FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016751172> ?p ?o ?g. }

• W2016751172 endingPage "918" @default.
• W2016751172 startingPage "910" @default.
• W2016751172 abstract "New adjuvants and delivery strategies are needed to optimize the ability of protein-based vaccines to elicit CD8+ T cell responses. We have developed a model vaccine formulation containing ovalbumin (OVA) and the double-stranded RNA analog poly(inosinic acid)–poly(cytidylic acid) (poly(I:C)), a TLR3 agonist. OVA and poly(I:C) were each ion-paired to cetyltrimethylammonium bromide (CTAB) to produce hydrophobic complexes, which were co-encapsulated in pH-sensitive polyketal (PK3) microparticles (1–3 μm) using a single emulsion method. Loading levels ranged from 13.6 to 18.8 μg/mg OVA and 4.8 to 10.3 μg/mg poly(I:C). Murine splenic dendritic cells (DCs) pulsed with PK3-OVA–poly(I:C) microparticles, at antigen doses of 0.01 and 0.1 μg/mL, induced a higher percentage of IFNγ-producing CD8+ T cells than DCs treated with PK3-OVA particles or soluble OVA/poly(I:C). A higher antigen dose (1 μg/mL) was less effective, which can be attributed to CTAB toxicity. At the lowest antigen dose (0.01 μg/mL), PK3-OVA–poly(I:C) microparticles also enhanced TNF-α and IL-2 production in CD8+ T cells. These data demonstrate the potential of polyketal microparticles in formulating effective CD8+ T cell-inducing vaccines comprising protein antigens and dsRNA adjuvants." @default.
• W2016751172 created "2016-06-24" @default.
• W2016751172 creator A5038753777 @default.
• W2016751172 creator A5040233452 @default.
• W2016751172 creator A5068011451 @default.
• W2016751172 creator A5084087276 @default.
• W2016751172 creator A5086673202 @default.
• W2016751172 date "2009-02-01" @default.
• W2016751172 modified "2023-10-16" @default.
• W2016751172 title "The stimulation of CD8+ T cells by dendritic cells pulsed with polyketal microparticles containing ion-paired protein antigen and poly(inosinic acid)–poly(cytidylic acid)" @default.
• W2016751172 cites W1506811134 @default.
• W2016751172 cites W1534324490 @default.
• W2016751172 cites W1580991720 @default.
• W2016751172 cites W1635217668 @default.
• W2016751172 cites W1679259039 @default.
• W2016751172 cites W1959677146 @default.
• W2016751172 cites W1970861673 @default.
• W2016751172 cites W1974433492 @default.
• W2016751172 cites W1974629753 @default.
• W2016751172 cites W1985201557 @default.
• W2016751172 cites W1985786449 @default.
• W2016751172 cites W1988287386 @default.
• W2016751172 cites W1992262718 @default.
• W2016751172 cites W1999355402 @default.
• W2016751172 cites W2000952771 @default.
• W2016751172 cites W2000993433 @default.
• W2016751172 cites W2001982737 @default.
• W2016751172 cites W2022890571 @default.
• W2016751172 cites W2023347211 @default.
• W2016751172 cites W2026018608 @default.
• W2016751172 cites W2029101622 @default.
• W2016751172 cites W2029473550 @default.
• W2016751172 cites W2036594163 @default.
• W2016751172 cites W2044032615 @default.
• W2016751172 cites W2051822492 @default.
• W2016751172 cites W2057521997 @default.
• W2016751172 cites W2062350041 @default.
• W2016751172 cites W2068598861 @default.
• W2016751172 cites W2074871929 @default.
• W2016751172 cites W2076361525 @default.
• W2016751172 cites W2076701673 @default.
• W2016751172 cites W2079752861 @default.
• W2016751172 cites W2082132387 @default.
• W2016751172 cites W2087685632 @default.
• W2016751172 cites W2090640877 @default.
• W2016751172 cites W2091151874 @default.
• W2016751172 cites W2093962452 @default.
• W2016751172 cites W2102403063 @default.
• W2016751172 cites W2104904748 @default.
• W2016751172 cites W2116014851 @default.
• W2016751172 cites W2135674359 @default.
• W2016751172 cites W2137773986 @default.
• W2016751172 cites W2140489687 @default.
• W2016751172 cites W2148817537 @default.
• W2016751172 cites W2160739580 @default.
• W2016751172 cites W2172168743 @default.
• W2016751172 cites W73591399 @default.
• W2016751172 doi "https://doi.org/10.1016/j.biomaterials.2008.10.034" @default.
• W2016751172 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3736733" @default.
• W2016751172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19036430" @default.
• W2016751172 hasPublicationYear "2009" @default.
• W2016751172 type Work @default.
• W2016751172 sameAs 2016751172 @default.
• W2016751172 citedByCount "69" @default.
• W2016751172 countsByYear W20167511722012 @default.
• W2016751172 countsByYear W20167511722013 @default.
• W2016751172 countsByYear W20167511722014 @default.
• W2016751172 countsByYear W20167511722015 @default.
• W2016751172 countsByYear W20167511722016 @default.
• W2016751172 countsByYear W20167511722017 @default.
• W2016751172 countsByYear W20167511722018 @default.
• W2016751172 countsByYear W20167511722019 @default.
• W2016751172 countsByYear W20167511722020 @default.
• W2016751172 countsByYear W20167511722021 @default.
• W2016751172 countsByYear W20167511722022 @default.
• W2016751172 countsByYear W20167511722023 @default.
• W2016751172 crossrefType "journal-article" @default.
• W2016751172 hasAuthorship W2016751172A5038753777 @default.
• W2016751172 hasAuthorship W2016751172A5040233452 @default.
• W2016751172 hasAuthorship W2016751172A5068011451 @default.
• W2016751172 hasAuthorship W2016751172A5084087276 @default.
• W2016751172 hasAuthorship W2016751172A5086673202 @default.
• W2016751172 hasBestOaLocation W20167511722 @default.
• W2016751172 hasConcept C136449434 @default.
• W2016751172 hasConcept C147483822 @default.
• W2016751172 hasConcept C153911025 @default.
• W2016751172 hasConcept C154317977 @default.
• W2016751172 hasConcept C167672396 @default.
• W2016751172 hasConcept C170493617 @default.
• W2016751172 hasConcept C185592680 @default.
• W2016751172 hasConcept C192562407 @default.
• W2016751172 hasConcept C202751555 @default.
• W2016751172 hasConcept C203014093 @default.
• W2016751172 hasConcept C2776709828 @default.
• W2016751172 hasConcept C2776946954 @default.
• W2016751172 hasConcept C2778420691 @default.
• W2016751172 hasConcept C55493867 @default.
• W2016751172 hasConcept C86803240 @default.

• next