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• W2016682088 abstract "Hypoxic pulmonary vasoconstriction (HPV) is driven by the intrinsic response to hypoxia of pulmonary arterial smooth muscle and endothelial cells. These are representatives of a group of specialized O2-sensing cells, defined by their acute sensitivity to relatively small changes in pO2, which have evolved to modulate respiratory and circulatory function in order to maintain O2 supply within physiological limits. The aim of this article is to discuss recent investigations into the mechanism(s) of hypoxia-response coupling and, in light of these, provide a critical assessment of current working hypotheses.Upon exposure to hypoxia state-of-the-art technologies have now confirmed that mitochondrial oxidative phosphorylation is inhibited in all O2-sensing cells, including pulmonary arterial smooth muscle cells. Thereafter, evidence has been presented to indicate a role as principal effector for the 'gasotransmitters' carbon monoxide and hydrogen sulphide, reactive oxygen species or, in marked contrast, reduced cellular redox couples. Considering recent evidence in favour and against these proposals we suggest that an alternative mechanism may be key, namely the activation of adenosine monophosphate-activated protein kinase consequent to inhibition of mitochondrial oxidative phosphorylation.HPV supports ventilation-perfusion matching in the lung by diverting blood flow away from oxygen-deprived areas towards regions rich in O2. However, in diseases such as emphysema and cystic fibrosis, widespread HPV leads to hypoxic pulmonary hypertension and ultimately right heart failure. Determining the precise mechanism(s) that underpins hypoxia-response coupling will therefore advance understanding of the fundamental processes contributing to related pathophysiology and provide for improved therapeutics." @default.
• W2016682088 created "2016-06-24" @default.
• W2016682088 creator A5021541994 @default.
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• W2016682088 date "2011-02-01" @default.
• W2016682088 modified "2023-10-01" @default.
• W2016682088 title "Hypoxic pulmonary vasoconstriction: mechanisms of oxygen-sensing" @default.
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• W2016682088 cites W140960585 @default.
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• W2016682088 cites W1883147193 @default.
• W2016682088 cites W1900961504 @default.
• W2016682088 cites W1925799544 @default.
• W2016682088 cites W1946456935 @default.
• W2016682088 cites W1964320031 @default.
• W2016682088 cites W1965369357 @default.
• W2016682088 cites W1966706887 @default.
• W2016682088 cites W1967457318 @default.
• W2016682088 cites W1968885616 @default.
• W2016682088 cites W1976151623 @default.
• W2016682088 cites W1980829733 @default.
• W2016682088 cites W1983924090 @default.
• W2016682088 cites W1987981231 @default.
• W2016682088 cites W1988875133 @default.
• W2016682088 cites W1995272882 @default.
• W2016682088 cites W1997583884 @default.
• W2016682088 cites W2003831717 @default.
• W2016682088 cites W2007206583 @default.
• W2016682088 cites W2007534790 @default.
• W2016682088 cites W2011817034 @default.
• W2016682088 cites W2012268221 @default.
• W2016682088 cites W2016249305 @default.
• W2016682088 cites W2020179603 @default.
• W2016682088 cites W2027048243 @default.
• W2016682088 cites W2034185959 @default.
• W2016682088 cites W2049220790 @default.
• W2016682088 cites W2049426716 @default.
• W2016682088 cites W2053022803 @default.
• W2016682088 cites W2056872414 @default.
• W2016682088 cites W2057998788 @default.
• W2016682088 cites W2061431235 @default.
• W2016682088 cites W2067522487 @default.
• W2016682088 cites W2068027702 @default.
• W2016682088 cites W2075366948 @default.
• W2016682088 cites W2078424026 @default.
• W2016682088 cites W2078508655 @default.
• W2016682088 cites W2080627140 @default.
• W2016682088 cites W2087004550 @default.
• W2016682088 cites W2087706962 @default.
• W2016682088 cites W2088651120 @default.
• W2016682088 cites W2091589785 @default.
• W2016682088 cites W2100128214 @default.
• W2016682088 cites W2105900110 @default.
• W2016682088 cites W2110112605 @default.
• W2016682088 cites W2114263316 @default.
• W2016682088 cites W2114825009 @default.
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• W2016682088 cites W2127218310 @default.
• W2016682088 cites W2139490991 @default.
• W2016682088 cites W2140377941 @default.
• W2016682088 cites W2141174309 @default.
• W2016682088 cites W2147295203 @default.
• W2016682088 cites W2147791685 @default.
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• W2016682088 cites W2158802782 @default.
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• W2016682088 doi "https://doi.org/10.1097/aco.0b013e3283421201" @default.
• W2016682088 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3154643" @default.
• W2016682088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21157304" @default.
• W2016682088 hasPublicationYear "2011" @default.
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