FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016755131> ?p ?o ?g. }

• W2016755131 endingPage "176" @default.
• W2016755131 startingPage "168" @default.
• W2016755131 abstract "Objective: To evaluate the diagnostic efficacy (accuracy, sensitivity, specificity) of 1.0 M gadobutrol versus 0.5 M gadopentetate for the classification of lesions as either benign or malignant in patients with known or suspected liver lesions. Methods and Materials: A multicenter, phase-III, randomized, interindividually controlled comparison study with blinded reader evaluation was performed to investigate the diagnostic efficacy of a bolus injection of 1.0 M gadobutrol compared with 0.5 M gadopentetate at a dose of 0.1 mmol Gd/kg BW. The imaging protocol included a dynamic 3D-evaluation, static conventional, and fat saturated T1-weighted sequences. MR datasets were evaluated by 3 independent radiologists. The standard of reference was defined by an independent truth panel (radiologist or hepatologist). The safety evaluation included adverse events, vital signs, and physical examination. Results: A total of 497 of 572 patients were eligible for the final efficacy analysis. Noninferiority of gadobutrol-enhanced magnetic resonance imaging (MRI) for the classification of liver lesions was demonstrated on the basis of diagnostic accuracy determined by the on-site investigators (−0.098, 0.021) as well as for the average reader of the blinded evaluation (−0.096, 0.014) (95% confidence interval), compared with the predefined standard of reference. Very similar increases in sensitivity (ranging from ∼10% to ∼55%) and specificity (ranging from ∼1%–∼18%) compared with precontrast MRI were also observed for the 2 contrast agent groups, with maximum differences of 4%. Very similar, low rates of adverse events were recorded for each of the 2 groups. No clinically relevant changes in vital signs or the results of the physical examination were observed in any patient. Conclusion: This study documents evidence for the noninferiority of a single i.v. bolus injection of 1.0 M gadobutrol (0.1 mmol/kg body weight) to 0.5 M gadopentetate (0.1 mmol/kg body weight) in the diagnostic assessment of liver lesions with contrast-enhanced MRI. The known excellent safety profile of gadobutrol was confirmed in this clinical trial and is similar to that of gadopentetate." @default.
• W2016755131 created "2016-06-24" @default.
• W2016755131 creator A5003233395 @default.
• W2016755131 creator A5008158491 @default.
• W2016755131 creator A5008921748 @default.
• W2016755131 creator A5013330370 @default.
• W2016755131 creator A5016600218 @default.
• W2016755131 creator A5025318079 @default.
• W2016755131 creator A5027988620 @default.
• W2016755131 creator A5033618526 @default.
• W2016755131 creator A5035318279 @default.
• W2016755131 creator A5035727789 @default.
• W2016755131 creator A5035873897 @default.
• W2016755131 creator A5038326189 @default.
• W2016755131 creator A5047030030 @default.
• W2016755131 creator A5048075038 @default.
• W2016755131 creator A5053831258 @default.
• W2016755131 creator A5053988731 @default.
• W2016755131 creator A5055262652 @default.
• W2016755131 creator A5057463669 @default.
• W2016755131 creator A5059519624 @default.
• W2016755131 creator A5064464829 @default.
• W2016755131 creator A5077780679 @default.
• W2016755131 creator A5081053135 @default.
• W2016755131 creator A5083162350 @default.
• W2016755131 creator A5088444523 @default.
• W2016755131 date "2009-03-01" @default.
• W2016755131 modified "2023-10-13" @default.
• W2016755131 title "Comparison of 1.0 M Gadobutrol and 0.5 M Gadopentetate Dimeglumine-Enhanced Magnetic Resonance Imaging in Five Hundred Seventy-Two Patients With Known or Suspected Liver Lesions" @default.
• W2016755131 cites W1963712830 @default.
• W2016755131 cites W1965033907 @default.
• W2016755131 cites W1966418790 @default.
• W2016755131 cites W1969927333 @default.
• W2016755131 cites W1981805801 @default.
• W2016755131 cites W1999980483 @default.
• W2016755131 cites W2002441805 @default.
• W2016755131 cites W2012390888 @default.
• W2016755131 cites W2020587249 @default.
• W2016755131 cites W2021729554 @default.
• W2016755131 cites W2022646432 @default.
• W2016755131 cites W2023116210 @default.
• W2016755131 cites W2025545140 @default.
• W2016755131 cites W2030003406 @default.
• W2016755131 cites W2032738777 @default.
• W2016755131 cites W2037958633 @default.
• W2016755131 cites W2041285380 @default.
• W2016755131 cites W2047991671 @default.
• W2016755131 cites W2061612871 @default.
• W2016755131 cites W2065965126 @default.
• W2016755131 cites W2072052518 @default.
• W2016755131 cites W2077387095 @default.
• W2016755131 cites W2091148531 @default.
• W2016755131 cites W2105130321 @default.
• W2016755131 cites W2109391927 @default.
• W2016755131 cites W2120899599 @default.
• W2016755131 cites W2128448383 @default.
• W2016755131 cites W2128687762 @default.
• W2016755131 cites W2139954808 @default.
• W2016755131 cites W2150489367 @default.
• W2016755131 cites W2153521951 @default.
• W2016755131 cites W2158322653 @default.
• W2016755131 cites W2162266695 @default.
• W2016755131 cites W2318895935 @default.
• W2016755131 cites W2324490028 @default.
• W2016755131 cites W2333106507 @default.
• W2016755131 cites W2396473834 @default.
• W2016755131 cites W2411076863 @default.
• W2016755131 cites W2430349590 @default.
• W2016755131 cites W3032381247 @default.
• W2016755131 cites W51916057 @default.
• W2016755131 doi "https://doi.org/10.1097/rli.0b013e318198a0ae" @default.
• W2016755131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19169143" @default.
• W2016755131 hasPublicationYear "2009" @default.
• W2016755131 type Work @default.
• W2016755131 sameAs 2016755131 @default.
• W2016755131 citedByCount "36" @default.
• W2016755131 countsByYear W20167551312012 @default.
• W2016755131 countsByYear W20167551312013 @default.
• W2016755131 countsByYear W20167551312014 @default.
• W2016755131 countsByYear W20167551312015 @default.
• W2016755131 countsByYear W20167551312016 @default.
• W2016755131 countsByYear W20167551312017 @default.
• W2016755131 countsByYear W20167551312018 @default.
• W2016755131 countsByYear W20167551312019 @default.
• W2016755131 countsByYear W20167551312021 @default.
• W2016755131 crossrefType "journal-article" @default.
• W2016755131 hasAuthorship W2016755131A5003233395 @default.
• W2016755131 hasAuthorship W2016755131A5008158491 @default.
• W2016755131 hasAuthorship W2016755131A5008921748 @default.
• W2016755131 hasAuthorship W2016755131A5013330370 @default.
• W2016755131 hasAuthorship W2016755131A5016600218 @default.
• W2016755131 hasAuthorship W2016755131A5025318079 @default.
• W2016755131 hasAuthorship W2016755131A5027988620 @default.
• W2016755131 hasAuthorship W2016755131A5033618526 @default.
• W2016755131 hasAuthorship W2016755131A5035318279 @default.
• W2016755131 hasAuthorship W2016755131A5035727789 @default.
• W2016755131 hasAuthorship W2016755131A5035873897 @default.
• W2016755131 hasAuthorship W2016755131A5038326189 @default.

• next