Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016752908> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2016752908 endingPage "4970" @default.
- W2016752908 startingPage "4964" @default.
- W2016752908 abstract "Synaptobrevin is a membrane-spanning soluble N-ethyl maleimid-sensitive factor (NSF) attachment protein receptor (SNARE) protein of synaptic vesicles that is essential for neurotransmitter release. Various lines of evidence indicate that it exists alternatively as a monomer, as a homodimer, as a heterodimer with synaptophysin, or as a ternary complex with other SNAREs at the various stages of the synaptic vesicle cycle. Homodimerization of synaptobrevin was previously shown by different authors to depend on its single transmembrane segment, and the crucial residues forming the helix-helix interface have been mapped. Since another recent study challenged these results, we reinvestigated this issue. Here, we show that native synaptobrevin can be cross-linked in synaptic vesicle membranes to a homodimer by disulfide bond formation between cysteine residues of the transmembrane segment. Further, we demonstrate that determination of synaptobrevin transmembrane segment interactions in membranes or in detergent solution requires careful control of experimental conditions. Thus, our present results corroborate that homodimerization of synaptobrevin is mediated by its transmembrane segment." @default.
- W2016752908 created "2016-06-24" @default.
- W2016752908 creator A5028309994 @default.
- W2016752908 creator A5074679165 @default.
- W2016752908 creator A5090147251 @default.
- W2016752908 date "2004-04-07" @default.
- W2016752908 modified "2023-09-25" @default.
- W2016752908 title "Synaptobrevin Transmembrane Domain DimerizationRevisited" @default.
- W2016752908 cites W1484324228 @default.
- W2016752908 cites W1607355583 @default.
- W2016752908 cites W185955435 @default.
- W2016752908 cites W1879668390 @default.
- W2016752908 cites W1963755507 @default.
- W2016752908 cites W1984394526 @default.
- W2016752908 cites W1987927734 @default.
- W2016752908 cites W2015840191 @default.
- W2016752908 cites W2020075607 @default.
- W2016752908 cites W2032433700 @default.
- W2016752908 cites W2035852278 @default.
- W2016752908 cites W2051103934 @default.
- W2016752908 cites W2058555144 @default.
- W2016752908 cites W2076636373 @default.
- W2016752908 cites W2110884380 @default.
- W2016752908 cites W2129060802 @default.
- W2016752908 doi "https://doi.org/10.1021/bi0362875" @default.
- W2016752908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15109254" @default.
- W2016752908 hasPublicationYear "2004" @default.
- W2016752908 type Work @default.
- W2016752908 sameAs 2016752908 @default.
- W2016752908 citedByCount "47" @default.
- W2016752908 countsByYear W20167529082012 @default.
- W2016752908 countsByYear W20167529082013 @default.
- W2016752908 countsByYear W20167529082014 @default.
- W2016752908 countsByYear W20167529082015 @default.
- W2016752908 countsByYear W20167529082016 @default.
- W2016752908 countsByYear W20167529082017 @default.
- W2016752908 countsByYear W20167529082018 @default.
- W2016752908 crossrefType "journal-article" @default.
- W2016752908 hasAuthorship W2016752908A5028309994 @default.
- W2016752908 hasAuthorship W2016752908A5074679165 @default.
- W2016752908 hasAuthorship W2016752908A5090147251 @default.
- W2016752908 hasConcept C118892022 @default.
- W2016752908 hasConcept C12554922 @default.
- W2016752908 hasConcept C130316041 @default.
- W2016752908 hasConcept C134499376 @default.
- W2016752908 hasConcept C148785051 @default.
- W2016752908 hasConcept C170493617 @default.
- W2016752908 hasConcept C185592680 @default.
- W2016752908 hasConcept C24530287 @default.
- W2016752908 hasConcept C2777029164 @default.
- W2016752908 hasConcept C2908790754 @default.
- W2016752908 hasConcept C41625074 @default.
- W2016752908 hasConcept C55493867 @default.
- W2016752908 hasConcept C86803240 @default.
- W2016752908 hasConceptScore W2016752908C118892022 @default.
- W2016752908 hasConceptScore W2016752908C12554922 @default.
- W2016752908 hasConceptScore W2016752908C130316041 @default.
- W2016752908 hasConceptScore W2016752908C134499376 @default.
- W2016752908 hasConceptScore W2016752908C148785051 @default.
- W2016752908 hasConceptScore W2016752908C170493617 @default.
- W2016752908 hasConceptScore W2016752908C185592680 @default.
- W2016752908 hasConceptScore W2016752908C24530287 @default.
- W2016752908 hasConceptScore W2016752908C2777029164 @default.
- W2016752908 hasConceptScore W2016752908C2908790754 @default.
- W2016752908 hasConceptScore W2016752908C41625074 @default.
- W2016752908 hasConceptScore W2016752908C55493867 @default.
- W2016752908 hasConceptScore W2016752908C86803240 @default.
- W2016752908 hasIssue "17" @default.
- W2016752908 hasLocation W20167529081 @default.
- W2016752908 hasLocation W20167529082 @default.
- W2016752908 hasOpenAccess W2016752908 @default.
- W2016752908 hasPrimaryLocation W20167529081 @default.
- W2016752908 hasRelatedWork W1587126988 @default.
- W2016752908 hasRelatedWork W1967868876 @default.
- W2016752908 hasRelatedWork W2010112989 @default.
- W2016752908 hasRelatedWork W2016752908 @default.
- W2016752908 hasRelatedWork W2044355928 @default.
- W2016752908 hasRelatedWork W2058555144 @default.
- W2016752908 hasRelatedWork W2059160047 @default.
- W2016752908 hasRelatedWork W2902332755 @default.
- W2016752908 hasRelatedWork W3119367020 @default.
- W2016752908 hasRelatedWork W4213361830 @default.
- W2016752908 hasVolume "43" @default.
- W2016752908 isParatext "false" @default.
- W2016752908 isRetracted "false" @default.
- W2016752908 magId "2016752908" @default.
- W2016752908 workType "article" @default.