FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016708369> ?p ?o ?g. }

• W2016708369 endingPage "329" @default.
• W2016708369 startingPage "325" @default.
• W2016708369 abstract "Intensity-modulated radiotherapy (IMRT) plays an important role in cancer radiotherapy. For some patients being treated with IMRT, the extremely low tolerances of critical organs (such as lens, ovaries, and testicles) cannot be met during treatment planning. The aim of this article is to introduce a new planning method to overcome that problem. In current planning practice, jaw positions are automatically set to cover all target volumes by the planning system (e.g., Pinnacle3 system). Because of such settings, critical organs may be fully blocked by the multileaf collimator (MLC), but they still sit in the field that is shaped by collimator jaws. These critical organs receive doses from the transmission and leakage of MLC leaves. We manually fixed jaw positions to block them to further reduce such doses. This method has been used for different treatment sites in our clinic, and it was thoroughly evaluated in patients with radical hysterectomy plus ovarian transposition after surgery. For each patient, 2 treatment plans were designed with the same optimization parameters: the original plan with automatically chosen jaw positions (called O-plan) and the plan with fixed-jaw positions (named F-plan). In the F-plan, the jaws were manually fixed to block the ovaries. For target coverage, the mean conformity index (CI) of the F-plan (1.28 ± 0.02) was remarkably lower than that of the O-plan (1.53 ± 0.09) (p < 0.05). The F-plan and the O-plan performed similarly in target dose homogeneity. Meanwhile, for the critical organ sparing, the mean dose of both ovaries were much lower in the F-plan than that in the O-plan (p < 0.05). The V20, V30, and V40 of bladder were also lower in the F-plan (93.57 ± 1.98, 73.99 ± 5.76, and 42.33 ± 3.7, respectively) than those in the O-plan (97.98 ± 1.11, 85.07 ± 4.04, and 49.71 ± 3.63, respectively) (p < 0.05). The maximum dose to the spinal cord planning organ at risk (OAR) volume (PRV) in the O-plan (3940.24 ± 102.8) was higher than that in the F-plan (3628.18 ± 131.45) with significant differences (p < 0.01). For other OARs, there were no significant differences in doses between these 2 plans except that the high-dose regions of the rectum were higher for V40 in the O-plan than that in the F-plan (p < 0.01). But the monitor units (MUs) in the F-plan were 1.4 times as much as that in the O-plan. Thus the treatment time could be longer by using the F-plan. As it results in more MUs in spite of better plan quality, it is recommended to be used only in situations in which clinical requirements to critical organs cannot be met with the regular method." @default.
• W2016708369 created "2016-06-24" @default.
• W2016708369 creator A5013220718 @default.
• W2016708369 creator A5023536809 @default.
• W2016708369 creator A5032015275 @default.
• W2016708369 creator A5045621966 @default.
• W2016708369 date "2014-01-01" @default.
• W2016708369 modified "2023-09-26" @default.
• W2016708369 title "A fixed-jaw method to protect critical organs during intensity-modulated radiotherapy" @default.
• W2016708369 cites W1497439354 @default.
• W2016708369 cites W1934578301 @default.
• W2016708369 cites W1990854333 @default.
• W2016708369 cites W2026669226 @default.
• W2016708369 cites W2063605197 @default.
• W2016708369 cites W2100371624 @default.
• W2016708369 cites W2196845277 @default.
• W2016708369 doi "https://doi.org/10.1016/j.meddos.2014.05.006" @default.
• W2016708369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25087082" @default.
• W2016708369 hasPublicationYear "2014" @default.
• W2016708369 type Work @default.
• W2016708369 sameAs 2016708369 @default.
• W2016708369 citedByCount "10" @default.
• W2016708369 countsByYear W20167083692016 @default.
• W2016708369 countsByYear W20167083692017 @default.
• W2016708369 countsByYear W20167083692018 @default.
• W2016708369 countsByYear W20167083692019 @default.
• W2016708369 countsByYear W20167083692021 @default.
• W2016708369 countsByYear W20167083692023 @default.
• W2016708369 crossrefType "journal-article" @default.
• W2016708369 hasAuthorship W2016708369A5013220718 @default.
• W2016708369 hasAuthorship W2016708369A5023536809 @default.
• W2016708369 hasAuthorship W2016708369A5032015275 @default.
• W2016708369 hasAuthorship W2016708369A5045621966 @default.
• W2016708369 hasConcept C120665830 @default.
• W2016708369 hasConcept C121332964 @default.
• W2016708369 hasConcept C126838900 @default.
• W2016708369 hasConcept C161471255 @default.
• W2016708369 hasConcept C19527891 @default.
• W2016708369 hasConcept C201645570 @default.
• W2016708369 hasConcept C2779200277 @default.
• W2016708369 hasConcept C2989005 @default.
• W2016708369 hasConcept C41008148 @default.
• W2016708369 hasConcept C509974204 @default.
• W2016708369 hasConcept C71924100 @default.
• W2016708369 hasConceptScore W2016708369C120665830 @default.
• W2016708369 hasConceptScore W2016708369C121332964 @default.
• W2016708369 hasConceptScore W2016708369C126838900 @default.
• W2016708369 hasConceptScore W2016708369C161471255 @default.
• W2016708369 hasConceptScore W2016708369C19527891 @default.
• W2016708369 hasConceptScore W2016708369C201645570 @default.
• W2016708369 hasConceptScore W2016708369C2779200277 @default.
• W2016708369 hasConceptScore W2016708369C2989005 @default.
• W2016708369 hasConceptScore W2016708369C41008148 @default.
• W2016708369 hasConceptScore W2016708369C509974204 @default.
• W2016708369 hasConceptScore W2016708369C71924100 @default.
• W2016708369 hasIssue "4" @default.
• W2016708369 hasLocation W20167083691 @default.
• W2016708369 hasLocation W20167083692 @default.
• W2016708369 hasOpenAccess W2016708369 @default.
• W2016708369 hasPrimaryLocation W20167083691 @default.
• W2016708369 hasRelatedWork W1581093932 @default.
• W2016708369 hasRelatedWork W1977472174 @default.
• W2016708369 hasRelatedWork W1995822876 @default.
• W2016708369 hasRelatedWork W1997473995 @default.
• W2016708369 hasRelatedWork W2008355295 @default.
• W2016708369 hasRelatedWork W2035168770 @default.
• W2016708369 hasRelatedWork W2083433357 @default.
• W2016708369 hasRelatedWork W2109490458 @default.
• W2016708369 hasRelatedWork W2148023536 @default.
• W2016708369 hasRelatedWork W2409321793 @default.
• W2016708369 hasVolume "39" @default.
• W2016708369 isParatext "false" @default.
• W2016708369 isRetracted "false" @default.
• W2016708369 magId "2016708369" @default.
• W2016708369 workType "article" @default.