FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016727102> ?p ?o ?g. }

• W2016727102 endingPage "1240" @default.
• W2016727102 startingPage "1227" @default.
• W2016727102 abstract "Liver is a major organ for heme detoxification under disease conditions, but its self-protective mechanisms against the toxicity are unknown. This study aimed to examine roles of carbon monoxide (CO), the gaseous product of heme oxygenase (HO), in ameliorating hepatobiliary dysfunction during catabolism of heme molecules in endotoxemic livers.Vascular resistance and biliary flux of bilirubin-IXalpha, an index of HO-derived CO generation, were monitored in perfused livers of endotoxemic rats. Livers were perfused with HbO(2), which captures nitric oxide (NO) and CO, or metHb, a reagent trapping NO but not CO.In endotoxin-pretreated livers where inducible NO synthase and HO-1 overproduced NO and CO, HbO(2) caused marked vasoconstriction and cholestasis. These changes were not reproduced by the NO synthase inhibitor aminoguanidine alone, but by coadministration of zinc protoporphyrin-IX, an HO inhibitor. CO supplementation attenuated the events caused by aminoguanidine plus zinc protoporphyrin-IX, suggesting that simultaneous elimination of these vasorelaxing gases accounts for a mechanism for HbO(2)-induced changes. This concept was supported by observation that metHb did not cause any cholestasis; the reagent captures NO but triggers CO overproduction through rapid degradation of the heme by HO-1.These results suggest protective roles of CO against hepatobiliary dysfunction caused by heme overloading under stress conditions." @default.
• W2016727102 created "2016-06-24" @default.
• W2016727102 creator A5028484085 @default.
• W2016727102 creator A5032463163 @default.
• W2016727102 creator A5037131620 @default.
• W2016727102 creator A5038654766 @default.
• W2016727102 creator A5055923444 @default.
• W2016727102 creator A5065552630 @default.
• W2016727102 creator A5084473935 @default.
• W2016727102 creator A5087655181 @default.
• W2016727102 creator A5088703013 @default.
• W2016727102 creator A5088880261 @default.
• W2016727102 date "2001-04-01" @default.
• W2016727102 modified "2023-09-30" @default.
• W2016727102 title "Carbon monoxide from heme catabolism protects against hepatobiliary dysfunction in endotoxin-treated rat liver" @default.
• W2016727102 cites W127034668 @default.
• W2016727102 cites W1494977501 @default.
• W2016727102 cites W1517967760 @default.
• W2016727102 cites W1973081785 @default.
• W2016727102 cites W1979421433 @default.
• W2016727102 cites W1989445100 @default.
• W2016727102 cites W1989578024 @default.
• W2016727102 cites W2000094822 @default.
• W2016727102 cites W2004491334 @default.
• W2016727102 cites W2025410711 @default.
• W2016727102 cites W2040223458 @default.
• W2016727102 cites W2044196027 @default.
• W2016727102 cites W2049555023 @default.
• W2016727102 cites W2067011965 @default.
• W2016727102 cites W2067714284 @default.
• W2016727102 cites W2073462501 @default.
• W2016727102 cites W2077026345 @default.
• W2016727102 cites W2078839634 @default.
• W2016727102 cites W2085107543 @default.
• W2016727102 cites W2088689939 @default.
• W2016727102 cites W2097031263 @default.
• W2016727102 cites W2111141380 @default.
• W2016727102 cites W2120505405 @default.
• W2016727102 cites W2124433916 @default.
• W2016727102 cites W2125203526 @default.
• W2016727102 cites W2135613921 @default.
• W2016727102 cites W2148156463 @default.
• W2016727102 cites W2167061215 @default.
• W2016727102 cites W2283620215 @default.
• W2016727102 cites W2286944278 @default.
• W2016727102 cites W2301021332 @default.
• W2016727102 cites W2343171406 @default.
• W2016727102 cites W54118844 @default.
• W2016727102 doi "https://doi.org/10.1053/gast.2001.23249" @default.
• W2016727102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11266386" @default.
• W2016727102 hasPublicationYear "2001" @default.
• W2016727102 type Work @default.
• W2016727102 sameAs 2016727102 @default.
• W2016727102 citedByCount "152" @default.
• W2016727102 countsByYear W20167271022012 @default.
• W2016727102 countsByYear W20167271022013 @default.
• W2016727102 countsByYear W20167271022014 @default.
• W2016727102 countsByYear W20167271022015 @default.
• W2016727102 countsByYear W20167271022016 @default.
• W2016727102 countsByYear W20167271022017 @default.
• W2016727102 countsByYear W20167271022018 @default.
• W2016727102 countsByYear W20167271022019 @default.
• W2016727102 countsByYear W20167271022020 @default.
• W2016727102 countsByYear W20167271022021 @default.
• W2016727102 countsByYear W20167271022022 @default.
• W2016727102 countsByYear W20167271022023 @default.
• W2016727102 crossrefType "journal-article" @default.
• W2016727102 hasAuthorship W2016727102A5028484085 @default.
• W2016727102 hasAuthorship W2016727102A5032463163 @default.
• W2016727102 hasAuthorship W2016727102A5037131620 @default.
• W2016727102 hasAuthorship W2016727102A5038654766 @default.
• W2016727102 hasAuthorship W2016727102A5055923444 @default.
• W2016727102 hasAuthorship W2016727102A5065552630 @default.
• W2016727102 hasAuthorship W2016727102A5084473935 @default.
• W2016727102 hasAuthorship W2016727102A5087655181 @default.
• W2016727102 hasAuthorship W2016727102A5088703013 @default.
• W2016727102 hasAuthorship W2016727102A5088880261 @default.
• W2016727102 hasConcept C126322002 @default.
• W2016727102 hasConcept C134018914 @default.
• W2016727102 hasConcept C161790260 @default.
• W2016727102 hasConcept C178790620 @default.
• W2016727102 hasConcept C181199279 @default.
• W2016727102 hasConcept C185592680 @default.
• W2016727102 hasConcept C2776217839 @default.
• W2016727102 hasConcept C2777513400 @default.
• W2016727102 hasConcept C2777622882 @default.
• W2016727102 hasConcept C2778593092 @default.
• W2016727102 hasConcept C2779219270 @default.
• W2016727102 hasConcept C2781447869 @default.
• W2016727102 hasConcept C29730261 @default.
• W2016727102 hasConcept C512735826 @default.
• W2016727102 hasConcept C519581460 @default.
• W2016727102 hasConcept C55493867 @default.
• W2016727102 hasConcept C62231903 @default.
• W2016727102 hasConcept C71924100 @default.
• W2016727102 hasConcept C96942376 @default.
• W2016727102 hasConcept C98274493 @default.
• W2016727102 hasConceptScore W2016727102C126322002 @default.

• next