Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016691753> ?p ?o ?g. }
- W2016691753 endingPage "254" @default.
- W2016691753 startingPage "248" @default.
- W2016691753 abstract "HipA of Escherichia coli is a eukaryote-like serine-threonine kinase that inhibits cell growth and induces persistence (multidrug tolerance). Previously, it was proposed that HipA inhibits cell growth by the phosphorylation of the essential translation factor EF-Tu. Here, we provide evidence that EF-Tu is not a target of HipA. Instead, a genetic screen reveals that the overexpression of glutamyl-tRNA synthetase (GltX) suppresses the toxicity of HipA. We show that HipA phosphorylates conserved Ser(239) near the active center of GltX and inhibits aminoacylation, a unique example of an aminoacyl-tRNA synthetase being inhibited by a toxin encoded by a toxin-antitoxin locus. HipA only phosphorylates tRNA(Glu)-bound GltX, which is consistent with the earlier finding that the regulatory motif containing Ser(239) changes configuration upon tRNA binding. These results indicate that HipA mediates persistence by the generation of hungry codons at the ribosomal A site that trigger the synthesis of (p)ppGpp, a hypothesis that we verify experimentally." @default.
- W2016691753 created "2016-06-24" @default.
- W2016691753 creator A5006156306 @default.
- W2016691753 creator A5028992665 @default.
- W2016691753 creator A5070618817 @default.
- W2016691753 creator A5080636450 @default.
- W2016691753 date "2013-10-01" @default.
- W2016691753 modified "2023-10-16" @default.
- W2016691753 title "Molecular Mechanism of Bacterial Persistence by HipA" @default.
- W2016691753 cites W1578769225 @default.
- W2016691753 cites W1581855175 @default.
- W2016691753 cites W1604915411 @default.
- W2016691753 cites W1666867306 @default.
- W2016691753 cites W1976701350 @default.
- W2016691753 cites W1981529363 @default.
- W2016691753 cites W1981605774 @default.
- W2016691753 cites W1992572387 @default.
- W2016691753 cites W1996140776 @default.
- W2016691753 cites W1997808632 @default.
- W2016691753 cites W2003646873 @default.
- W2016691753 cites W2008972250 @default.
- W2016691753 cites W2011753511 @default.
- W2016691753 cites W2017165733 @default.
- W2016691753 cites W2023985059 @default.
- W2016691753 cites W2034876354 @default.
- W2016691753 cites W2055114795 @default.
- W2016691753 cites W2065808567 @default.
- W2016691753 cites W2069250280 @default.
- W2016691753 cites W2073904950 @default.
- W2016691753 cites W2076073652 @default.
- W2016691753 cites W2076809355 @default.
- W2016691753 cites W2092118306 @default.
- W2016691753 cites W2102114757 @default.
- W2016691753 cites W2103650497 @default.
- W2016691753 cites W2108336065 @default.
- W2016691753 cites W2115578640 @default.
- W2016691753 cites W2121315499 @default.
- W2016691753 cites W2124562476 @default.
- W2016691753 cites W2127240867 @default.
- W2016691753 cites W2130825211 @default.
- W2016691753 cites W2135133274 @default.
- W2016691753 cites W2145676608 @default.
- W2016691753 cites W2147189708 @default.
- W2016691753 cites W2147638815 @default.
- W2016691753 cites W2148323109 @default.
- W2016691753 cites W2153148799 @default.
- W2016691753 cites W2170812406 @default.
- W2016691753 cites W2171392588 @default.
- W2016691753 cites W2614366042 @default.
- W2016691753 cites W4213353716 @default.
- W2016691753 doi "https://doi.org/10.1016/j.molcel.2013.08.045" @default.
- W2016691753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24095282" @default.
- W2016691753 hasPublicationYear "2013" @default.
- W2016691753 type Work @default.
- W2016691753 sameAs 2016691753 @default.
- W2016691753 citedByCount "295" @default.
- W2016691753 countsByYear W20166917532013 @default.
- W2016691753 countsByYear W20166917532014 @default.
- W2016691753 countsByYear W20166917532015 @default.
- W2016691753 countsByYear W20166917532016 @default.
- W2016691753 countsByYear W20166917532017 @default.
- W2016691753 countsByYear W20166917532018 @default.
- W2016691753 countsByYear W20166917532019 @default.
- W2016691753 countsByYear W20166917532020 @default.
- W2016691753 countsByYear W20166917532021 @default.
- W2016691753 countsByYear W20166917532022 @default.
- W2016691753 countsByYear W20166917532023 @default.
- W2016691753 crossrefType "journal-article" @default.
- W2016691753 hasAuthorship W2016691753A5006156306 @default.
- W2016691753 hasAuthorship W2016691753A5028992665 @default.
- W2016691753 hasAuthorship W2016691753A5070618817 @default.
- W2016691753 hasAuthorship W2016691753A5080636450 @default.
- W2016691753 hasBestOaLocation W20166917531 @default.
- W2016691753 hasConcept C104317684 @default.
- W2016691753 hasConcept C11960822 @default.
- W2016691753 hasConcept C153957851 @default.
- W2016691753 hasConcept C2776414213 @default.
- W2016691753 hasConcept C547475151 @default.
- W2016691753 hasConcept C55493867 @default.
- W2016691753 hasConcept C67705224 @default.
- W2016691753 hasConcept C86803240 @default.
- W2016691753 hasConcept C95444343 @default.
- W2016691753 hasConceptScore W2016691753C104317684 @default.
- W2016691753 hasConceptScore W2016691753C11960822 @default.
- W2016691753 hasConceptScore W2016691753C153957851 @default.
- W2016691753 hasConceptScore W2016691753C2776414213 @default.
- W2016691753 hasConceptScore W2016691753C547475151 @default.
- W2016691753 hasConceptScore W2016691753C55493867 @default.
- W2016691753 hasConceptScore W2016691753C67705224 @default.
- W2016691753 hasConceptScore W2016691753C86803240 @default.
- W2016691753 hasConceptScore W2016691753C95444343 @default.
- W2016691753 hasIssue "2" @default.
- W2016691753 hasLocation W20166917531 @default.
- W2016691753 hasLocation W20166917532 @default.
- W2016691753 hasOpenAccess W2016691753 @default.
- W2016691753 hasPrimaryLocation W20166917531 @default.
- W2016691753 hasRelatedWork W1483292430 @default.
- W2016691753 hasRelatedWork W1953044259 @default.