Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016688369> ?p ?o ?g. }
- W2016688369 endingPage "1062" @default.
- W2016688369 startingPage "1046" @default.
- W2016688369 abstract "Insulin secretion from pancreatic islet beta cells is acutely regulated by a complex interplay of metabolic and electrogenic events. The electrogenic mechanism regulating insulin secretion from beta cells is commonly referred to as the ATP-sensitive K+ (KATP) channel dependent pathway. Briefly, an increase in ATP and, perhaps more importantly, a decrease in ADP stimulated by glucose metabolism depolarises the beta cell by closing KATP channels. Membrane depolarisation results in the opening of voltage-dependent Ca2+ channels, and influx of Ca2+ is the main trigger for insulin secretion. Repolarisation of pancreatic beta cell action potential is mediated by the activation of voltage-dependent K+ (Kv) channels. Various Kv channel homologues have been detected in insulin secreting cells, and recent studies have shown a role for specific Kv channels as modulators of insulin secretion. Here we review the evidence supporting a role for Kv channels in the regulation of insulin secretion and discuss the potential and the limitations for beta-cell Kv channels as therapeutic targets. Furthermore, we review recent investigations of mechanisms regulating Kv channels in beta cells, which suggest that Kv channels are active participants in the regulation of beta-cell electrical activity and insulin secretion." @default.
- W2016688369 created "2016-06-24" @default.
- W2016688369 creator A5015722444 @default.
- W2016688369 creator A5031528167 @default.
- W2016688369 date "2003-08-01" @default.
- W2016688369 modified "2023-10-16" @default.
- W2016688369 title "Voltage-dependent K + channels in pancreatic beta cells: Role, regulation and potential as therapeutic targets" @default.
- W2016688369 cites W117518344 @default.
- W2016688369 cites W12417705 @default.
- W2016688369 cites W138403972 @default.
- W2016688369 cites W1490390377 @default.
- W2016688369 cites W1492860305 @default.
- W2016688369 cites W1495232868 @default.
- W2016688369 cites W1525779234 @default.
- W2016688369 cites W1540203241 @default.
- W2016688369 cites W1542367756 @default.
- W2016688369 cites W1554110968 @default.
- W2016688369 cites W1559259886 @default.
- W2016688369 cites W1581189903 @default.
- W2016688369 cites W1585798997 @default.
- W2016688369 cites W158784179 @default.
- W2016688369 cites W1603322339 @default.
- W2016688369 cites W1646051950 @default.
- W2016688369 cites W1663253598 @default.
- W2016688369 cites W1875505059 @default.
- W2016688369 cites W1892056601 @default.
- W2016688369 cites W1947481567 @default.
- W2016688369 cites W1956230392 @default.
- W2016688369 cites W1962657470 @default.
- W2016688369 cites W1963652804 @default.
- W2016688369 cites W1963789558 @default.
- W2016688369 cites W1967307504 @default.
- W2016688369 cites W1970809926 @default.
- W2016688369 cites W1970999880 @default.
- W2016688369 cites W1975370433 @default.
- W2016688369 cites W1976480628 @default.
- W2016688369 cites W1981052367 @default.
- W2016688369 cites W1981323065 @default.
- W2016688369 cites W1982318439 @default.
- W2016688369 cites W1982650705 @default.
- W2016688369 cites W1985501043 @default.
- W2016688369 cites W1985770721 @default.
- W2016688369 cites W1986915396 @default.
- W2016688369 cites W1988505512 @default.
- W2016688369 cites W1990323937 @default.
- W2016688369 cites W1991464954 @default.
- W2016688369 cites W1992295069 @default.
- W2016688369 cites W1993860558 @default.
- W2016688369 cites W1994277301 @default.
- W2016688369 cites W1994924615 @default.
- W2016688369 cites W1996166134 @default.
- W2016688369 cites W1996736723 @default.
- W2016688369 cites W1997124286 @default.
- W2016688369 cites W1997374509 @default.
- W2016688369 cites W1997940647 @default.
- W2016688369 cites W2000129051 @default.
- W2016688369 cites W2001539169 @default.
- W2016688369 cites W2001785705 @default.
- W2016688369 cites W2003231710 @default.
- W2016688369 cites W2004052324 @default.
- W2016688369 cites W2005150634 @default.
- W2016688369 cites W2005271059 @default.
- W2016688369 cites W2005678050 @default.
- W2016688369 cites W2009697737 @default.
- W2016688369 cites W2009959265 @default.
- W2016688369 cites W2010986301 @default.
- W2016688369 cites W2012217125 @default.
- W2016688369 cites W2013655106 @default.
- W2016688369 cites W2013832366 @default.
- W2016688369 cites W2015031388 @default.
- W2016688369 cites W2015113067 @default.
- W2016688369 cites W2015648089 @default.
- W2016688369 cites W2016564945 @default.
- W2016688369 cites W2017509811 @default.
- W2016688369 cites W2017654428 @default.
- W2016688369 cites W2018585804 @default.
- W2016688369 cites W2021564846 @default.
- W2016688369 cites W2022920350 @default.
- W2016688369 cites W2024622742 @default.
- W2016688369 cites W2024885397 @default.
- W2016688369 cites W2028156214 @default.
- W2016688369 cites W2030125206 @default.
- W2016688369 cites W2030128200 @default.
- W2016688369 cites W2031650437 @default.
- W2016688369 cites W2031704980 @default.
- W2016688369 cites W2032657976 @default.
- W2016688369 cites W2035537554 @default.
- W2016688369 cites W2036252458 @default.
- W2016688369 cites W2036814080 @default.
- W2016688369 cites W2038321772 @default.
- W2016688369 cites W2039109065 @default.
- W2016688369 cites W2039463959 @default.
- W2016688369 cites W2039841202 @default.
- W2016688369 cites W2041694732 @default.
- W2016688369 cites W2045370523 @default.
- W2016688369 cites W2046799089 @default.
- W2016688369 cites W2046901610 @default.
- W2016688369 cites W2049304326 @default.