FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016719248> ?p ?o ?g. }

• W2016719248 endingPage "e0124112" @default.
• W2016719248 startingPage "e0124112" @default.
• W2016719248 abstract "In asymptomatic Marfan syndrome (MFS) patients we evaluated the relationship between the types of fibrillin-1 (FBN1) gene mutation and possible altered left ventricular (LV) function as assessed by three-dimensional speckle tracking echocardiography (3D-STE).Forty-five MFS patients (mean age 24 ± 15 years) and 40 age-matched healthy controls were studied. Genetic evaluation for the FBN1 gene was carried on 32 MFS patients. Gene mutation (n = 15, 47%) was classified as mild when the mutation resulted in nearly normally functioning protein, while mutations resulting in abnormally function protein were considered to be severe (n = 17, 53%). All patients and controls underwent 3D-STE for evaluation of LV function by an echocardiographer blinded to the results of the genetic testing. Compared to controls, MFS patients had significantly lower 3D-STE derived LV ejection fraction (EF, 57.43 ± 7.51 vs. 62.69 ± 4.76%, p = 0.0001), global LV longitudinal strain (LS, 14.85 ± 2.89 vs. 17.90 ± 2.01%, p = 0.0001), global LV circumferential strain (CS, 13.93 ± 2.81 vs. 16.82 ± 2.17%, p = 0.0001) and global LV area strain (AS, 25.76 ± 4.43 vs. 30.51 ± 2.61%, p = 0.0001). Apart from the global LV LS all these parameters were significantly lower in patients with severe gene mutation than in those with mild mutation (p < 0.05). In the multivariate linear regression analysis only the type of mutation had a significant influence on the 3D-STE derived LVEF (p = 0.017), global CS (p = 0.005) and global AS (p = 0.03).In asymptomatic MFS patients latent LV dysfunction can be detected using 3D STE. The LV dysfunction is mainly related to the severity of gene mutation, suggesting possible primary cardiomyopathy in MFS patients." @default.
• W2016719248 created "2016-06-24" @default.
• W2016719248 creator A5003614563 @default.
• W2016719248 creator A5006770320 @default.
• W2016719248 creator A5020207419 @default.
• W2016719248 creator A5034116008 @default.
• W2016719248 creator A5072361777 @default.
• W2016719248 creator A5077685644 @default.
• W2016719248 creator A5079529666 @default.
• W2016719248 creator A5083694688 @default.
• W2016719248 date "2015-04-22" @default.
• W2016719248 modified "2023-10-16" @default.
• W2016719248 title "Left Ventricular Systolic Dysfunction in Asymptomatic Marfan Syndrome Patients Is Related to the Severity of Gene Mutation: Insights from the Novel Three Dimensional Speckle Tracking Echocardiography" @default.
• W2016719248 cites W1637371903 @default.
• W2016719248 cites W1792987517 @default.
• W2016719248 cites W1974924746 @default.
• W2016719248 cites W1991946883 @default.
• W2016719248 cites W1992692484 @default.
• W2016719248 cites W2001102891 @default.
• W2016719248 cites W2010011058 @default.
• W2016719248 cites W2013085306 @default.
• W2016719248 cites W2017376285 @default.
• W2016719248 cites W2030217247 @default.
• W2016719248 cites W2034598601 @default.
• W2016719248 cites W2036727167 @default.
• W2016719248 cites W2041863273 @default.
• W2016719248 cites W2042164655 @default.
• W2016719248 cites W2054987328 @default.
• W2016719248 cites W2056254659 @default.
• W2016719248 cites W2056334575 @default.
• W2016719248 cites W2060410445 @default.
• W2016719248 cites W2072302002 @default.
• W2016719248 cites W2081737308 @default.
• W2016719248 cites W2090828980 @default.
• W2016719248 cites W2107902443 @default.
• W2016719248 cites W2109682533 @default.
• W2016719248 cites W2112535798 @default.
• W2016719248 cites W2117410048 @default.
• W2016719248 cites W2122473579 @default.
• W2016719248 cites W2122588714 @default.
• W2016719248 cites W2127386115 @default.
• W2016719248 cites W2128697129 @default.
• W2016719248 cites W2129797538 @default.
• W2016719248 cites W2131202416 @default.
• W2016719248 cites W2136092360 @default.
• W2016719248 cites W2146816193 @default.
• W2016719248 cites W2146979392 @default.
• W2016719248 cites W2161310326 @default.
• W2016719248 cites W2165484695 @default.
• W2016719248 cites W2170121771 @default.
• W2016719248 cites W2171820373 @default.
• W2016719248 cites W2186310428 @default.
• W2016719248 cites W2401409602 @default.
• W2016719248 cites W2410287569 @default.
• W2016719248 cites W2523082125 @default.
• W2016719248 doi "https://doi.org/10.1371/journal.pone.0124112" @default.
• W2016719248 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4406686" @default.
• W2016719248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25901601" @default.
• W2016719248 hasPublicationYear "2015" @default.
• W2016719248 type Work @default.
• W2016719248 sameAs 2016719248 @default.
• W2016719248 citedByCount "15" @default.
• W2016719248 countsByYear W20167192482016 @default.
• W2016719248 countsByYear W20167192482017 @default.
• W2016719248 countsByYear W20167192482019 @default.
• W2016719248 countsByYear W20167192482020 @default.
• W2016719248 countsByYear W20167192482021 @default.
• W2016719248 countsByYear W20167192482022 @default.
• W2016719248 countsByYear W20167192482023 @default.
• W2016719248 crossrefType "journal-article" @default.
• W2016719248 hasAuthorship W2016719248A5003614563 @default.
• W2016719248 hasAuthorship W2016719248A5006770320 @default.
• W2016719248 hasAuthorship W2016719248A5020207419 @default.
• W2016719248 hasAuthorship W2016719248A5034116008 @default.
• W2016719248 hasAuthorship W2016719248A5072361777 @default.
• W2016719248 hasAuthorship W2016719248A5077685644 @default.
• W2016719248 hasAuthorship W2016719248A5079529666 @default.
• W2016719248 hasAuthorship W2016719248A5083694688 @default.
• W2016719248 hasBestOaLocation W20167192481 @default.
• W2016719248 hasConcept C104317684 @default.
• W2016719248 hasConcept C126322002 @default.
• W2016719248 hasConcept C164705383 @default.
• W2016719248 hasConcept C2777910003 @default.
• W2016719248 hasConcept C2778198053 @default.
• W2016719248 hasConcept C2778296771 @default.
• W2016719248 hasConcept C2780561598 @default.
• W2016719248 hasConcept C2994225774 @default.
• W2016719248 hasConcept C501734568 @default.
• W2016719248 hasConcept C54355233 @default.
• W2016719248 hasConcept C71924100 @default.
• W2016719248 hasConcept C78085059 @default.
• W2016719248 hasConcept C86803240 @default.
• W2016719248 hasConceptScore W2016719248C104317684 @default.
• W2016719248 hasConceptScore W2016719248C126322002 @default.
• W2016719248 hasConceptScore W2016719248C164705383 @default.
• W2016719248 hasConceptScore W2016719248C2777910003 @default.
• W2016719248 hasConceptScore W2016719248C2778198053 @default.
• W2016719248 hasConceptScore W2016719248C2778296771 @default.

• next