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- W2016751639 abstract "As we have shown previously that protein antigen applied epicutaneously (EC) in mice inhibits TNP‐specific Th1‐mediated contact sensitivity (CS), we postulated that the maneuver of EC immunization might also suppress Tc1‐dependent CS response. Here we showed that EC immunization of normal mice with 2,4‐dinitrophenylated bovine serum albumin (DNP‐BSA) applied on the skin in the form of a patch induces a state of subsequent unresponsiveness due to regulatory T cells (Treg) that inhibited sensitization and elicitation of effector T‐cell responses. Suppression is transferable in vivo by TCRαβ + CD4 + CD25 + lymphocytes harvested from lymph nodes (LNs) of skin‐patched animals. Flow cytometry revealed that EC immunization with DNP‐BSA increased TCRαβ + CD4 + CD25 + FoxP3 + lymphocytes in subcutaneous LNs, suggesting that observed suppression was mediated by Treg cells. Further, in vitro experiments showed that EC immunization with DNP‐BSA prior to 1‐fluoro‐2,4‐dinitrobenzen sensitization suppressed LN cell proliferation and inhibited production of TNF‐α, IL‐12 and IFN‐γ. Using a transwell system or anti‐CTLA‐4 mAb, we found that EC induced suppression required direct Treg–effector cell contact and is CTLA‐4‐dependent." @default.
- W2016751639 created "2016-06-24" @default.
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- W2016751639 date "2012-01-31" @default.
- W2016751639 modified "2023-10-15" @default.
- W2016751639 title "Epicutaneous immunization with DNP‐BSA induces CD4 + CD25 + Treg cells that inhibit Tc1‐mediated CS" @default.
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- W2016751639 doi "https://doi.org/10.1038/icb.2012.1" @default.
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