Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016686594> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2016686594 endingPage "49" @default.
- W2016686594 startingPage "1" @default.
- W2016686594 abstract "Digitalis and diuretics constitute conventional therapy of congestive heart failure, but systemic vasodilators offer an innovative approach in acute and chronic heart failure of decreasing increased left ventricular systolic wall tension (ventricular afterload) by reducing aortic impedance and/or by reducing cardiac venous return. Thus, vasodilators increase cardiac output (CO) by diminishing peripheral vascular resistance (PVR) and/or decrease increased left ventricular end-diastolic pressure (LVEDP) (ventricular preload) by diminishing venous tone. Concomitantly, there is reduction of myocardial oxygen demand, thereby reliably reducing angina pectoris in coronary disease, and potentially limiting infarct size and ischemia provided systemic arterial pressure remains normal.The vasodilators produce disparate modifications of cardiac function depending upon their differing alterations of preload versus impedance: nitrates principally cause venodilation (decrease LVEDP); nitroprusside, phentolamine and prazosin produce balanced arterial and venous dilation (decrease LVEDP and increase CO) provided left ventricular filling pressure is maintained at the upper limit of normal; whereas hydralazine predominantly effects arteriolar dilation (increases CO). With depressed CO plus highly increased LVEDP and increased PVR, nitrates also induce some increase of CO by reducing PVR. Combined nitroprusside and dopamine synergistically enhance CO and decrease LVEDP. Mechanical counterpulsation aids nitroprusside in acute myocardial infarction. The 30-minute venodilator action of sublingual nitroglycerin is extended for 4 to 6 hours by cutaneous nitrogylcerin ointment, by sublingual and oral isosorbide dinitrate, and by oral pentaerythritol tetranitrate and sustained-release nitroglycerin capsules. Ambulatory oral vasodilator therapy is provided by long-acting nitrates (relieve pulmonary congestion); hydralazine (improves fatigue); prazosin alone, combined nitrate-hydralazine and combined prazosin-hydralazine (improve both dyspnea and fatigue)." @default.
- W2016686594 created "2016-06-24" @default.
- W2016686594 creator A5018832071 @default.
- W2016686594 date "1977-01-01" @default.
- W2016686594 modified "2023-10-18" @default.
- W2016686594 title "The failing heart" @default.
- W2016686594 cites W1489308694 @default.
- W2016686594 cites W1494970897 @default.
- W2016686594 cites W1506631985 @default.
- W2016686594 cites W1963748134 @default.
- W2016686594 cites W1965953785 @default.
- W2016686594 cites W1965989022 @default.
- W2016686594 cites W1999520838 @default.
- W2016686594 cites W2002854148 @default.
- W2016686594 cites W2010447275 @default.
- W2016686594 cites W2037496525 @default.
- W2016686594 cites W2054717769 @default.
- W2016686594 cites W2060517410 @default.
- W2016686594 cites W2068983688 @default.
- W2016686594 cites W2075543933 @default.
- W2016686594 cites W2079871045 @default.
- W2016686594 cites W2083847661 @default.
- W2016686594 cites W2089662149 @default.
- W2016686594 cites W2095110868 @default.
- W2016686594 cites W2157394166 @default.
- W2016686594 cites W2162268316 @default.
- W2016686594 cites W2335953854 @default.
- W2016686594 cites W2919034279 @default.
- W2016686594 doi "https://doi.org/10.1016/s0011-5029(77)80003-5" @default.
- W2016686594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/188607" @default.
- W2016686594 hasPublicationYear "1977" @default.
- W2016686594 type Work @default.
- W2016686594 sameAs 2016686594 @default.
- W2016686594 citedByCount "0" @default.
- W2016686594 crossrefType "journal-article" @default.
- W2016686594 hasAuthorship W2016686594A5018832071 @default.
- W2016686594 hasConcept C120770815 @default.
- W2016686594 hasConcept C123576724 @default.
- W2016686594 hasConcept C126322002 @default.
- W2016686594 hasConcept C164705383 @default.
- W2016686594 hasConcept C178853913 @default.
- W2016686594 hasConcept C2778198053 @default.
- W2016686594 hasConcept C2778949068 @default.
- W2016686594 hasConcept C2780521442 @default.
- W2016686594 hasConcept C42219234 @default.
- W2016686594 hasConcept C48277249 @default.
- W2016686594 hasConcept C500558357 @default.
- W2016686594 hasConcept C71924100 @default.
- W2016686594 hasConcept C84393581 @default.
- W2016686594 hasConceptScore W2016686594C120770815 @default.
- W2016686594 hasConceptScore W2016686594C123576724 @default.
- W2016686594 hasConceptScore W2016686594C126322002 @default.
- W2016686594 hasConceptScore W2016686594C164705383 @default.
- W2016686594 hasConceptScore W2016686594C178853913 @default.
- W2016686594 hasConceptScore W2016686594C2778198053 @default.
- W2016686594 hasConceptScore W2016686594C2778949068 @default.
- W2016686594 hasConceptScore W2016686594C2780521442 @default.
- W2016686594 hasConceptScore W2016686594C42219234 @default.
- W2016686594 hasConceptScore W2016686594C48277249 @default.
- W2016686594 hasConceptScore W2016686594C500558357 @default.
- W2016686594 hasConceptScore W2016686594C71924100 @default.
- W2016686594 hasConceptScore W2016686594C84393581 @default.
- W2016686594 hasIssue "4" @default.
- W2016686594 hasLocation W20166865941 @default.
- W2016686594 hasLocation W20166865942 @default.
- W2016686594 hasOpenAccess W2016686594 @default.
- W2016686594 hasPrimaryLocation W20166865941 @default.
- W2016686594 hasRelatedWork W1586178092 @default.
- W2016686594 hasRelatedWork W1978094107 @default.
- W2016686594 hasRelatedWork W2008560208 @default.
- W2016686594 hasRelatedWork W2035092627 @default.
- W2016686594 hasRelatedWork W2152013327 @default.
- W2016686594 hasRelatedWork W2169190460 @default.
- W2016686594 hasRelatedWork W2470256234 @default.
- W2016686594 hasRelatedWork W3010180656 @default.
- W2016686594 hasRelatedWork W3136611282 @default.
- W2016686594 hasRelatedWork W653878345 @default.
- W2016686594 hasVolume "23" @default.
- W2016686594 isParatext "false" @default.
- W2016686594 isRetracted "false" @default.
- W2016686594 magId "2016686594" @default.
- W2016686594 workType "article" @default.