FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016726392> ?p ?o ?g. }

• W2016726392 endingPage "570" @default.
• W2016726392 startingPage "560" @default.
• W2016726392 abstract "In tumor metastasis, multicellular aggregates of tumor cells form and disseminate into the blood or lymph vessels from the tumor mass, following the formation of tumor cell emboli in distant vessels. However, the mechanism by which aggregates form in the tumor mass is unknown. Neutrophils often exist in tumors and are considered to affect tumor development. We observed that neutrophils had the capacity to induce the aggregation of MCF‐7 human breast carcinoma cells adhering to culture substrates. When MCF‐7 cells were cultured with rat inflammatory neutrophils, the soluble fraction of their lysate, and the conditioned medium of neutrophils stimulated with N‐formyl‐Met‐Leu‐Phe plus cytochalasin B, multicellular aggregates formed within 16 h, and tightly aggregated 3‐D spheroids formed when the cultures were prolonged. The spheroid‐inducing reaction was reversible and energy‐dependent. The MCF‐7 cells induced to aggregate by the neutrophil extract showed growth potential, although the growth rate of the cells was slightly reduced. The aggregation was dependent on E‐cadherin, because the spheroids dispersed into isolated cells on incubation with EGTA or anti‐E‐cadherin antibody following pipetting. The aggregation‐inducing activity in neutrophils was completely inhibited by soybean trypsin‐chymotrypsin inhibitor. Moreover, the commercially available human neutrophil elastase and cathepsin G induced the aggregation of MCF‐7 cells and formation of spheroids. The proteases secreted by infiltrated neutrophils in tumors are implicated in the dissemination of tumor aggregates from primary tumor sites. ( Cancer Sci 2005; 96: 560 –570)" @default.
• W2016726392 created "2016-06-24" @default.
• W2016726392 creator A5016040529 @default.
• W2016726392 creator A5075805401 @default.
• W2016726392 creator A5076538361 @default.
• W2016726392 creator A5080238193 @default.
• W2016726392 creator A5089261680 @default.
• W2016726392 date "2005-08-26" @default.
• W2016726392 modified "2023-10-14" @default.
• W2016726392 title "Induction of multicellular 3-D spheroids of MCF-7 breast carcinoma cells by neutrophil-derived cathepsin G and elastase" @default.
• W2016726392 cites W10381981 @default.
• W2016726392 cites W1234218055 @default.
• W2016726392 cites W1506003867 @default.
• W2016726392 cites W1518549789 @default.
• W2016726392 cites W1535477876 @default.
• W2016726392 cites W1550108534 @default.
• W2016726392 cites W1580655877 @default.
• W2016726392 cites W1908801241 @default.
• W2016726392 cites W1963681491 @default.
• W2016726392 cites W1973424052 @default.
• W2016726392 cites W1977145303 @default.
• W2016726392 cites W1979182118 @default.
• W2016726392 cites W1984483611 @default.
• W2016726392 cites W1985260860 @default.
• W2016726392 cites W1995589202 @default.
• W2016726392 cites W1996270406 @default.
• W2016726392 cites W1999903411 @default.
• W2016726392 cites W2010414816 @default.
• W2016726392 cites W2013109381 @default.
• W2016726392 cites W2026262319 @default.
• W2016726392 cites W2042935646 @default.
• W2016726392 cites W2047039315 @default.
• W2016726392 cites W2050703197 @default.
• W2016726392 cites W2051027197 @default.
• W2016726392 cites W2053716029 @default.
• W2016726392 cites W2054053976 @default.
• W2016726392 cites W206141176 @default.
• W2016726392 cites W2065065140 @default.
• W2016726392 cites W2082344537 @default.
• W2016726392 cites W2082850153 @default.
• W2016726392 cites W2111072594 @default.
• W2016726392 cites W2116554142 @default.
• W2016726392 cites W2131900085 @default.
• W2016726392 cites W2133444342 @default.
• W2016726392 cites W2134290600 @default.
• W2016726392 cites W27714575 @default.
• W2016726392 cites W4242838352 @default.
• W2016726392 doi "https://doi.org/10.1111/j.1349-7006.2005.00097.x" @default.
• W2016726392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16128741" @default.
• W2016726392 hasPublicationYear "2005" @default.
• W2016726392 type Work @default.
• W2016726392 sameAs 2016726392 @default.
• W2016726392 citedByCount "30" @default.
• W2016726392 countsByYear W20167263922012 @default.
• W2016726392 countsByYear W20167263922014 @default.
• W2016726392 countsByYear W20167263922015 @default.
• W2016726392 countsByYear W20167263922016 @default.
• W2016726392 countsByYear W20167263922017 @default.
• W2016726392 countsByYear W20167263922018 @default.
• W2016726392 countsByYear W20167263922019 @default.
• W2016726392 countsByYear W20167263922020 @default.
• W2016726392 countsByYear W20167263922021 @default.
• W2016726392 countsByYear W20167263922022 @default.
• W2016726392 crossrefType "journal-article" @default.
• W2016726392 hasAuthorship W2016726392A5016040529 @default.
• W2016726392 hasAuthorship W2016726392A5075805401 @default.
• W2016726392 hasAuthorship W2016726392A5076538361 @default.
• W2016726392 hasAuthorship W2016726392A5080238193 @default.
• W2016726392 hasAuthorship W2016726392A5089261680 @default.
• W2016726392 hasConcept C121608353 @default.
• W2016726392 hasConcept C175369904 @default.
• W2016726392 hasConcept C181199279 @default.
• W2016726392 hasConcept C185592680 @default.
• W2016726392 hasConcept C202751555 @default.
• W2016726392 hasConcept C2777132095 @default.
• W2016726392 hasConcept C2778050619 @default.
• W2016726392 hasConcept C2779012151 @default.
• W2016726392 hasConcept C2781044401 @default.
• W2016726392 hasConcept C502942594 @default.
• W2016726392 hasConcept C54355233 @default.
• W2016726392 hasConcept C55493867 @default.
• W2016726392 hasConcept C86803240 @default.
• W2016726392 hasConcept C96232424 @default.
• W2016726392 hasConceptScore W2016726392C121608353 @default.
• W2016726392 hasConceptScore W2016726392C175369904 @default.
• W2016726392 hasConceptScore W2016726392C181199279 @default.
• W2016726392 hasConceptScore W2016726392C185592680 @default.
• W2016726392 hasConceptScore W2016726392C202751555 @default.
• W2016726392 hasConceptScore W2016726392C2777132095 @default.
• W2016726392 hasConceptScore W2016726392C2778050619 @default.
• W2016726392 hasConceptScore W2016726392C2779012151 @default.
• W2016726392 hasConceptScore W2016726392C2781044401 @default.
• W2016726392 hasConceptScore W2016726392C502942594 @default.
• W2016726392 hasConceptScore W2016726392C54355233 @default.
• W2016726392 hasConceptScore W2016726392C55493867 @default.
• W2016726392 hasConceptScore W2016726392C86803240 @default.
• W2016726392 hasConceptScore W2016726392C96232424 @default.
• W2016726392 hasIssue "9" @default.

• next