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- W2016741674 abstract "Clofibrate, an antilipidemic drug that acts by a still obscure mechanism, is known to specifically increase up to 30-fold the activity of the hepatic cytochrome P-450 isozyme that omega-hydroxlates lauric acid. The thesis that accelerated catabolism of medium-length fatty acids initiated by omega-hydroxylation contributes significantly to the antilipidemic action of clofibrate has been examined by measuring the impact on serum triglyceride levels of coadministering clofibrate and a suicide substrate that inactivates the hydroxylase. The results suggest that the antilipidemic action of clofibrate does not depend critically on the enhanced omega-hydroxylation of fatty acids." @default.
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- W2016741674 date "1986-04-01" @default.
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- W2016741674 title "Dissociation of increased lauric acid ω-hydroxylase activity from the antilipidemic action of clofibrate" @default.
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- W2016741674 doi "https://doi.org/10.1016/0006-2952(86)90264-9" @default.
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