Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016718423> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2016718423 endingPage "78" @default.
- W2016718423 startingPage "66" @default.
- W2016718423 abstract "Receptor-based drug design is predicated on the knowledge of the structure of a target receptor and the principles of molecule recognition. The objective is to produce a wide diversity of structures that are sterically and electrostatically complementary to a specified receptor site. Many drug—receptor interactions are controlled by a few key receptor groups. This observation leads to a design approach in which one focuses on chemical fragments that putatively interact with the key receptor groups. There then remains the difficult task of joining the fragments into molecular structures that match the spatial patterns of recognition forces in the receptor site. In this paper, we describe a new modeling program, BUILDER, that combines database searching techniques and structure generation algorithms within an interactive graphics modeling environment (MidasPlus). A novel tool for process communication (delegate) is introduced and examples of its use are given. To demonstrate the functionality of the package and its ability to produce novel structures, we examine the active site of HIV-1 protease." @default.
- W2016718423 created "2016-06-24" @default.
- W2016718423 creator A5015356572 @default.
- W2016718423 creator A5016702736 @default.
- W2016718423 creator A5033903761 @default.
- W2016718423 creator A5053671404 @default.
- W2016718423 creator A5059465522 @default.
- W2016718423 creator A5086093811 @default.
- W2016718423 date "1992-06-01" @default.
- W2016718423 modified "2023-09-26" @default.
- W2016718423 title "Automated site-directed drug design using molecular lattices" @default.
- W2016718423 cites W1568609060 @default.
- W2016718423 cites W1963716251 @default.
- W2016718423 cites W1966543998 @default.
- W2016718423 cites W1979046104 @default.
- W2016718423 cites W1986671430 @default.
- W2016718423 cites W1994583921 @default.
- W2016718423 cites W2007618885 @default.
- W2016718423 cites W2013779200 @default.
- W2016718423 cites W2020081273 @default.
- W2016718423 cites W2032402250 @default.
- W2016718423 cites W2048045849 @default.
- W2016718423 cites W2050654179 @default.
- W2016718423 cites W2067455153 @default.
- W2016718423 cites W2074267393 @default.
- W2016718423 cites W2080653934 @default.
- W2016718423 cites W2082040139 @default.
- W2016718423 cites W2084891561 @default.
- W2016718423 cites W2087876594 @default.
- W2016718423 cites W2138199172 @default.
- W2016718423 cites W2161117347 @default.
- W2016718423 cites W2170088433 @default.
- W2016718423 doi "https://doi.org/10.1016/0263-7855(92)80059-m" @default.
- W2016718423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1637751" @default.
- W2016718423 hasPublicationYear "1992" @default.
- W2016718423 type Work @default.
- W2016718423 sameAs 2016718423 @default.
- W2016718423 citedByCount "94" @default.
- W2016718423 countsByYear W20167184232012 @default.
- W2016718423 countsByYear W20167184232013 @default.
- W2016718423 countsByYear W20167184232016 @default.
- W2016718423 countsByYear W20167184232017 @default.
- W2016718423 countsByYear W20167184232018 @default.
- W2016718423 countsByYear W20167184232022 @default.
- W2016718423 countsByYear W20167184232023 @default.
- W2016718423 crossrefType "journal-article" @default.
- W2016718423 hasAuthorship W2016718423A5015356572 @default.
- W2016718423 hasAuthorship W2016718423A5016702736 @default.
- W2016718423 hasAuthorship W2016718423A5033903761 @default.
- W2016718423 hasAuthorship W2016718423A5053671404 @default.
- W2016718423 hasAuthorship W2016718423A5059465522 @default.
- W2016718423 hasAuthorship W2016718423A5086093811 @default.
- W2016718423 hasConcept C121684516 @default.
- W2016718423 hasConcept C126766683 @default.
- W2016718423 hasConcept C143273055 @default.
- W2016718423 hasConcept C154945302 @default.
- W2016718423 hasConcept C199360897 @default.
- W2016718423 hasConcept C21442007 @default.
- W2016718423 hasConcept C26517878 @default.
- W2016718423 hasConcept C38652104 @default.
- W2016718423 hasConcept C41008148 @default.
- W2016718423 hasConcept C70721500 @default.
- W2016718423 hasConcept C77660652 @default.
- W2016718423 hasConcept C86803240 @default.
- W2016718423 hasConceptScore W2016718423C121684516 @default.
- W2016718423 hasConceptScore W2016718423C126766683 @default.
- W2016718423 hasConceptScore W2016718423C143273055 @default.
- W2016718423 hasConceptScore W2016718423C154945302 @default.
- W2016718423 hasConceptScore W2016718423C199360897 @default.
- W2016718423 hasConceptScore W2016718423C21442007 @default.
- W2016718423 hasConceptScore W2016718423C26517878 @default.
- W2016718423 hasConceptScore W2016718423C38652104 @default.
- W2016718423 hasConceptScore W2016718423C41008148 @default.
- W2016718423 hasConceptScore W2016718423C70721500 @default.
- W2016718423 hasConceptScore W2016718423C77660652 @default.
- W2016718423 hasConceptScore W2016718423C86803240 @default.
- W2016718423 hasIssue "2" @default.
- W2016718423 hasLocation W20167184231 @default.
- W2016718423 hasLocation W20167184232 @default.
- W2016718423 hasOpenAccess W2016718423 @default.
- W2016718423 hasPrimaryLocation W20167184231 @default.
- W2016718423 hasRelatedWork W1666949226 @default.
- W2016718423 hasRelatedWork W1965462237 @default.
- W2016718423 hasRelatedWork W1996643056 @default.
- W2016718423 hasRelatedWork W2002869446 @default.
- W2016718423 hasRelatedWork W2032402250 @default.
- W2016718423 hasRelatedWork W2040471561 @default.
- W2016718423 hasRelatedWork W2041985731 @default.
- W2016718423 hasRelatedWork W2051676847 @default.
- W2016718423 hasRelatedWork W2105916282 @default.
- W2016718423 hasRelatedWork W2412625894 @default.
- W2016718423 hasVolume "10" @default.
- W2016718423 isParatext "false" @default.
- W2016718423 isRetracted "false" @default.
- W2016718423 magId "2016718423" @default.
- W2016718423 workType "article" @default.