
- W2016676763 hasConcept C157767197 @default.
- W2016676763 hasConcept C178853913 @default.
- W2016676763 hasConcept C2776991684 @default.
- W2016676763 hasConcept C2777397205 @default.
- W2016676763 hasConcept C2778043224 @default.
- W2016676763 hasConcept C42219234 @default.
- W2016676763 hasConcept C43376680 @default.
- W2016676763 hasConcept C519063684 @default.
- W2016676763 hasConcept C58245268 @default.
- W2016676763 hasConcept C71839028 @default.
- W2016676763 hasConcept C71924100 @default.
- W2016676763 hasConceptScore W2016676763C126322002 @default.
- W2016676763 hasConceptScore W2016676763C157767197 @default.
- W2016676763 hasConceptScore W2016676763C178853913 @default.
- W2016676763 hasConceptScore W2016676763C2776991684 @default.
- W2016676763 hasConceptScore W2016676763C2777397205 @default.
- W2016676763 hasConceptScore W2016676763C2778043224 @default.
- W2016676763 hasConceptScore W2016676763C42219234 @default.
- W2016676763 hasConceptScore W2016676763C43376680 @default.
- W2016676763 hasConceptScore W2016676763C519063684 @default.
- W2016676763 hasConceptScore W2016676763C58245268 @default.
- W2016676763 hasConceptScore W2016676763C71839028 @default.
- W2016676763 hasConceptScore W2016676763C71924100 @default.
- W2016676763 hasLocation W20166767631 @default.
- W2016676763 hasLocation W20166767632 @default.
- W2016676763 hasOpenAccess W2016676763 @default.
- W2016676763 hasPrimaryLocation W20166767631 @default.
- W2016676763 hasRelatedWork W1992817034 @default.
- W2016676763 hasRelatedWork W2005403426 @default.
- W2016676763 hasRelatedWork W2009398655 @default.
- W2016676763 hasRelatedWork W2016676763 @default.
- W2016676763 hasRelatedWork W2043613596 @default.
- W2016676763 hasRelatedWork W2046013034 @default.
- W2016676763 hasRelatedWork W2048131422 @default.
- W2016676763 hasRelatedWork W2364272925 @default.
- W2016676763 hasRelatedWork W2386337036 @default.
- W2016676763 hasRelatedWork W3030311795 @default.
- W2016676763 isParatext "false" @default.