FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016709703> ?p ?o ?g. }

• W2016709703 endingPage "116" @default.
• W2016709703 startingPage "110" @default.
• W2016709703 abstract "We investigated the effects of synthetic cannabinoids, WIN55,212-2 and HU210, on LPS-injected rat substantia nigra in vivo. Intranigral injection of LPS resulted in a significant loss of nigral dopaminergic (DA) neurons, as determined by Nissl staining and TH immunohistochemistry. LPS-induced neurotoxicity was accompanied by microglial activation, as demonstrated by OX-42 immunohistochemistry. In parallel, Western blot analysis, ELISA assay and hydroethidine histochemistry revealed activation of NADPH oxidase, as demonstrated by increased translocation of the cytosolic proteins p47(phox) and p67(phox), generation of reactive oxygen species (ROS) and increased level of proinflammatory cytokines (TNF-α and IL-1β), where degeneration of nigral DA neurons was evident. Interestingly, WIN55,212-2 and HU210 increased the survival of nigral DA neurons at 7days post-LPS treatment. Consistent with these results, cannabinoids inhibited activation of NADPH oxidase, ROS production and production of proinflammatory cytokines in the rat SN. The present data suggest that cannabinoids may be beneficial for the treatment of neurodegenerative diseases, such as PD, that are associated with microglial activation." @default.
• W2016709703 created "2016-06-24" @default.
• W2016709703 creator A5013526503 @default.
• W2016709703 creator A5036919534 @default.
• W2016709703 creator A5055549980 @default.
• W2016709703 creator A5060641907 @default.
• W2016709703 creator A5068286462 @default.
• W2016709703 date "2012-04-01" @default.
• W2016709703 modified "2023-09-26" @default.
• W2016709703 title "Cannabinoids prevent lipopolysaccharide-induced neurodegeneration in the rat substantia nigra in vivo through inhibition of microglial activation and NADPH oxidase" @default.
• W2016709703 cites W1500418512 @default.
• W2016709703 cites W1577637371 @default.
• W2016709703 cites W1580441010 @default.
• W2016709703 cites W1604823664 @default.
• W2016709703 cites W1971701992 @default.
• W2016709703 cites W1975774284 @default.
• W2016709703 cites W1981356063 @default.
• W2016709703 cites W1982731273 @default.
• W2016709703 cites W1989073099 @default.
• W2016709703 cites W2004349171 @default.
• W2016709703 cites W2008010082 @default.
• W2016709703 cites W2028794471 @default.
• W2016709703 cites W2035943162 @default.
• W2016709703 cites W2039190334 @default.
• W2016709703 cites W2047180193 @default.
• W2016709703 cites W2054333837 @default.
• W2016709703 cites W2054817857 @default.
• W2016709703 cites W2066039419 @default.
• W2016709703 cites W2066762007 @default.
• W2016709703 cites W2073524128 @default.
• W2016709703 cites W2079080506 @default.
• W2016709703 cites W2085741941 @default.
• W2016709703 cites W2096901938 @default.
• W2016709703 cites W2104142184 @default.
• W2016709703 cites W2111096047 @default.
• W2016709703 cites W2147313422 @default.
• W2016709703 cites W2163150813 @default.
• W2016709703 doi "https://doi.org/10.1016/j.brainres.2012.02.058" @default.
• W2016709703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22436849" @default.
• W2016709703 hasPublicationYear "2012" @default.
• W2016709703 type Work @default.
• W2016709703 sameAs 2016709703 @default.
• W2016709703 citedByCount "54" @default.
• W2016709703 countsByYear W20167097032012 @default.
• W2016709703 countsByYear W20167097032013 @default.
• W2016709703 countsByYear W20167097032014 @default.
• W2016709703 countsByYear W20167097032015 @default.
• W2016709703 countsByYear W20167097032016 @default.
• W2016709703 countsByYear W20167097032017 @default.
• W2016709703 countsByYear W20167097032018 @default.
• W2016709703 countsByYear W20167097032019 @default.
• W2016709703 countsByYear W20167097032020 @default.
• W2016709703 countsByYear W20167097032021 @default.
• W2016709703 countsByYear W20167097032022 @default.
• W2016709703 countsByYear W20167097032023 @default.
• W2016709703 crossrefType "journal-article" @default.
• W2016709703 hasAuthorship W2016709703A5013526503 @default.
• W2016709703 hasAuthorship W2016709703A5036919534 @default.
• W2016709703 hasAuthorship W2016709703A5055549980 @default.
• W2016709703 hasAuthorship W2016709703A5060641907 @default.
• W2016709703 hasAuthorship W2016709703A5068286462 @default.
• W2016709703 hasConcept C126322002 @default.
• W2016709703 hasConcept C134018914 @default.
• W2016709703 hasConcept C137183658 @default.
• W2016709703 hasConcept C150903083 @default.
• W2016709703 hasConcept C169760540 @default.
• W2016709703 hasConcept C185592680 @default.
• W2016709703 hasConcept C207001950 @default.
• W2016709703 hasConcept C2776151105 @default.
• W2016709703 hasConcept C2776914184 @default.
• W2016709703 hasConcept C2776925932 @default.
• W2016709703 hasConcept C2778754761 @default.
• W2016709703 hasConcept C2779134260 @default.
• W2016709703 hasConcept C2779719074 @default.
• W2016709703 hasConcept C2779830541 @default.
• W2016709703 hasConcept C2780938664 @default.
• W2016709703 hasConcept C513476851 @default.
• W2016709703 hasConcept C55493867 @default.
• W2016709703 hasConcept C71924100 @default.
• W2016709703 hasConcept C86803240 @default.
• W2016709703 hasConcept C98274493 @default.
• W2016709703 hasConceptScore W2016709703C126322002 @default.
• W2016709703 hasConceptScore W2016709703C134018914 @default.
• W2016709703 hasConceptScore W2016709703C137183658 @default.
• W2016709703 hasConceptScore W2016709703C150903083 @default.
• W2016709703 hasConceptScore W2016709703C169760540 @default.
• W2016709703 hasConceptScore W2016709703C185592680 @default.
• W2016709703 hasConceptScore W2016709703C207001950 @default.
• W2016709703 hasConceptScore W2016709703C2776151105 @default.
• W2016709703 hasConceptScore W2016709703C2776914184 @default.
• W2016709703 hasConceptScore W2016709703C2776925932 @default.
• W2016709703 hasConceptScore W2016709703C2778754761 @default.
• W2016709703 hasConceptScore W2016709703C2779134260 @default.
• W2016709703 hasConceptScore W2016709703C2779719074 @default.
• W2016709703 hasConceptScore W2016709703C2779830541 @default.
• W2016709703 hasConceptScore W2016709703C2780938664 @default.
• W2016709703 hasConceptScore W2016709703C513476851 @default.
• W2016709703 hasConceptScore W2016709703C55493867 @default.

• next