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- W2016719534 abstract "Photodynamic therapy has emerged as a promising alternative to current cancer treatment. However, conventional photosensitizers have several limitations due to their unsuitable pharmaceutical formulations and lack of selectivity. Our strategy was to exploit the advantages of nanoparticles and the quenching-induced deactivation of the model photosensitizer hypericin to produce activatable drug delivery systems. Efficient fluorescence and activity quenching were achieved by increasing the drug-loading rate of nanoparticles. In vitro assays confirmed the reversibility of hypericin deactivation, as the hypericin fluorescence and photodynamic activity were recovered upon cell internalization." @default.
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- W2016719534 date "2009-07-10" @default.
- W2016719534 modified "2023-10-13" @default.
- W2016719534 title "Quenching-induced deactivation of photosensitizer by nanoencapsulation to improve phototherapy of cancer" @default.
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- W2016719534 doi "https://doi.org/10.1080/10611860903118930" @default.
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