FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016751415> ?p ?o ?g. }

• W2016751415 endingPage "751" @default.
• W2016751415 startingPage "747" @default.
• W2016751415 abstract "The study of specific target protein expression is often performed by western blotting, a commonly used method to measure the protein expression in neuroscience research by specific antibodies. Housekeeping proteins are used as an internal control for protein loading as well as reference in the western blotting analysis. This practice is based on the belief that such housekeeping genes are considered to be ubiquitously and constitutively expressed in every tissue and produce the minimal essential transcripts necessary for normal cellular function. The most commonly used housekeeping proteins are β-actin, β-tubulin, and glyceraldehyde 3-phosphate dehydrogenase (GAPDH). However, recent studies have shown significant variation in some housekeeping genes both at the mRNA and protein levels in various neuropathological events, such as spinal cord injury and Alzheimer's diseases. Changes of housekeeping genes are also induced by non-neuronal diseases in various tissues. Therefore, these discoveries raise a potential concern regarding whether using a housekeeping protein as an internal standard for target protein analysis is an appropriate practice. This minireview will focus on (I) the effects of neuronal and non-neuronal diseases, experimental condition, and tissue-specific roles on alteration of housekeeping genes, and (II) alternative internal standards for gene and protein expression analysis." @default.
• W2016751415 created "2016-06-24" @default.
• W2016751415 creator A5000125292 @default.
• W2016751415 creator A5075407753 @default.
• W2016751415 date "2013-04-01" @default.
• W2016751415 modified "2023-10-17" @default.
• W2016751415 title "An old method facing a new challenge: Re-visiting housekeeping proteins as internal reference control for neuroscience research" @default.
• W2016751415 cites W1506451409 @default.
• W2016751415 cites W1584154254 @default.
• W2016751415 cites W1935777006 @default.
• W2016751415 cites W196365189 @default.
• W2016751415 cites W1974907177 @default.
• W2016751415 cites W1978513255 @default.
• W2016751415 cites W1993988048 @default.
• W2016751415 cites W2004873595 @default.
• W2016751415 cites W2026399234 @default.
• W2016751415 cites W2035963479 @default.
• W2016751415 cites W2037034010 @default.
• W2016751415 cites W2051931197 @default.
• W2016751415 cites W2052163433 @default.
• W2016751415 cites W2058039595 @default.
• W2016751415 cites W2064391449 @default.
• W2016751415 cites W2071327579 @default.
• W2016751415 cites W2071561569 @default.
• W2016751415 cites W2073101403 @default.
• W2016751415 cites W2073371406 @default.
• W2016751415 cites W2079516818 @default.
• W2016751415 cites W2081680109 @default.
• W2016751415 cites W2082351437 @default.
• W2016751415 cites W2088140830 @default.
• W2016751415 cites W2088469860 @default.
• W2016751415 cites W2089644592 @default.
• W2016751415 cites W2089646276 @default.
• W2016751415 cites W2119151452 @default.
• W2016751415 cites W2128268768 @default.
• W2016751415 cites W2131247441 @default.
• W2016751415 cites W2143900628 @default.
• W2016751415 cites W2161955670 @default.
• W2016751415 cites W2161968177 @default.
• W2016751415 doi "https://doi.org/10.1016/j.lfs.2013.02.014" @default.
• W2016751415 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3614345" @default.
• W2016751415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23454168" @default.
• W2016751415 hasPublicationYear "2013" @default.
• W2016751415 type Work @default.
• W2016751415 sameAs 2016751415 @default.
• W2016751415 citedByCount "130" @default.
• W2016751415 countsByYear W20167514152013 @default.
• W2016751415 countsByYear W20167514152014 @default.
• W2016751415 countsByYear W20167514152015 @default.
• W2016751415 countsByYear W20167514152016 @default.
• W2016751415 countsByYear W20167514152017 @default.
• W2016751415 countsByYear W20167514152018 @default.
• W2016751415 countsByYear W20167514152019 @default.
• W2016751415 countsByYear W20167514152020 @default.
• W2016751415 countsByYear W20167514152021 @default.
• W2016751415 countsByYear W20167514152022 @default.
• W2016751415 countsByYear W20167514152023 @default.
• W2016751415 crossrefType "journal-article" @default.
• W2016751415 hasAuthorship W2016751415A5000125292 @default.
• W2016751415 hasAuthorship W2016751415A5075407753 @default.
• W2016751415 hasBestOaLocation W20167514152 @default.
• W2016751415 hasConcept C104317684 @default.
• W2016751415 hasConcept C134792803 @default.
• W2016751415 hasConcept C150194340 @default.
• W2016751415 hasConcept C153911025 @default.
• W2016751415 hasConcept C33922130 @default.
• W2016751415 hasConcept C54355233 @default.
• W2016751415 hasConcept C70721500 @default.
• W2016751415 hasConcept C85265743 @default.
• W2016751415 hasConcept C86803240 @default.
• W2016751415 hasConcept C90861158 @default.
• W2016751415 hasConcept C95444343 @default.
• W2016751415 hasConceptScore W2016751415C104317684 @default.
• W2016751415 hasConceptScore W2016751415C134792803 @default.
• W2016751415 hasConceptScore W2016751415C150194340 @default.
• W2016751415 hasConceptScore W2016751415C153911025 @default.
• W2016751415 hasConceptScore W2016751415C33922130 @default.
• W2016751415 hasConceptScore W2016751415C54355233 @default.
• W2016751415 hasConceptScore W2016751415C70721500 @default.
• W2016751415 hasConceptScore W2016751415C85265743 @default.
• W2016751415 hasConceptScore W2016751415C86803240 @default.
• W2016751415 hasConceptScore W2016751415C90861158 @default.
• W2016751415 hasConceptScore W2016751415C95444343 @default.
• W2016751415 hasFunder F4320306219 @default.
• W2016751415 hasFunder F4320306229 @default.
• W2016751415 hasIssue "13" @default.
• W2016751415 hasLocation W20167514151 @default.
• W2016751415 hasLocation W20167514152 @default.
• W2016751415 hasLocation W20167514153 @default.
• W2016751415 hasLocation W20167514154 @default.
• W2016751415 hasOpenAccess W2016751415 @default.
• W2016751415 hasPrimaryLocation W20167514151 @default.
• W2016751415 hasRelatedWork W2016751415 @default.
• W2016751415 hasRelatedWork W2035963479 @default.
• W2016751415 hasRelatedWork W2068308269 @default.
• W2016751415 hasRelatedWork W2088103984 @default.
• W2016751415 hasRelatedWork W2145879504 @default.
• W2016751415 hasRelatedWork W2152544605 @default.

• next