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• W2016753466 abstract "The influx of genomic sequence information has led to the concept of structural proteomics, the determination of protein structures on a genome-wide scale. Here we describe an approach to structural proteomics of small proteins using NMR spectroscopy. Over 500 small proteins from several organisms were cloned, expressed, purified, and evaluated by NMR. Although there was variability among proteomes, overall 20% of these proteins were found to be readily amenable to NMR structure determination. NMR sample preparation was centralized in one facility, and a distributive approach was used for NMR data collection and analysis. Twelve structures are reported here as part of this approach, which allowed us to infer putative functions for several conserved hypothetical proteins." @default.
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• W2016753466 date "2002-02-19" @default.
• W2016753466 modified "2023-10-18" @default.
• W2016753466 title "An NMR approach to structural proteomics" @default.
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• W2016753466 doi "https://doi.org/10.1073/pnas.042684599" @default.
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