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- W2016741849 abstract "Mildly oxidized low density lipoprotein (mLDL) acutely increases the permeability of the vascular endothelium to molecules that would not otherwise cross the barrier. This study has shown that ascorbic acid tightens the permeability barrier in the endothelial barrier in cells, so this work tested whether it might prevent the increase in endothelial permeability due to mLDL. Treatment of EA.hy926 endothelial cells with mLDL decreased intracellular GSH and activated the cells to further oxidize the mLDL. mLDL also increased endothelial permeability over 2 h to both inulin and ascorbate in cells cultured on semi-permeable filters. This effect was blocked by microtubule and microfilament inhibitors, but not by chelation of intracellular calcium. Intracellular ascorbate both prevented and reversed the mLDL-induced increase in endothelial permeability, an effect mimicked by other cell-penetrant antioxidants. These results suggest a role for endothelial cell ascorbate in ameliorating an important facet of endothelial dysfunction caused by mLDL." @default.
- W2016741849 created "2016-06-24" @default.
- W2016741849 creator A5020150184 @default.
- W2016741849 creator A5054170867 @default.
- W2016741849 date "2010-09-06" @default.
- W2016741849 modified "2023-09-23" @default.
- W2016741849 title "Ascorbic acid prevents increased endothelial permeability caused by oxidized low density lipoprotein" @default.
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- W2016741849 doi "https://doi.org/10.3109/10715762.2010.508496" @default.
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