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- W2016703298 abstract "Variability in arterial pressure and cerebral blood flow has traditionally been interpreted as a marker of cardiovascular decompensation, and has been associated with negative clinical outcomes across varying time scales, from impending orthostatic syncope to an increased risk of stroke. Emerging evidence, however, suggests that increased hemodynamic variability may, in fact, be protective in the face of acute challenges to perfusion, including significant central hypovolemia and hypotension (including hemorrhage), and during cardiac bypass surgery. We present the dichotomous views on the role of hemodynamic variability on clinical outcome, including the physiological mechanisms underlying these patterns, and the potential impact of increased and decreased variability on cerebral perfusion and oxygenation. We suggest that reconciliation of these two apparently discrepant views may lie in the time scale of hemodynamic variability; short time scale variability appears to be cerebroprotective, while mid to longer term fluctuations are associated with primary and secondary end-organ dysfunction." @default.
- W2016703298 created "2016-06-24" @default.
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- W2016703298 date "2014-05-01" @default.
- W2016703298 modified "2023-09-26" @default.
- W2016703298 title "Blood pressure and cerebral blood flow oscillations: Friend or foe?" @default.
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- W2016703298 doi "https://doi.org/10.1109/esgco.2014.6847578" @default.
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