FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016751245> ?p ?o ?g. }

• W2016751245 endingPage "88" @default.
• W2016751245 startingPage "82" @default.
• W2016751245 abstract "Objectives. The purpose of the current study was to characterize the role of PTEN in malignant transformation and to evaluate the significance of mutated PTEN exons as prognostic markers in the carcinogenesis of endometrial hyperplasia. A comparison of PTEN mutations as prognostic markers with former investigated prognosticators was also intended. Methods. Histological material from 68 patients with endometrial hyperplasia and 10–20 years of follow-up of whom 18 later developed cancer was examined. PCR amplification and DNA sequencing were performed, screening the most frequently mutated exons 5a–8b of the PTEN gene. Results. Mutations were demonstrated in 13.2% of the patients. Of the patients with cancer development, five showed to have PTEN mutations corresponding to 28%. Of the patients remaining without carcinoma, only 8% had PTEN mutations (P = 0.04). In total, there were three missense, three nonsense, and four frameshift mutations, and twice as many mutations leading to a truncated protein (six) than mutations altering one amino acid in the entire protein (three). Mutations were distributed in the following manner: three in exon 5a, two in exon 5b, two in exon 6, two in exon 7, and one in exon 8b. Only mutations in exons 6, 7, and 8a were connected with cancer development or coexisting cancer and six out of seven mutations within these exons were frameshift or nonsense mutations. Conclusions. Our results showed that mutations in the PTEN gene were statistically more frequent in cases with cancer development or coexisting cancer. Although the specificity was acceptable, the sensitivity of PTEN mutations was too low to make it suitable as a tumor marker (sensitivity of 27% and specificity of 91%) in clinical practice." @default.
• W2016751245 created "2016-06-24" @default.
• W2016751245 creator A5004978590 @default.
• W2016751245 creator A5019614919 @default.
• W2016751245 creator A5021628634 @default.
• W2016751245 creator A5052487974 @default.
• W2016751245 creator A5052895939 @default.
• W2016751245 date "2004-10-01" @default.
• W2016751245 modified "2023-09-26" @default.
• W2016751245 title "Genetic derangements in the tumor suppressor gene PTEN in endometrial precancers as prognostic markers for cancer development: a population-based study from northern Norway with long-term follow-up" @default.
• W2016751245 cites W1939083266 @default.
• W2016751245 cites W1965769128 @default.
• W2016751245 cites W1966686742 @default.
• W2016751245 cites W1971104020 @default.
• W2016751245 cites W1973577899 @default.
• W2016751245 cites W1996130791 @default.
• W2016751245 cites W1996399533 @default.
• W2016751245 cites W2007838802 @default.
• W2016751245 cites W2014514949 @default.
• W2016751245 cites W2058298696 @default.
• W2016751245 cites W2074696167 @default.
• W2016751245 cites W2090925814 @default.
• W2016751245 cites W2097113048 @default.
• W2016751245 cites W2113190292 @default.
• W2016751245 cites W2117576588 @default.
• W2016751245 cites W2122522737 @default.
• W2016751245 cites W2126111731 @default.
• W2016751245 cites W2154136908 @default.
• W2016751245 cites W2161810908 @default.
• W2016751245 cites W2162301116 @default.
• W2016751245 cites W2261888961 @default.
• W2016751245 doi "https://doi.org/10.1016/j.ygyno.2004.07.024" @default.
• W2016751245 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15385114" @default.
• W2016751245 hasPublicationYear "2004" @default.
• W2016751245 type Work @default.
• W2016751245 sameAs 2016751245 @default.
• W2016751245 citedByCount "13" @default.
• W2016751245 countsByYear W20167512452012 @default.
• W2016751245 countsByYear W20167512452014 @default.
• W2016751245 countsByYear W20167512452015 @default.
• W2016751245 countsByYear W20167512452019 @default.
• W2016751245 countsByYear W20167512452021 @default.
• W2016751245 crossrefType "journal-article" @default.
• W2016751245 hasAuthorship W2016751245A5004978590 @default.
• W2016751245 hasAuthorship W2016751245A5019614919 @default.
• W2016751245 hasAuthorship W2016751245A5021628634 @default.
• W2016751245 hasAuthorship W2016751245A5052487974 @default.
• W2016751245 hasAuthorship W2016751245A5052895939 @default.
• W2016751245 hasConcept C104317684 @default.
• W2016751245 hasConcept C121608353 @default.
• W2016751245 hasConcept C190283241 @default.
• W2016751245 hasConcept C2777609662 @default.
• W2016751245 hasConcept C2778264664 @default.
• W2016751245 hasConcept C29906990 @default.
• W2016751245 hasConcept C36823959 @default.
• W2016751245 hasConcept C501734568 @default.
• W2016751245 hasConcept C502942594 @default.
• W2016751245 hasConcept C54355233 @default.
• W2016751245 hasConcept C555283112 @default.
• W2016751245 hasConcept C71924100 @default.
• W2016751245 hasConcept C75563809 @default.
• W2016751245 hasConcept C86554907 @default.
• W2016751245 hasConcept C86803240 @default.
• W2016751245 hasConcept C96777560 @default.
• W2016751245 hasConceptScore W2016751245C104317684 @default.
• W2016751245 hasConceptScore W2016751245C121608353 @default.
• W2016751245 hasConceptScore W2016751245C190283241 @default.
• W2016751245 hasConceptScore W2016751245C2777609662 @default.
• W2016751245 hasConceptScore W2016751245C2778264664 @default.
• W2016751245 hasConceptScore W2016751245C29906990 @default.
• W2016751245 hasConceptScore W2016751245C36823959 @default.
• W2016751245 hasConceptScore W2016751245C501734568 @default.
• W2016751245 hasConceptScore W2016751245C502942594 @default.
• W2016751245 hasConceptScore W2016751245C54355233 @default.
• W2016751245 hasConceptScore W2016751245C555283112 @default.
• W2016751245 hasConceptScore W2016751245C71924100 @default.
• W2016751245 hasConceptScore W2016751245C75563809 @default.
• W2016751245 hasConceptScore W2016751245C86554907 @default.
• W2016751245 hasConceptScore W2016751245C86803240 @default.
• W2016751245 hasConceptScore W2016751245C96777560 @default.
• W2016751245 hasIssue "1" @default.
• W2016751245 hasLocation W20167512451 @default.
• W2016751245 hasLocation W20167512452 @default.
• W2016751245 hasOpenAccess W2016751245 @default.
• W2016751245 hasPrimaryLocation W20167512451 @default.
• W2016751245 hasRelatedWork W1540914548 @default.
• W2016751245 hasRelatedWork W179064230 @default.
• W2016751245 hasRelatedWork W1982070672 @default.
• W2016751245 hasRelatedWork W2016751245 @default.
• W2016751245 hasRelatedWork W2081165832 @default.
• W2016751245 hasRelatedWork W2470625088 @default.
• W2016751245 hasRelatedWork W2594801 @default.
• W2016751245 hasRelatedWork W2885196233 @default.
• W2016751245 hasRelatedWork W306848151 @default.
• W2016751245 hasRelatedWork W4235910810 @default.
• W2016751245 hasVolume "95" @default.
• W2016751245 isParatext "false" @default.
• W2016751245 isRetracted "false" @default.

• next